HUP9802897A2 - Optikailag aktív piridil-4H-1,2,4-oxadiazin-származék, annak alkalmazása vaszkuláris betegségek kezelésére, valamint ilyen származékot hatóanyagként tartalmazó gyógyászati készítmény - Google Patents

Optikailag aktív piridil-4H-1,2,4-oxadiazin-származék, annak alkalmazása vaszkuláris betegségek kezelésére, valamint ilyen származékot hatóanyagként tartalmazó gyógyászati készítmény

Info

Publication number
HUP9802897A2
HUP9802897A2 HU9802897A HUP9802897A HUP9802897A2 HU P9802897 A2 HUP9802897 A2 HU P9802897A2 HU 9802897 A HU9802897 A HU 9802897A HU P9802897 A HUP9802897 A HU P9802897A HU P9802897 A2 HUP9802897 A2 HU P9802897A2
Authority
HU
Hungary
Prior art keywords
pyridyl
compound
treatment
vascular diseases
pharmaceutical composition
Prior art date
Application number
HU9802897A
Other languages
English (en)
Inventor
Andrea Jednákovits
László Ürögdi
László Dénes
István Kurucz
Mihály Barabás
Ernő Bácsy
Zsuzsanna Korom
Ede Márványos
Zoltán Nagy
László Ürge
Károly Acsai
Jenő Szilbereky
Zita Csákai
Péter Krajcsi
Magdolna Török
Original Assignee
BIOREX Kutató és Fejlesztő Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOREX Kutató és Fejlesztő Rt. filed Critical BIOREX Kutató és Fejlesztő Rt.
Priority to HU9802897A priority Critical patent/HU226617B1/hu
Publication of HU9802897D0 publication Critical patent/HU9802897D0/hu
Priority to UA2001063850A priority patent/UA70340C2/uk
Priority to PL346767A priority patent/PL196584B1/pl
Priority to PT99961225T priority patent/PT1147105E/pt
Priority to AU17906/00A priority patent/AU765336B2/en
Priority to SK234-2001A priority patent/SK285582B6/sk
Priority to AT99961225T priority patent/ATE266027T1/de
Priority to CZ20011550A priority patent/CZ300764B6/cs
Priority to IL14151599A priority patent/IL141515A/xx
Priority to PCT/HU1999/000095 priority patent/WO2000035914A1/en
Priority to BR9913982-0A priority patent/BR9913982A/pt
Priority to ES99961225T priority patent/ES2219091T3/es
Priority to US09/762,949 priority patent/US6384029B1/en
Priority to DK99961225T priority patent/DK1147105T3/da
Priority to DE69917074T priority patent/DE69917074T2/de
Priority to CA002340734A priority patent/CA2340734C/en
Priority to EP99961225A priority patent/EP1147105B1/en
Priority to JP2000588174A priority patent/JP2002532498A/ja
Priority to RU2001118854/04A priority patent/RU2222538C2/ru
Priority to YUP-250/01A priority patent/RS50129B/sr
Priority to KR1020017002870A priority patent/KR100661774B1/ko
Priority to EEP200100188A priority patent/EE04551B1/xx
Priority to SI9930566T priority patent/SI1147105T1/xx
Publication of HUP9802897A2 publication Critical patent/HUP9802897A2/hu
Priority to ZA200101182A priority patent/ZA200101182B/en
Priority to HR20010133A priority patent/HRP20010133B1/xx
Priority to BG105342A priority patent/BG65179B1/bg
Priority to NO20012310A priority patent/NO317649B1/no
Publication of HUP9802897A3 publication Critical patent/HUP9802897A3/hu
Publication of HU226617B1 publication Critical patent/HU226617B1/hu
Priority to JP2011128516A priority patent/JP5620340B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

