ES2155452T3 - Isoquinoindazol-6-(2h)-onas sustituidas con 2-aminoalquil-5-aminoalquilamino con actividad antitumoral. - Google Patents
Isoquinoindazol-6-(2h)-onas sustituidas con 2-aminoalquil-5-aminoalquilamino con actividad antitumoral.Info
- Publication number
- ES2155452T3 ES2155452T3 ES93921290T ES93921290T ES2155452T3 ES 2155452 T3 ES2155452 T3 ES 2155452T3 ES 93921290 T ES93921290 T ES 93921290T ES 93921290 T ES93921290 T ES 93921290T ES 2155452 T3 ES2155452 T3 ES 2155452T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- phenyl
- replaced
- group
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- -1 HYDROGEN COMPOUND Chemical group 0.000 abstract 5
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical group C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE PRESENTAN COMPUESTOS DE FORMULA (I) DONDE R ES HIDROGENO O HIDROXI; X O Y ES UN ATOMO DE CARBONO Y EL OTRO ES UN ATOMO DE NITROGENO DE FORMA QUE CUANDO Y ES NITROGENO, R ES HIDROGENO; A Y B SON IGUALES O DIFERENTES Y SE SELECCIONAN DEL GRUPO C1-C10 ALQUILO O FENILALQUILO; C2-C10 ALQUILO TIENE UNO O DOS SUSTITUYENTES SELECCIONADOS DEL GRUPO COMPUESTO DE OR1 Y NR2R3; C2-C10 ALQUILO INTERRUMPIDO POR UNO O DOS ATOMOS DE OXIGENO O POR UN GRUPO -NR4- Y SIENDO TAL C2-C10 ALQUILO OPCIONALMENTE SUSTITUIDO POR UNO O DOS GRUPOS HIDROXI (OH) O NR2R3; R2 Y R3 PUEDEN SER IGUALES O DISTINTOS Y ESTAN SELECCIONADOS DEL GRUPO COMPUESTO POR HIDROGENO, C1-C10 ALQUILO, FENILALQUILO, FENIL, C2C10 ALQUILO SUSTITUIDO CON UNO O DOS GRUPOS HIDROXI (OH), O R2 Y R3 TOMADOS CONJUNTAMENTE CON EL ATOMO DE NITROGENO AL QUE ESTAN VINCULADOS FORMAN UN ANILLO DE ETILENEIMINA O UN ANILLO HETEROCICLICO DE 5- O 6- ELEMENTOS AROMATICO O NO-AROMATICO QUE OPCIONALMENTE CONTIENE OTRO HETEROATOMO COMO SULFURO, OXIGENO O NITROGENO; R4 SE SELECCIONA DEL GRUPO COMPUESTO POR HIDROGENO, C1-C10 ALQUILO, C2-C10 HIDROXIALQUILO, C2-C10 ALQUILO SUSTITUIDO POR NR2R3, FENILALQUILO, FENILO; R5 SE SELECCIONA DEL GRUPO COMPUESTO DE C1-C10 ALQUILO, FENILALQUILO; ASI COMO BASES LIBRES Y SUS SALES CON ACIDOS FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPONENTES HAN DEMOSTRADO POSEER ACTIVIDAD ANTITUMOR.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94160792A | 1992-09-08 | 1992-09-08 | |
| US08/103,641 US5519029A (en) | 1992-09-08 | 1993-08-11 | 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2155452T3 true ES2155452T3 (es) | 2001-05-16 |
Family
ID=26800681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93921290T Expired - Lifetime ES2155452T3 (es) | 1992-09-08 | 1993-09-08 | Isoquinoindazol-6-(2h)-onas sustituidas con 2-aminoalquil-5-aminoalquilamino con actividad antitumoral. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0662076B1 (es) |
| JP (1) | JP3497168B2 (es) |
| CN (1) | CN1051549C (es) |
| AT (1) | ATE200491T1 (es) |
| AU (1) | AU680431B2 (es) |
| CZ (1) | CZ288366B6 (es) |
| DE (1) | DE69330131T2 (es) |
| DK (1) | DK0662076T3 (es) |
| ES (1) | ES2155452T3 (es) |
| FI (1) | FI109538B (es) |
| GR (1) | GR3036175T3 (es) |
| HU (1) | HU220616B1 (es) |
| NO (1) | NO302618B1 (es) |
| PT (1) | PT662076E (es) |
| RU (1) | RU2130937C1 (es) |
| SG (1) | SG52494A1 (es) |
| WO (1) | WO1994006795A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5596097A (en) * | 1994-03-08 | 1997-01-21 | The University Of Vermont | Hetero-annulated indazoles |
| CA2226310A1 (en) * | 1995-07-06 | 1997-01-23 | University Of Vermont | New pyrido-thiopyranoindazoles with anti-tumor activity |
