ES8405757A1 - "un procedimiento para la preparacion de compuestos aromaticos hidroxilados". - Google Patents

"un procedimiento para la preparacion de compuestos aromaticos hidroxilados".

Info

Publication number
ES8405757A1
ES8405757A1 ES514725A ES514725A ES8405757A1 ES 8405757 A1 ES8405757 A1 ES 8405757A1 ES 514725 A ES514725 A ES 514725A ES 514725 A ES514725 A ES 514725A ES 8405757 A1 ES8405757 A1 ES 8405757A1
Authority
ES
Spain
Prior art keywords
processes
production
pharmaceutical compositions
compositions containing
amine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514725A
Other languages
English (en)
Other versions
ES514725A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of ES514725A0 publication Critical patent/ES514725A0/es
Publication of ES8405757A1 publication Critical patent/ES8405757A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS AROMATICOS HIDROXILADOS, DE FORMULA GENERAL (I), EN LA QUE D1 ES UN RADICAL; R1 ES HIDROGENO, ALCOHILO O FENILO; X REPRESENTA UNA CADENA -(CH2)N-, OPCIONALMENTE SUSTITUIDA CON HIDROXI; N ES UN NUMERO ENTERO COMPRENDIDO ENTRE 1 Y 7; D2 REPRESENTA HIDROGENO, ALCOHILO, FENILO O PIRIDILO; Y R2 ES HIDROGENO O ALCOHILO INFERIOR, Y SUS DERIVADOS FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN REDUCIR SELECTIVAMENTE CON UN AGENTE REDUCTOR ELECTROFILO O NUCLEOFILO UN COMPUESTO DE FORMULA (II), EN LA QUET1 Y T2 REPRESENTAN HIDROGENO U OXIGENO, CON LA CONDICION DE QUE AL MENOS UNO DE ELLOS ES OXIGENO; R1A Y R2A TIENEN EL MISMO SIGNIFICADO QUE R1 Y R2; D1A REPRESENTA UN RADICAL; XA TIENE EL MISMO SIGNIFICADO QUE X; Y D2A REPRESENTA UN RADICAL.DE APLICACION EN EL TRATAMIENTO DEL FALLO CARDIACO CONGESTIVO, EL FALLO RENAL Y LA ANGINA DE PECHO.
ES514725A 1981-08-05 1982-08-04 "un procedimiento para la preparacion de compuestos aromaticos hidroxilados". Expired ES8405757A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8123962 1981-08-05
GB8130595 1981-10-09
GB8130594 1981-10-09
GB8134551 1981-11-17

Publications (2)

Publication Number Publication Date
ES514725A0 ES514725A0 (es) 1984-06-16
ES8405757A1 true ES8405757A1 (es) 1984-06-16

Family

ID=27449264

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514725A Expired ES8405757A1 (es) 1981-08-05 1982-08-04 "un procedimiento para la preparacion de compuestos aromaticos hidroxilados".

Country Status (20)

Country Link
US (1) US5013760A (es)
EP (1) EP0072061B1 (es)
AU (1) AU538078B2 (es)
CA (1) CA1191846A (es)
CY (1) CY1428A (es)
DE (1) DE3263531D1 (es)
DK (1) DK163181C (es)
ES (1) ES8405757A1 (es)
FI (1) FI82238C (es)
GR (1) GR77995B (es)
HK (1) HK41388A (es)
IE (1) IE53827B1 (es)
IL (1) IL66449A (es)
LU (1) LU88284I2 (es)
MY (1) MY8700459A (es)
NL (1) NL930078I2 (es)
NO (1) NO154492C (es)
NZ (1) NZ201479A (es)
PT (1) PT75380B (es)
SG (1) SG46287G (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8301754D0 (en) * 1983-01-21 1983-02-23 Fisons Plc Formulation
AU561190B2 (en) * 1983-01-21 1987-04-30 Fisons Plc Aromatic amines
EP0142283B1 (en) * 1983-10-25 1991-01-30 FISONS plc Phenylethylamines, process for their preparation and compositions containing them
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
IL77594A (en) * 1985-01-15 1989-12-15 Glaxo Group Ltd 2-substituted-3,4-dihydroxyphenethylamine derivatives,their preparation and pharmaceutical compositions containing them
IL80682A0 (en) * 1985-11-20 1987-02-27 Fisons Plc Substituted 2-phenethylamine derivatives,their preparation and pharmaceutical compositions containing them
US5602174A (en) * 1986-02-15 1997-02-11 Beecham Wuefling Gmbh & Co. Treatment
GB8603765D0 (en) * 1986-02-15 1986-03-19 Beecham Wuelfung Gmbh & Co Kg Compounds
GB2192394A (en) * 1986-07-11 1988-01-13 Glaxo Group Ltd Amine derivatives
US5753714A (en) * 1987-02-03 1998-05-19 Merrell Pharmaceuticals Inc. Polyamine derivatives
EP0314725A1 (en) * 1987-05-19 1989-05-10 FISONS plc 2-(3,4-dihydroxyphenyl)ethylamines, their preparation and use as pharmaceutical
IT1254521B (it) * 1992-03-17 1995-09-25 Zambon Spa Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1271007B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
IT1271008B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
MX2011004263A (es) 2008-10-21 2011-06-17 Pment Llc Johnson & Johnson Pharmaceutical Res & Develo Modelo animal para evaluar la respuesta vasomotora in vivo.
CN105001103B (zh) * 2015-05-31 2017-11-03 江苏同禾药业有限公司 一种盐酸多培沙明中间体的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653977A (en) * 1953-09-29 Chxnx
US2739981A (en) * 1952-08-26 1956-03-27 American Home Prod Diamines and salts thereof
US2937185A (en) * 1956-08-13 1960-05-17 Lakeside Lab Inc Diamino alkanols and alkanones
US3013020A (en) * 1958-01-24 1961-12-12 Miles Lab N,n'-bis-phenyl-alkylene-diamines
GB1004071A (en) * 1961-07-03 1965-09-08 Council Scient Ind Res Substituted ª‰-phenethylamines and a process for the production thereof
GB1025699A (en) * 1965-01-08 1966-04-14 Boehringer & Soehne Gmbh New n,n-diphenyl-alkylene-ª‡,ªÏ-diamines
DE1768297B1 (de) * 1968-04-26 1971-12-16 Beiersdorf Ag Substituierte Alkylendiamine und deren Salze
US3867454A (en) * 1971-03-10 1975-02-18 Sterling Drug Inc 1,1-BRIDGED-BIS(N-aralkyl-2-aminoethanols)
US3933913A (en) * 1971-06-01 1976-01-20 Smithkline Corporation N,N'-bis[3-substituted-4-hydroxypheyl)-2-hydroxyethyl)]-polymethylenediamines
GB1440440A (en) * 1972-10-06 1976-06-23 Manuf Prod Pharma Tetrahydronaphthalene derivatives
NO743023L (es) * 1973-08-31 1975-03-24 Sandoz Ag
US3928323A (en) * 1973-12-18 1975-12-23 Millmaster Onyx Corp Anti-microbial quaternary ammonium co-polymers
US3960959A (en) * 1973-12-19 1976-06-01 Sandoz Ltd. N,N'-bis{6-[(3,4-dihydroxyphenyl)alkylamino]-hexyl}hexamethylenediamines and the salts thereof
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
US4163063A (en) * 1976-01-02 1979-07-31 University Of Iowa Research Foundation Aminotetralin adrenergic β-agonists
GB8301754D0 (en) * 1983-01-21 1983-02-23 Fisons Plc Formulation

Also Published As

Publication number Publication date
FI82238C (fi) 1991-02-11
IL66449A0 (en) 1982-12-31
ES514725A0 (es) 1984-06-16
DK163181C (da) 1992-06-22
CY1428A (en) 1988-09-02
US5013760A (en) 1991-05-07
IE53827B1 (en) 1989-03-15
FI822630A0 (fi) 1982-07-28
IE821872L (en) 1983-02-05
GR77995B (es) 1984-09-26
EP0072061B1 (en) 1985-05-15
NL930078I2 (nl) 1993-11-16
NO822671L (no) 1983-02-07
PT75380B (en) 1986-02-12
CA1191846A (en) 1985-08-13
NZ201479A (en) 1986-07-11
EP0072061A1 (en) 1983-02-16
SG46287G (en) 1987-11-13
MY8700459A (en) 1987-12-31
LU88284I2 (fr) 1994-05-04
HK41388A (en) 1988-06-10
PT75380A (en) 1982-09-01
IL66449A (en) 1986-12-31
NO154492B (no) 1986-06-23
NL930078I1 (nl) 1993-09-16
AU538078B2 (en) 1984-07-26
AU8670282A (en) 1983-02-10
DK349582A (da) 1983-02-06
DE3263531D1 (en) 1985-06-20
DK163181B (da) 1992-02-03
FI82238B (fi) 1990-10-31
FI822630L (fi) 1983-02-06
NO154492C (no) 1986-10-01

Similar Documents

Publication Publication Date Title
ES8405757A1 (es) "un procedimiento para la preparacion de compuestos aromaticos hidroxilados".
CA1262357A (en) N-HYDROXYL PROTECTIVE GROUPS AND METHOD FOR THE PREPARATION OF 3-ACYLAMINO-1-HYDROXY-2-AZETIDINONES
IL110216A (en) Valproic acid amide derivatives and pharmaceutical compositions containing them
ES8403923A1 (es) Procedimiento para la preparacion de derivados del acido metilendifosfonico
HUT57722A (en) Process for producing azaspiran derivatives and pharmaceutical compositions comprising such compounds
ES8207156A1 (es) Procedimiento para la preparacion de nuevas pirimidinonas .
ES8301927A1 (es) Procedimiento de preparacion de acidos azabiciclohexano car-boxilicos y de sus sales
EP0127877A3 (en) Process for preparing cyanhydrine derivatives containing phosphorus
ES460286A1 (es) Un procedimiento de preparacion de espiro(1,3-dioxolan-4,3) quinuclidina.
ES8301241A1 (es) Un procedimiento para la preparacion de nuevos compuestos de mercaptoorganosiloxano.
GR3001994T3 (en) A thiophene derivative and process for preparing the same
ES8206462A1 (es) Un metodo para preparar derivados de 2-oxoazetidina.
DE3267188D1 (en) Hydroxybenzylamino-aryl compounds, process for preparing and pharmaceutical compositions containing the same
ES478070A1 (es) Un procedimiento de preparacion de derivados bencilidenicos.
ES8401059A1 (es) Procedimiento para la preparacion de fenoleteres biciclicos.
ES8200689A1 (es) Un procedimiento para la produccion de analogos de cefalosporina.
ES8400406A1 (es) Procedimiento para preparar derivados de indano.
ES8400088A1 (es) Procedimiento para preparar derivados de fenantreno.
ES467861A1 (es) Procedimiento de preparacion de espiro-oxazolidinas esteroi-des y sus esteroisomeros.
ES8302702A1 (es) Procedimiento para la produccion de nuevos compuestos de lactama.
ES8101559A1 (es) Procedimiento para preparar soluciones concentradas y esta- bles en almacenamiento de aclaradores de bencimidazolio
GB1324687A (en) 3-amino-delta2-pyrazoline derivatives and process for the preparation thereof
ES8307222A1 (es) "un procedimiento para la preparacion enantioselectiva de derivados n-sustituidos de prolina".
DE3162110D1 (en) Cycloalkano-thiazolyloxamidic-acid derivatives, process for their preparation and pharmaceutical compositions containing them
JPS54138536A (en) O-(n-substituted aminomethyl)phenylaceticacid and its preparation