IT1271009B - Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare - Google Patents
Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolareInfo
- Publication number
- IT1271009B IT1271009B ITMI941870A ITMI941870A IT1271009B IT 1271009 B IT1271009 B IT 1271009B IT MI941870 A ITMI941870 A IT MI941870A IT MI941870 A ITMI941870 A IT MI941870A IT 1271009 B IT1271009 B IT 1271009B
- Authority
- IT
- Italy
- Prior art keywords
- benzothiopyrane
- benzopyrane
- cardiovascular system
- formula
- derivatives active
- Prior art date
Links
- ONJRTQUWKRDCTA-UHFFFAOYSA-N 2h-thiochromene Chemical class C1=CC=C2C=CCSC2=C1 ONJRTQUWKRDCTA-UHFFFAOYSA-N 0.000 title 1
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 title 1
- 210000000748 cardiovascular system Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010058842 Cerebrovascular insufficiency Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 abstract 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Vengono descritti composti di formula (FORMULA I) in cui R, R', R", Z, m, Y, n, R1, X, p e Ar hanno i significati riportati nella descrizione;e loro sali farmaceuticamente accettabili.I composti di formula I sono utili nel trattamento dell'ipertensione arteriosa e dello scompenso cardiaco, dell'insufficienza renale, delle arteriopatie periferiche. delle insufficienze cerebrovascolari e della cardiopatia ischemica.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941870A IT1271009B (it) | 1994-09-13 | 1994-09-13 | Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare |
PCT/EP1995/003478 WO1996008489A1 (en) | 1994-09-13 | 1995-09-05 | Derivatives of benzopyran and of benzothiopyran, their preparation and their use as agonists of dopaminergic receptors |
JP8509870A JPH10505095A (ja) | 1994-09-13 | 1995-09-05 | ベンゾピラン誘導体及びベンゾチオピラン誘導体、その製法、及びドーパミン作動性レセプターの作動薬としてのその使用 |
DE69528770T DE69528770T2 (de) | 1994-09-13 | 1995-09-05 | Derivate des benzopyrans und des benzothiopyrans, deren herstellung und deren verwendung als agonisten von dopamin rezeptoren |
AU35216/95A AU3521695A (en) | 1994-09-13 | 1995-09-05 | Derivatives of benzopyran and of benzothiopyran, their preparation and their use as agonists of dopaminergic receptors |
EP95931987A EP0781280B1 (en) | 1994-09-13 | 1995-09-05 | Derivatives of benzopyran and of benzothiopyran, their preparation and their use as agonists of dopaminergic receptors |
AT95931987T ATE227287T1 (de) | 1994-09-13 | 1995-09-05 | Derivate des benzopyrans und des benzothiopyrans, deren herstellung und deren verwendung als agonisten von dopamin rezeptoren |
ES95931987T ES2185716T3 (es) | 1994-09-13 | 1995-09-05 | Derivados del benzopirano y del bezotiopirano, su preparacion y su uso como agonistas de los receptores dopaminergico. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941870A IT1271009B (it) | 1994-09-13 | 1994-09-13 | Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941870A0 ITMI941870A0 (it) | 1994-09-13 |
ITMI941870A1 ITMI941870A1 (it) | 1996-03-13 |
IT1271009B true IT1271009B (it) | 1997-05-26 |
Family
ID=11369550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941870A IT1271009B (it) | 1994-09-13 | 1994-09-13 | Derivati del benzopirano e del benzotiopirano attivi sul sistema cardiovascolare |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0781280B1 (it) |
JP (1) | JPH10505095A (it) |
AT (1) | ATE227287T1 (it) |
AU (1) | AU3521695A (it) |
DE (1) | DE69528770T2 (it) |
ES (1) | ES2185716T3 (it) |
IT (1) | IT1271009B (it) |
WO (1) | WO1996008489A1 (it) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7125904B2 (en) | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
GB0426061D0 (en) * | 2004-11-26 | 2004-12-29 | Pfizer Ltd | Chroman compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4801605A (en) * | 1986-08-29 | 1989-01-31 | Ciba-Geigy Corporation | 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans |
IT1224405B (it) * | 1987-12-23 | 1990-10-04 | Simes | Composti attivi sul sistema cardiovascolare |
CA2047236C (en) * | 1989-04-27 | 1997-07-22 | Bengt Ronny Andersson | Substituted 3-amino chromans |
IT1254521B (it) * | 1992-03-17 | 1995-09-25 | Zambon Spa | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
IT1271411B (it) * | 1993-09-14 | 1997-05-28 | Zambon Spa | Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare |
-
1994
- 1994-09-13 IT ITMI941870A patent/IT1271009B/it active IP Right Grant
-
1995
- 1995-09-05 WO PCT/EP1995/003478 patent/WO1996008489A1/en active IP Right Grant
- 1995-09-05 AU AU35216/95A patent/AU3521695A/en not_active Abandoned
- 1995-09-05 AT AT95931987T patent/ATE227287T1/de not_active IP Right Cessation
- 1995-09-05 DE DE69528770T patent/DE69528770T2/de not_active Expired - Fee Related
- 1995-09-05 JP JP8509870A patent/JPH10505095A/ja not_active Ceased
- 1995-09-05 EP EP95931987A patent/EP0781280B1/en not_active Expired - Lifetime
- 1995-09-05 ES ES95931987T patent/ES2185716T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH10505095A (ja) | 1998-05-19 |
ES2185716T3 (es) | 2003-05-01 |
EP0781280A1 (en) | 1997-07-02 |
DE69528770T2 (de) | 2003-07-17 |
ATE227287T1 (de) | 2002-11-15 |
ITMI941870A0 (it) | 1994-09-13 |
EP0781280B1 (en) | 2002-11-06 |
WO1996008489A1 (en) | 1996-03-21 |
AU3521695A (en) | 1996-03-29 |
DE69528770D1 (de) | 2002-12-12 |
ITMI941870A1 (it) | 1996-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970825 |