ES460286A1 - Un procedimiento de preparacion de espiro(1,3-dioxolan-4,3) quinuclidina. - Google Patents

Un procedimiento de preparacion de espiro(1,3-dioxolan-4,3) quinuclidina.

Info

Publication number
ES460286A1
ES460286A1 ES460286A ES460286A ES460286A1 ES 460286 A1 ES460286 A1 ES 460286A1 ES 460286 A ES460286 A ES 460286A ES 460286 A ES460286 A ES 460286A ES 460286 A1 ES460286 A1 ES 460286A1
Authority
ES
Spain
Prior art keywords
dioxolane
spiro
quinuclidine compounds
quinuclidine
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES460286A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mundipharma AG
Original Assignee
Mundipharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mundipharma AG filed Critical Mundipharma AG
Publication of ES460286A1 publication Critical patent/ES460286A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento de preparación de espiro (1,3-dioxolan-4,3¿) quinuclidina de fórmula general: *** donde R1 está seleccionado del grupo que consta de hidrógeno, alcohilo y arilo y R2 está seleccionado de hidrógeno, alcohilo y arilo, que comprende hacer reaccionar metiluro de dimetilsulfoxonio con quinuclidin-3-ona para dar quinuclidin-3-epóxido y hacer reaccionar éste con un aldehilo R1-CHO o con una cetona R1-CO-R2, donde R1 y R2 son alcohilo o arilo, para dar el producto deseado.
ES460286A 1975-11-11 1977-06-30 Un procedimiento de preparacion de espiro(1,3-dioxolan-4,3) quinuclidina. Expired ES460286A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL48452A IL48452A (en) 1975-11-11 1975-11-11 Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
ES460286A1 true ES460286A1 (es) 1978-04-01

Family

ID=11048545

Family Applications (2)

Application Number Title Priority Date Filing Date
ES453161A Expired ES453161A1 (es) 1975-11-11 1976-11-10 Un procedimiento de preparacion de espiro (1,3-dioxolan-4,3)quinuclidinas.
ES460286A Expired ES460286A1 (es) 1975-11-11 1977-06-30 Un procedimiento de preparacion de espiro(1,3-dioxolan-4,3) quinuclidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES453161A Expired ES453161A1 (es) 1975-11-11 1976-11-10 Un procedimiento de preparacion de espiro (1,3-dioxolan-4,3)quinuclidinas.

Country Status (20)

Country Link
US (1) US4104397A (es)
JP (1) JPS5277092A (es)
AR (2) AR213102A1 (es)
AT (1) AT356652B (es)
AU (1) AU507660B2 (es)
BE (1) BE848228A (es)
CA (1) CA1071629A (es)
CH (1) CH626085A5 (es)
DE (1) DE2650845A1 (es)
DK (1) DK148744C (es)
ES (2) ES453161A1 (es)
FI (1) FI60015C (es)
FR (1) FR2331343A1 (es)
GB (1) GB1542494A (es)
IL (1) IL48452A (es)
MX (1) MX4395E (es)
NL (1) NL7612426A (es)
NO (1) NO145618C (es)
NZ (1) NZ182555A (es)
ZA (1) ZA766662B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2454056A1 (fr) * 1979-03-15 1980-11-07 Geissmann Robert Cheminee cinetique pouvant etre utilisee comme rotissoire
EP0189370A3 (de) * 1985-01-16 1988-01-27 Sandoz Ag Spiro-dioxolane, -dithiolane und -oxothiolane
JPS61167130A (ja) * 1985-01-17 1986-07-28 Nissan Motor Co Ltd 内燃機関の吸気装置
US4855290A (en) 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
DE3853758T2 (de) * 1987-10-05 1995-09-07 Yamanouchi Pharma Co Ltd Heterozyklische Spiroverbindungen und ihre Herstellung.
US4876260A (en) * 1987-10-28 1989-10-24 State Of Israel, Israel Institute Of Biological Research Oxathiolanes
GB8808433D0 (en) * 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
GB8816299D0 (en) * 1988-07-08 1988-08-10 Merck Sharp & Dohme Therapeutic agents
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
NZ500643A (en) 1997-05-30 2001-12-21 Neurosearch As Spiro-quinuclidine derivatives and their use in treating conditions responsive to nicotinic ACh receptor modulators
JP4564135B2 (ja) * 1999-07-26 2010-10-20 住友化学株式会社 高純度フェノチアジン化合物とその製造方法、およびその中間体の製造方法、並びにその中間体の原料の水和物と新規結晶
WO2008073067A1 (en) * 2006-08-02 2008-06-19 Janssen Pharmaceutica N.V. Novel spiro-quinuclidinyl derivatives for the treatment of the central nervous system disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681363A (en) * 1970-08-20 1972-08-01 Univ Temple Spiro(imidazolidine-4,3{40 -quinuclidine)-2,5-diones

Also Published As

Publication number Publication date
NZ182555A (en) 1979-01-11
NO763819L (es) 1977-05-12
US4104397A (en) 1978-08-01
FR2331343B1 (es) 1980-04-04
AT356652B (de) 1980-05-12
NO145618C (no) 1982-04-28
MX4395E (es) 1982-04-23
AU507660B2 (en) 1980-02-21
CH626085A5 (es) 1981-10-30
IL48452A (en) 1979-07-25
JPS6259113B2 (es) 1987-12-09
NO145618B (no) 1982-01-18
FI60015C (fi) 1981-11-10
CA1071629A (en) 1980-02-12
ATA839376A (de) 1979-10-15
ES453161A1 (es) 1977-11-01
BE848228A (fr) 1977-03-01
AR213102A1 (es) 1978-12-15
JPS5277092A (en) 1977-06-29
AR214652A1 (es) 1979-07-13
NL7612426A (nl) 1977-05-13
IL48452A0 (en) 1976-01-30
DE2650845A1 (de) 1977-05-18
AU1955476A (en) 1978-05-18
GB1542494A (en) 1979-03-21
FR2331343A1 (fr) 1977-06-10
FI60015B (fi) 1981-07-31
FI763151A7 (es) 1977-05-12
DK507276A (da) 1977-05-12
ZA766662B (en) 1977-10-26
DK148744C (da) 1986-02-03
DK148744B (da) 1985-09-16

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