A találmány egy piridil-4H-1,2,4-oxadiazin-származék optikailag aktívalakjára, annak gyógyászati alkalmazására és a vegyületethatóanyagként tartalmazó gyógyászati készítményekre vonatkozik. Atalálmány tárgya nevezetesen az 5,6-dihidro-5-[(1-piperidinil)-metil]-3-(3-piridil)-4H-1,2,4-oxadiazin (-)-enantiomerje és annak savaddícióssói,valamint a vegyületek alkalmazása vaszkuláris betegségekkezelésére, továbbá az e vegyületeket hatóanyagként tartalmazógyógyászati készítmények. Ó
HU9802897A 1998-12-14 1998-12-14 Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient HU226617B1 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
HU9802897A HU226617B1 (en) 1998-12-14 1998-12-14 Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient
UA2001063850A UA70340C2 (en) 1998-12-14 1999-07-12 Optically active 5,6-dihydro-5-[(1-piperidinyl)-meoptically active 5,6-dihydro-5-[(1-piperidinyl)-methyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method fthyl-3-(3-pyridyl)-4h-1,2,4-oxadiazine, a method for the treatment and prevention of vascular diseasor the treatment and prevention of vascular diseases and a pharmaceutical composition es and a pharmaceutical composition
SI9930566T SI1147105T1 (en) 1998-12-14 1999-12-07 Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatement of vascular diseases
DE69917074T DE69917074T2 (de) 1998-12-14 1999-12-07 Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten
JP2000588174A JP2002532498A (ja) 1998-12-14 1999-12-07 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用
AU17906/00A AU765336B2 (en) 1998-12-14 1999-12-07 Optically active pyridyl-4H-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases
SK234-2001A SK285582B6 (sk) 1998-12-14 1999-12-07 Opticky aktívny derivát pyridyl-4H-1,2,4-oxadiazínu a jeho použitie na výrobu liečiva na liečenie vaskulárnych ochorení
AT99961225T ATE266027T1 (de) 1998-12-14 1999-12-07 Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten
CZ20011550A CZ300764B6 (cs) 1998-12-14 1999-12-07 Opticky aktivní derivát pyridyl-4H-1,2,4-oxadiazinu, jeho použití pri lécbe vaskulárních onemocnení a farmaceutické kompozice ho obsahující
IL14151599A IL141515A (en) 1998-12-14 1999-12-07 Optically active pyridyl- 4h - 1, 2, 4 - oxadiazine derivative and its use in the treatment of vascular diseases and pharmaceutical composition comprising same
PCT/HU1999/000095 WO2000035914A1 (en) 1998-12-14 1999-12-07 Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases
BR9913982-0A BR9913982A (pt) 1998-12-14 1999-12-07 Derivado de piridil-4h-1,2,4-oxadiazina opticamente ativo e seu uso no tratamento de doenças vasculares
ES99961225T ES2219091T3 (es) 1998-12-14 1999-12-07 Derivado de piridil-4h-1,2,4-oxadiazina optimamente activo y su uso en el tratamiento de las enfermedades vasculares.
US09/762,949 US6384029B1 (en) 1998-12-14 1999-12-07 Optically active pyridyl-4h-1,2,4-oxdadiazine derivative and its use in the treatment of vascular diseases
DK99961225T DK1147105T3 (da) 1998-12-14 1999-12-07 Optisk aktivt pyridyl-4H-1,2,4-oxadiazinderivat og anvendelse af dette til behandling af karsygdomme
PL346767A PL196584B1 (pl) 1998-12-14 1999-12-07 Optycznie czynna pochodna pirydylo-4H-1,2,4-oksadiazyny i jej zastosowanie w leczeniu chorób naczyń
CA002340734A CA2340734C (en) 1998-12-14 1999-12-07 Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases
EP99961225A EP1147105B1 (en) 1998-12-14 1999-12-07 Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatement of vascular diseases
PT99961225T PT1147105E (pt) 1998-12-14 1999-12-07 Derivado de piridil-4h-1,2,4-oxadiazina opticamente activo e sua utilizacao no tratamento de doencas vasculares
RU2001118854/04A RU2222538C2 (ru) 1998-12-14 1999-12-07 Оптически активное производное пиридил-4н-1,2,4-оксадиазина и фармацевтическая композиция
YUP-250/01A RS50129B (sr) 1998-12-14 1999-12-07 Optički aktivan derivat piridil-4h-1,2,4-oksadiazina i njegova upotreba u proizvodnji lekova za tretiranje vaskularnih bolesti
KR1020017002870A KR100661774B1 (ko) 1998-12-14 1999-12-07 광학적 활성 피리딜-4에이치-1,2,4-옥사디아진 유도체 및이것의 혈관 질환의 치료에서의 용도
EEP200100188A EE04551B1 (et) 1998-12-14 1999-12-07 Optiliselt aktiivne pridl-4H-1,2,4-oksadiasiini derivaat ja selle kasutamine vaskulaarsete haiguste ravis
ZA200101182A ZA200101182B (en) 1998-12-14 2001-02-12 Optically active pyridyl-4H-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases.
HR20010133A HRP20010133B1 (en) 1998-12-14 2001-02-23 Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases
BG105342A BG65179B1 (bg) 1998-12-14 2001-03-14 Оптичноактивно производно на пиридил-4н-1,2,4-оксадиазин и приложението му за производство на медикаменти за лечение на съдови заболявания
NO20012310A NO317649B1 (no) 1998-12-14 2001-05-10 Optisk aktiv pyridyl-4H-1,2,4-oksazdiazinderivat og dets anvendelse ved behandling av karsykdommer
JP2011128516A JP5620340B2 (ja) 1998-12-14 2011-06-08 光学活性ピリジル−４ｈ−１，２，４−オキサジアジン誘導体およびその血管疾患の治療における使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9802897A HU226617B1 (en) 1998-12-14 1998-12-14 Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient

Publications (4)

Publication Number Publication Date
HU9802897D0 HU9802897D0 (en) 1999-02-01
HUP9802897A2 true HUP9802897A2 (hu) 2000-11-28
HUP9802897A3 HUP9802897A3 (en) 2001-08-28
HU226617B1 HU226617B1 (en) 2009-04-28

Family

ID=10991166

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802897A HU226617B1 (en) 1998-12-14 1998-12-14 Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient

Country Status (27)