| IT1277576B1 (it) * | 1995-09-13 | 1997-11-11 | Boehringer Mannheim Italia | 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale |
| IT1286509B1 (it) * | 1996-11-29 | 1998-07-15 | Boehringer Mannheim Italia | Derivati 2, 3, 4, 7-tetraidropiridoindazolo-(1,4)benzodiazepinici aventi attivita' antitumorale |
| US5948896A (en) * | 1997-08-13 | 1999-09-07 | Gem Pharmaceuticals | Processes for preparing 13-deoxy anthracycline derivatives |
| US6747039B2 (en) | 2002-03-12 | 2004-06-08 | Albany Molecular Research, Inc. | Aza-benzothiopyranoindazoles with antitumor activity |
| CN103787970A (zh) * | 2014-01-14 | 2014-05-14 | 北京万全德众医药生物技术有限公司 | 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL69211A (en) * | 1982-07-23 | 1987-01-30 | Warner Lambert Co | Substituted anthra(1,9-cd)pyrazol-6(2h)-ones,their preparation and pharmaceutical compositions containing them |
| US5220026A (en) * | 1990-11-22 | 1993-06-15 | Kyowa Hakko Kogyo Co., Ltd. | Pyrazoloacridone derivatives |
-
1993
- 1993-09-08 WO PCT/US1993/008241 patent/WO1994006795A1/en not_active Ceased
- 1993-09-08 CN CN93117377A patent/CN1051549C/zh not_active Expired - Lifetime
- 1993-09-08 ES ES93921290T patent/ES2155452T3/es not_active Expired - Lifetime
- 1993-09-08 AU AU48441/93A patent/AU680431B2/en not_active Ceased
- 1993-09-08 SG SG1996005180A patent/SG52494A1/en unknown
- 1993-09-08 PT PT93921290T patent/PT662076E/pt unknown
- 1993-09-08 DK DK93921290T patent/DK0662076T3/da active
- 1993-09-08 RU RU95110932A patent/RU2130937C1/ru not_active IP Right Cessation
- 1993-09-08 DE DE69330131T patent/DE69330131T2/de not_active Expired - Lifetime
- 1993-09-08 HU HU9500676A patent/HU220616B1/hu not_active IP Right Cessation
- 1993-09-08 JP JP50810594A patent/JP3497168B2/ja not_active Expired - Fee Related
- 1993-09-08 CZ CZ1995598A patent/CZ288366B6/cs not_active IP Right Cessation
- 1993-09-08 EP EP93921290A patent/EP0662076B1/en not_active Expired - Lifetime
- 1993-09-08 AT AT93921290T patent/ATE200491T1/de not_active IP Right Cessation
-
1995
- 1995-03-06 FI FI951023A patent/FI109538B/fi not_active Application Discontinuation
- 1995-03-07 NO NO950877A patent/NO302618B1/no not_active IP Right Cessation
-
2001
- 2001-07-05 GR GR20010401024T patent/GR3036175T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994006795A1 (en) | 1994-03-31 |
| PT662076E (pt) | 2001-09-28 |
| CN1101046A (zh) | 1995-04-05 |
| FI951023A7 (fi) | 1995-03-31 |
| JPH08503933A (ja) | 1996-04-30 |
| RU2130937C1 (ru) | 1999-05-27 |
| ATE200491T1 (de) | 2001-04-15 |
| DE69330131T2 (de) | 2001-08-30 |
| FI109538B (fi) | 2002-08-30 |
| AU4844193A (en) | 1994-04-12 |
| HU9500676D0 (en) | 1995-04-28 |
| SG52494A1 (en) | 1998-09-28 |
| CZ59895A3 (en) | 1995-11-15 |
| DE69330131D1 (de) | 2001-05-17 |
| NO950877D0 (no) | 1995-03-07 |
| AU680431B2 (en) | 1997-07-31 |
| EP0662076B1 (en) | 2001-04-11 |
| EP0662076A1 (en) | 1995-07-12 |
| RU95110932A (ru) | 1996-12-27 |
| NO950877L (no) | 1995-05-08 |
| JP3497168B2 (ja) | 2004-02-16 |
| FI951023A0 (fi) | 1995-03-06 |
| HUT70145A (en) | 1995-09-28 |
| NO302618B1 (no) | 1998-03-30 |
| CN1051549C (zh) | 2000-04-19 |
| DK0662076T3 (da) | 2001-05-07 |
| GR3036175T3 (en) | 2001-10-31 |
| HU220616B1 (hu) | 2002-03-28 |
| CZ288366B6 (en) | 2001-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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