DE69524610D1 - 2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung - Google Patents

2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung

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Publication number
DE69524610D1
DE69524610D1 DE69524610T DE69524610T DE69524610D1 DE 69524610 D1 DE69524610 D1 DE 69524610D1 DE 69524610 T DE69524610 T DE 69524610T DE 69524610 T DE69524610 T DE 69524610T DE 69524610 D1 DE69524610 D1 DE 69524610D1
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tetrahydronaphtaline
derivatives
amino
cardiovascular effect
compounds
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DE69524610T
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DE69524610T2 (de
Inventor
Stefania Montanari
Paolo Cavalleri
Cristina Fraire
Carlo Grancini
Mauro Napoletano
Francesco Santangelo
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Zambon SpA
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Zambon SpA
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    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

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DE69524610T 1994-09-13 1995-09-11 2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung Expired - Fee Related DE69524610T2 (de)

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ITMI941868A IT1271007B (it) 1994-09-13 1994-09-13 Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
PCT/EP1995/003562 WO1996008228A2 (en) 1994-09-13 1995-09-11 Derivatives of 2-amino-1,2,3,4-tetrahydro-naphthalene active on the cardiovascular system

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DE69524610D1 true DE69524610D1 (de) 2002-01-24
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JP (1) JPH11501006A (de)
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IT (1) IT1271007B (de)
NO (1) NO971134L (de)
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IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1289980B1 (it) 1997-02-26 1998-10-19 Zambon Spa Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare
EP1085009B1 (de) * 1998-06-03 2004-11-10 Nissan Chemical Industries, Ltd. Indanderivate
DE10109859A1 (de) * 2001-03-01 2002-09-05 Bayer Ag Neuartige Aminodicarbonsäurederivate
GB2389582A (en) * 2002-06-13 2003-12-17 Bayer Ag Pharmaceutically active carboxamides
CA2522666A1 (en) * 2003-04-18 2004-10-28 Pharmacia & Upjohn Company Llc Combination therapies for chronic obstructive pulmonary disease (copd)
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
KR20080044840A (ko) 2005-07-15 2008-05-21 에이엠알 테크놀로지, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도
MX2009011923A (es) * 2007-05-10 2009-11-18 Amr Technology Inc Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.
CA2817975C (en) 2010-11-16 2020-03-31 Michael Kahn Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells
WO2014085600A1 (en) * 2012-11-29 2014-06-05 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases
US10874669B2 (en) 2012-11-29 2020-12-29 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases
US11285147B2 (en) 2018-09-07 2022-03-29 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases

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DK131775A (de) * 1974-03-28 1975-09-29 Wellcome Found
DE3263531D1 (en) * 1981-08-05 1985-06-20 Fisons Plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
EP0142283B1 (de) * 1983-10-25 1991-01-30 FISONS plc Phenylethylamine, Verfahren zu deren Herstellung und diese enthaltende Zusammensetzungen
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
IT1224405B (it) * 1987-12-23 1990-10-04 Simes Composti attivi sul sistema cardiovascolare
US5358971A (en) * 1989-07-05 1994-10-25 Whitby Research, Inc. Substituted 2-aminotetralins
IT1254521B (it) * 1992-03-17 1995-09-25 Zambon Spa Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

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RU2149158C1 (ru) 2000-05-20
NO971134D0 (no) 1997-03-12
JPH11501006A (ja) 1999-01-26
EP0781126A2 (de) 1997-07-02
AU694563B2 (en) 1998-07-23
FI971039A (fi) 1997-03-12
NO971134L (no) 1997-05-12
WO1996008228A2 (en) 1996-03-21
CA2199484A1 (en) 1996-03-21
CZ76597A3 (en) 1997-10-15
ES2168384T3 (es) 2002-06-16
KR970705989A (ko) 1997-11-03
ITMI941868A0 (it) 1994-09-13
DK0781126T3 (da) 2002-04-08
NZ293258A (en) 1998-06-26
ITMI941868A1 (it) 1996-03-13
EP0781126B1 (de) 2001-12-12
DE69524610T2 (de) 2002-07-18
HUT76837A (en) 1997-11-28
US5674909A (en) 1997-10-07
WO1996008228A3 (en) 1996-07-25
PT781126E (pt) 2002-06-28
AU3565395A (en) 1996-03-29
IT1271007B (it) 1997-05-26
ATE210433T1 (de) 2001-12-15
FI971039A0 (fi) 1997-03-12

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