Country Link
US (1) US6384029B1 (hu)
EP (1) EP1147105B1 (hu)
JP (2) JP2002532498A (hu)
KR (1) KR100661774B1 (hu)
AT (1) ATE266027T1 (hu)
AU (1) AU765336B2 (hu)
BG (1) BG65179B1 (hu)
BR (1) BR9913982A (hu)
CA (1) CA2340734C (hu)
CZ (1) CZ300764B6 (hu)
DE (1) DE69917074T2 (hu)
DK (1) DK1147105T3 (hu)
EE (1) EE04551B1 (hu)
ES (1) ES2219091T3 (hu)
HR (1) HRP20010133B1 (hu)
HU (1) HU226617B1 (hu)
IL (1) IL141515A (hu)
NO (1) NO317649B1 (hu)
PL (1) PL196584B1 (hu)
PT (1) PT1147105E (hu)
RS (1) RS50129B (hu)
RU (1) RU2222538C2 (hu)
SI (1) SI1147105T1 (hu)
SK (1) SK285582B6 (hu)
UA (1) UA70340C2 (hu)
WO (1) WO2000035914A1 (hu)
ZA (1) ZA200101182B (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS60604A (en) 2002-01-11 2006-12-15 Biorex Kutato Es Feyleszto Rt. Carboxamidine derivatives and their use in the treatment of vascular diseases
KR100678577B1 (ko) * 2006-09-11 2007-02-06 조만규 가정용 분전함
BR122019024895B8 (pt) 2008-06-26 2021-07-27 Orphazyme As uso de um agente bioativo capaz de aumentar a concentração intracelular de hsp70
WO2010058779A1 (ja) 2008-11-18 2010-05-27 参天製薬株式会社 ピリジン－３－カルバルデヒド ｏ－（ピペリジン－１－イル－プロピル）－オキシム誘導体を有効成分として含有する網脈絡膜変性疾患の治療剤
AU2011335545A1 (en) 2010-11-30 2013-06-13 Orphazyme Aps Methods for increasing intracellular activity of Hsp70
HUP1100534A2 (en) 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
BR112017004948A2 (pt) 2014-09-15 2017-12-05 Orphazyme Aps formulação farmacêutica.
US10898476B2 (en) 2016-04-13 2021-01-26 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
US20190111041A1 (en) 2016-04-29 2019-04-18 Orphazyme A/S Arimoclomol for treating glucocerebrosidase associated disorders
EP3630105A1 (en) 2017-05-24 2020-04-08 Orphazyme A/S Heat shock protein inducers and frontotemporal disorders
SG11202011592SA (en) 2018-05-28 2020-12-30 Orphazyme As Hsp70 protein levels in pbmc samples as biomarker for disease
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
DE69628320D1 (de) * 1995-11-03 2003-06-26 Summit Packaging Systems Ltd Vorrichtung zum abgeben und füllen von beuteln an einem kassenplatz eines supermarkts
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells

Also Published As

Publication number Publication date
RS50129B (sr) 2009-03-25
AU1790600A (en) 2000-07-03
JP5620340B2 (ja) 2014-11-05
DK1147105T3 (da) 2004-06-01
BR9913982A (pt) 2001-06-12
EP1147105A1 (en) 2001-10-24
CA2340734A1 (en) 2000-06-22
JP2002532498A (ja) 2002-10-02
EE200100188A (et) 2002-08-15
EP1147105B1 (en) 2004-05-06
PL196584B1 (pl) 2008-01-31
RU2222538C2 (ru) 2004-01-27
SI1147105T1 (en) 2004-08-31
CZ20011550A3 (cs) 2001-08-15
DE69917074T2 (de) 2005-05-12
NO317649B1 (no) 2004-11-29
NO20012310D0 (no) 2001-05-10
NO20012310L (no) 2001-05-10
IL141515A (en) 2005-09-25
WO2000035914A1 (en) 2000-06-22
PT1147105E (pt) 2004-07-30
AU765336B2 (en) 2003-09-18
YU25001A (sh) 2004-07-15
ZA200101182B (en) 2002-02-12
PL346767A1 (en) 2002-02-25
IL141515A0 (en) 2002-03-10
KR100661774B1 (ko) 2006-12-28
HRP20010133A2 (en) 2002-02-28
CZ300764B6 (cs) 2009-08-05
BG105342A (en) 2001-12-29
US6384029B1 (en) 2002-05-07
JP2011201916A (ja) 2011-10-13
KR20010073129A (ko) 2001-07-31
HRP20010133B1 (en) 2005-02-28
BG65179B1 (bg) 2007-05-31
ATE266027T1 (de) 2004-05-15
CA2340734C (en) 2008-10-21
SK285582B6 (sk) 2007-04-05
HU9802897D0 (en) 1999-02-01
HUP9802897A3 (en) 2001-08-28
UA70340C2 (en) 2004-10-15
DE69917074D1 (de) 2004-06-09
HU226617B1 (en) 2009-04-28
EE04551B1 (et) 2005-10-17
SK2342001A3 (en) 2001-08-06
ES2219091T3 (es) 2004-11-16

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Owner name: CYTRX CORPORATION, US

Free format text: FORMER OWNER(S): BIOREX KUTATO ES FEJLESZTOE RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees