IT1271007B - Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare - Google Patents

Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare

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Publication number
IT1271007B
IT1271007B ITMI941868A ITMI941868A IT1271007B IT 1271007 B IT1271007 B IT 1271007B IT MI941868 A ITMI941868 A IT MI941868A IT MI941868 A ITMI941868 A IT MI941868A IT 1271007 B IT1271007 B IT 1271007B
Authority
IT
Italy
Prior art keywords
tetraidronaftalene
derivatives
amino
active
cardiovascular system
Prior art date
Application number
ITMI941868A
Other languages
English (en)
Inventor
Stefania Montanari
Paolo Cavalleri
Cristina Fraire
Gian Carlo Crancini
Mauro Napoletano
Francesco Santangelo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of ITMI941868A0 publication Critical patent/ITMI941868A0/it
Priority to ITMI941868A priority Critical patent/IT1271007B/it
Priority to US08/465,636 priority patent/US5674909A/en
Priority to NZ293258A priority patent/NZ293258A/en
Priority to ES95932708T priority patent/ES2168384T3/es
Priority to DK95932708T priority patent/DK0781126T3/da
Priority to CZ97765A priority patent/CZ76597A3/cs
Priority to PCT/EP1995/003562 priority patent/WO1996008228A2/en
Priority to KR1019970701644A priority patent/KR970705989A/ko
Priority to CA002199484A priority patent/CA2199484A1/en
Priority to AU35653/95A priority patent/AU694563B2/en
Priority to PT95932708T priority patent/PT781126E/pt
Priority to RU97106097/04A priority patent/RU2149158C1/ru
Priority to HU9701331A priority patent/HUT76837A/hu
Priority to AT95932708T priority patent/ATE210433T1/de
Priority to EP95932708A priority patent/EP0781126B1/en
Priority to DE69524610T priority patent/DE69524610T2/de
Priority to JP8509893A priority patent/JPH11501006A/ja
Publication of ITMI941868A1 publication Critical patent/ITMI941868A1/it
Priority to FI971039A priority patent/FI971039A0/fi
Priority to NO971134A priority patent/NO971134L/no
Application granted granted Critical
Publication of IT1271007B publication Critical patent/IT1271007B/it

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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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Abstract

Vengono descritti composti di formula (FORMULA I) In CUI R, R', R", R1 , R2, R3, R4, R5, R6, X, Y, m, n e p- hanno i significati riportati nella descrizione;e loro sali farmaceuticamente accettabili.I composti di formula I sono utili nel trattamento dell'ipertensione arteriosa e dello scompenso cardiaco, dell'insufficienza renale, delle arteriopatie periferiche, delle insufficienze cerebrovascolari e della cardiopatia ischemica.
ITMI941868A 1994-09-13 1994-09-13 Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare IT1271007B (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
ITMI941868A IT1271007B (it) 1994-09-13 1994-09-13 Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
US08/465,636 US5674909A (en) 1994-09-13 1995-06-06 Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system
PT95932708T PT781126E (pt) 1994-09-13 1995-09-11 Derivados de 2-amino-1,2,3,4-tetra-hidro naftalino activos no sistema cardiovascular
RU97106097/04A RU2149158C1 (ru) 1994-09-13 1995-09-11 Производные 2-амино-1,2,3,4-тетрагидронафталина, обладающие активностью в отношении сердечно-сосудистой системы, и фармацевтическая композиция
DK95932708T DK0781126T3 (da) 1994-09-13 1995-09-11 Derivater af 2-amino-1,2,3,4-tetrahydronaphthalen, der er aktive på det cardiovaskulære system
CZ97765A CZ76597A3 (en) 1994-09-13 1995-09-11 2-amino-1,2,3,4-tetrahydronaphthalene derivatives, process of their preparation and pharmaceutical composition containing thereof
PCT/EP1995/003562 WO1996008228A2 (en) 1994-09-13 1995-09-11 Derivatives of 2-amino-1,2,3,4-tetrahydro-naphthalene active on the cardiovascular system
KR1019970701644A KR970705989A (ko) 1994-09-13 1995-09-11 심장혈관계에 대해 활성인 2-아미노-1, 2, 3, 4-테트라히드로-나프탈렌의 유도체(derivatives of 2-amino-1, 2, 3, 4-tetrahydro-naphthalene active on the cardiovascular system)
CA002199484A CA2199484A1 (en) 1994-09-13 1995-09-11 Derivatives of 2-amino-1,2,3,4-tetrahydro-naphthalene active on the cardiovascular system
AU35653/95A AU694563B2 (en) 1994-09-13 1995-09-11 Derivatives of 2-amino-1,2,3,4-tetrahydro-naphthalene active on the cardiovascular system
NZ293258A NZ293258A (en) 1994-09-13 1995-09-11 2-amino-1,2,3,4-tetrahydronaphthalene derivatives
ES95932708T ES2168384T3 (es) 1994-09-13 1995-09-11 Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos para el sistema cardiovascular.
HU9701331A HUT76837A (en) 1994-09-13 1995-09-11 Derivatives of 2-amino-1,2,3,4-tetrahydro-naphthalene active on the cardiovascular system, pharmaceutical compositions containing them and process for their preparation
AT95932708T ATE210433T1 (de) 1994-09-13 1995-09-11 2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung
EP95932708A EP0781126B1 (en) 1994-09-13 1995-09-11 Derivatives of 2-amino-1,2,3,4-tetrahydro-naphthalene active on the cardiovascular system
DE69524610T DE69524610T2 (de) 1994-09-13 1995-09-11 2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung
JP8509893A JPH11501006A (ja) 1994-09-13 1995-09-11 心臓血管系に作用する２−アミノ−１，２，３，４−テトラヒドロナフタレン誘導体
FI971039A FI971039A0 (fi) 1994-09-13 1997-03-12 Sydän-verisuonijärjestelmään aktiivisesti vaikuttavat 2-amino-1,2,3,4-tetrahydronaftaleenijohdannaiset
NO971134A NO971134L (no) 1994-09-13 1997-03-12 Derivater av 2-amino-1,2,3,4-tetrahydronaftalen som er aktive på det kardiovaskulære system

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ITMI941868A IT1271007B (it) 1994-09-13 1994-09-13 Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare

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ITMI941868A0 ITMI941868A0 (it) 1994-09-13
ITMI941868A1 ITMI941868A1 (it) 1996-03-13
IT1271007B true IT1271007B (it) 1997-05-26

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EP (1) EP0781126B1 (it)
JP (1) JPH11501006A (it)
KR (1) KR970705989A (it)
AT (1) ATE210433T1 (it)
AU (1) AU694563B2 (it)
CA (1) CA2199484A1 (it)
CZ (1) CZ76597A3 (it)
DE (1) DE69524610T2 (it)
DK (1) DK0781126T3 (it)
ES (1) ES2168384T3 (it)
FI (1) FI971039A0 (it)
HU (1) HUT76837A (it)
IT (1) IT1271007B (it)
NO (1) NO971134L (it)
NZ (1) NZ293258A (it)
PT (1) PT781126E (it)
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WO (1) WO1996008228A2 (it)

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IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1289980B1 (it) * 1997-02-26 1998-10-19 Zambon Spa Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare
EP1085009B1 (en) * 1998-06-03 2004-11-10 Nissan Chemical Industries, Ltd. Indan derivatives
DE10109859A1 (de) * 2001-03-01 2002-09-05 Bayer Ag Neuartige Aminodicarbonsäurederivate
GB2389582A (en) * 2002-06-13 2003-12-17 Bayer Ag Pharmaceutically active carboxamides
JP2006523674A (ja) * 2003-04-18 2006-10-19 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 慢性閉塞性肺疾患（ｃｏｐｄ）のための組合せ治療法
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
KR101589551B1 (ko) 2005-07-15 2016-02-02 알바니 몰레큘라 리써치, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
WO2008141081A1 (en) * 2007-05-10 2008-11-20 Amr Technology, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
JP6163105B2 (ja) 2010-11-16 2017-07-12 ユニバーシティー オブ サザン カリフォルニア 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤
US10874669B2 (en) 2012-11-29 2020-12-29 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases
EP2925755B1 (en) * 2012-11-29 2021-09-08 Wayne State University Neuroprotective agents for the treatment of neurodegenerative diseases
US11285147B2 (en) 2018-09-07 2022-03-29 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases

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US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
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IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

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EP0781126A2 (en) 1997-07-02
DE69524610D1 (de) 2002-01-24
DE69524610T2 (de) 2002-07-18
HUT76837A (en) 1997-11-28
WO1996008228A3 (en) 1996-07-25
KR970705989A (ko) 1997-11-03
WO1996008228A2 (en) 1996-03-21
NO971134L (no) 1997-05-12
ITMI941868A0 (it) 1994-09-13
FI971039A (fi) 1997-03-12
CZ76597A3 (en) 1997-10-15
JPH11501006A (ja) 1999-01-26
NO971134D0 (no) 1997-03-12
US5674909A (en) 1997-10-07
ITMI941868A1 (it) 1996-03-13
AU3565395A (en) 1996-03-29
RU2149158C1 (ru) 2000-05-20
CA2199484A1 (en) 1996-03-21
ES2168384T3 (es) 2002-06-16
EP0781126B1 (en) 2001-12-12
AU694563B2 (en) 1998-07-23
PT781126E (pt) 2002-06-28
DK0781126T3 (da) 2002-04-08
FI971039A0 (fi) 1997-03-12
ATE210433T1 (de) 2001-12-15
NZ293258A (en) 1998-06-26

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