ATE210433T1 - 2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung - Google Patents

2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung

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Publication number
ATE210433T1
ATE210433T1 AT95932708T AT95932708T ATE210433T1 AT E210433 T1 ATE210433 T1 AT E210433T1 AT 95932708 T AT95932708 T AT 95932708T AT 95932708 T AT95932708 T AT 95932708T AT E210433 T1 ATE210433 T1 AT E210433T1
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Prior art keywords
tetrahydronaphtaline
derivatives
amino
cardiovascular action
compounds
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Application number
AT95932708T
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English (en)
Inventor
Stefania Montanari
Paolo Cavalleri
Cristina Fraire
Gian Carlo Grancini
Mauro Napoletano
Francesco Santangelo
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Zambon Spa
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Publication of ATE210433T1 publication Critical patent/ATE210433T1/de

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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

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AT95932708T 1994-09-13 1995-09-11 2-amino-1,2,3,4-tetrahydronaphtalin derivate mit cardiovaskularer wirkung ATE210433T1 (de)

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ITMI941868A IT1271007B (it) 1994-09-13 1994-09-13 Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
PCT/EP1995/003562 WO1996008228A2 (en) 1994-09-13 1995-09-11 Derivatives of 2-amino-1,2,3,4-tetrahydro-naphthalene active on the cardiovascular system

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ATE210433T1 true ATE210433T1 (de) 2001-12-15

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JP (1) JPH11501006A (de)
KR (1) KR970705989A (de)
AT (1) ATE210433T1 (de)
AU (1) AU694563B2 (de)
CA (1) CA2199484A1 (de)
CZ (1) CZ76597A3 (de)
DE (1) DE69524610T2 (de)
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ES (1) ES2168384T3 (de)
FI (1) FI971039A (de)
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IT (1) IT1271007B (de)
NO (1) NO971134L (de)
NZ (1) NZ293258A (de)
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IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1289980B1 (it) * 1997-02-26 1998-10-19 Zambon Spa Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare
US6486178B1 (en) * 1998-06-03 2002-11-26 Nissan Chemical Industries, Ltd. Indane derivatives
DE10109859A1 (de) * 2001-03-01 2002-09-05 Bayer Ag Neuartige Aminodicarbonsäurederivate
GB2389582A (en) * 2002-06-13 2003-12-17 Bayer Ag Pharmaceutically active carboxamides
EP1620083A2 (de) * 2003-04-18 2006-02-01 Pharmacia & Upjohn Company LLC Kombinationstherapien
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
KR101594898B1 (ko) 2005-07-15 2016-02-18 알바니 몰레큘라 리써치, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
MX2009011923A (es) * 2007-05-10 2009-11-18 Amr Technology Inc Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.
BR112013012228B1 (pt) * 2010-11-16 2023-02-28 University Of Southern California Método cosmético para tratar uma condição da pele e usos de um composto antagonista de cbp/catenina de molécula pequena
US10874669B2 (en) 2012-11-29 2020-12-29 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases
WO2014085600A1 (en) * 2012-11-29 2014-06-05 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases
US11285147B2 (en) 2018-09-07 2022-03-29 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases

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DK131775A (de) * 1974-03-28 1975-09-29 Wellcome Found
EP0072061B1 (de) * 1981-08-05 1985-05-15 FISONS plc Aminderivate, Verfahren zu deren Produktion und diese enthaltende pharmazeutische Zusammensetzungen
EP0142283B1 (de) * 1983-10-25 1991-01-30 FISONS plc Phenylethylamine, Verfahren zu deren Herstellung und diese enthaltende Zusammensetzungen
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
IT1224405B (it) * 1987-12-23 1990-10-04 Simes Composti attivi sul sistema cardiovascolare
US5358971A (en) * 1989-07-05 1994-10-25 Whitby Research, Inc. Substituted 2-aminotetralins
IT1254521B (it) * 1992-03-17 1995-09-25 Zambon Spa Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

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CZ76597A3 (en) 1997-10-15
WO1996008228A3 (en) 1996-07-25
IT1271007B (it) 1997-05-26
DE69524610D1 (de) 2002-01-24
PT781126E (pt) 2002-06-28
WO1996008228A2 (en) 1996-03-21
ITMI941868A1 (it) 1996-03-13
FI971039A0 (fi) 1997-03-12
ITMI941868A0 (it) 1994-09-13
AU694563B2 (en) 1998-07-23
DE69524610T2 (de) 2002-07-18
JPH11501006A (ja) 1999-01-26
FI971039A (fi) 1997-03-12
DK0781126T3 (da) 2002-04-08
KR970705989A (ko) 1997-11-03
EP0781126A2 (de) 1997-07-02
ES2168384T3 (es) 2002-06-16
HUT76837A (en) 1997-11-28
AU3565395A (en) 1996-03-29
EP0781126B1 (de) 2001-12-12
CA2199484A1 (en) 1996-03-21
RU2149158C1 (ru) 2000-05-20
NZ293258A (en) 1998-06-26
NO971134D0 (no) 1997-03-12
NO971134L (no) 1997-05-12
US5674909A (en) 1997-10-07

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