ES2056887T3 - Complejos de amino-antracenodiona-bis-platino, utiles como agentes antitumorales. - Google Patents

Complejos de amino-antracenodiona-bis-platino, utiles como agentes antitumorales.

Info

Publication number
ES2056887T3
ES2056887T3 ES88121072T ES88121072T ES2056887T3 ES 2056887 T3 ES2056887 T3 ES 2056887T3 ES 88121072 T ES88121072 T ES 88121072T ES 88121072 T ES88121072 T ES 88121072T ES 2056887 T3 ES2056887 T3 ES 2056887T3
Authority
ES
Spain
Prior art keywords
bis
platinum complexes
amino
antracenodiona
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88121072T
Other languages
English (en)
Inventor
Alessandro Pasini
Franco Zunino
Odoardo Tofanetti
Carmelo A Gandolfi
Sergio Tognella
Silvano Spinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics SpA
Original Assignee
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT23094/87A external-priority patent/IT1223537B/it
Priority claimed from IT8848492A external-priority patent/IT1235045B/it
Application filed by Boehringer Mannheim Italia SpA filed Critical Boehringer Mannheim Italia SpA
Application granted granted Critical
Publication of ES2056887T3 publication Critical patent/ES2056887T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

CONPLEJOS BIS-PLATINO DE FORMULA (I) EN DONDE A ES UN DISUSTITUTO 1,4 ANTRACENODIAN X,X''SON LIGADOS ELEGIDOS DE EL GRUPO CONSISTENTE EN CL, BR, OH, CH3, SOCH3OH O CH3SOCH3 HAL O TOMADOS TODOS JUNTOS DEL ANION DE UN ACIDO CORBONICO M ES 0, 0,5 O UN ENTERO DE 1 A 5; SOLV ES UN DISOLVENTE DE CRISTALIZACION; RA ES HIDROGENO, ALQUILO OPCIONALMENTE SUSTITUIDO DE OXIGENO INTERRUMPIDO. RB ES ALQUILO SUSTITUIDO OPCIONALEMENTE POR HIDROXIDO, CLOXI, POLICLOXI O GRUPOS AMINO Y N ES UN ENTERO DE 2 A 3. LOS COMPOENENTES I SON UTIOLIES COMO AGENTES ANTITUMONARES.
ES88121072T 1987-12-18 1988-12-16 Complejos de amino-antracenodiona-bis-platino, utiles como agentes antitumorales. Expired - Lifetime ES2056887T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT23094/87A IT1223537B (it) 1987-12-18 1987-12-18 Amino antracenedioni bis platino complessi utili come agenti antitumorali
IT8848492A IT1235045B (it) 1988-10-26 1988-10-26 Bis-platino complessi di amino-antracenedioni

Publications (1)

Publication Number Publication Date
ES2056887T3 true ES2056887T3 (es) 1994-10-16

Family

ID=26328335

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88121072T Expired - Lifetime ES2056887T3 (es) 1987-12-18 1988-12-16 Complejos de amino-antracenodiona-bis-platino, utiles como agentes antitumorales.

Country Status (8)

Country Link
US (1) US5145848A (es)
EP (2) EP0396588A1 (es)
JP (1) JPH03503046A (es)
AU (1) AU2817589A (es)
CA (1) CA1327355C (es)
DE (1) DE3880991T2 (es)
ES (1) ES2056887T3 (es)
WO (1) WO1989005815A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5107007A (en) * 1989-09-01 1992-04-21 The University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US5770591A (en) * 1986-07-25 1998-06-23 The University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US5380897A (en) * 1993-05-25 1995-01-10 Hoeschele; James D. Tri(platinum) complexes
US5409915A (en) * 1993-09-14 1995-04-25 The University Of Vermont And State Agricultural College Bis-platinum (IV) complexes as chemotherapeutic agents
ZA976421B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polyamine ligands as antitumor agents.
ZA976422B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
AU1608801A (en) 1999-11-15 2001-05-30 Parker Hughes Institute Diamino platinum (ii) antitumor complexes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296030A (en) * 1980-04-09 1981-10-20 American Cyanamid Company Metal chelates of 1,4-bis(substituted-amino-5,8-dihydroxy-anthraquinones
EP0169645A1 (en) * 1984-06-27 1986-01-29 Johnson Matthey Public Limited Company Platinum co-ordination compounds
IL76002A0 (en) * 1984-08-03 1985-12-31 Boehringer Biochemia Srl Amino-anthracenediones-platinum complexes useful as anti-cancer compounds

Also Published As

Publication number Publication date
EP0396588A1 (en) 1990-11-14
EP0320960B1 (en) 1993-05-12
US5145848A (en) 1992-09-08
JPH03503046A (ja) 1991-07-11
WO1989005815A1 (en) 1989-06-29
AU2817589A (en) 1989-07-19
DE3880991D1 (de) 1993-06-17
CA1327355C (en) 1994-03-01
EP0320960A1 (en) 1989-06-21
DE3880991T2 (de) 1994-01-05

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