ES8505379A1 - Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos - Google Patents
Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatosInfo
- Publication number
- ES8505379A1 ES8505379A1 ES530248A ES530248A ES8505379A1 ES 8505379 A1 ES8505379 A1 ES 8505379A1 ES 530248 A ES530248 A ES 530248A ES 530248 A ES530248 A ES 530248A ES 8505379 A1 ES8505379 A1 ES 8505379A1
- Authority
- ES
- Spain
- Prior art keywords
- dihydropyridine
- derivatives
- production
- compounds
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
METODO DE FABRICAR 1,4-DIHIDROPIRIDINA-3-CARBOXILATOS.COMPRENDE: A) MEZCLAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) O ENAMINOESTER DE (III) Y CON UN DERIVADO BENZALDEHIDICO DE FORMULA (IV), EN UNA PROPORCION MOLAR DE 0,8 : 0,8 : 1 A 4 : 4 : 1, Y B) HACER REACCIONAR LA MEZCLA A UNA TEMPERATURA ENTRE 40J Y 100JC Y EN AUSENCIA O PRESENCIA DE ALCOHOLES, HIDROCARBUROS AROMATICOS, HIDROCARBUROS HALOGENADOS Y OTROS PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES. SIENDO R1, R2 Y R4, H, UN RESTOS HIDROCARBONADO DE C 1 A 10 COMPUESTO POR VARIAS CADENAS (RAMIFICADAS O NO RAMIFICADAS) Y OTROS; R3 Y R5 UN ALQUILO INFERIOR, Y R6 Y R7, H, NITRO, CIANO, TRIFLUORMETILO Y OTROS.SE UTILIZAN COMO VASODILATADORES E HIPOTENSORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58036211A JPS59161392A (ja) | 1983-03-04 | 1983-03-04 | ジヒドロピリジン誘導体及びその製法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8505379A1 true ES8505379A1 (es) | 1985-05-16 |
ES530248A0 ES530248A0 (es) | 1985-05-16 |
Family
ID=12463415
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530248A Granted ES530248A0 (es) | 1983-03-04 | 1984-03-02 | Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos |
ES537717A Expired ES8603902A1 (es) | 1983-03-04 | 1984-11-16 | Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537717A Expired ES8603902A1 (es) | 1983-03-04 | 1984-11-16 | Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos |
Country Status (8)
Country | Link |
---|---|
US (1) | US4535073A (es) |
EP (1) | EP0121117B1 (es) |
JP (1) | JPS59161392A (es) |
KR (1) | KR840007882A (es) |
CA (1) | CA1254206A (es) |
DE (1) | DE3479582D1 (es) |
ES (2) | ES530248A0 (es) |
GB (1) | GB2140015B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6069089A (ja) * | 1983-09-26 | 1985-04-19 | Nissan Chem Ind Ltd | ジヒドロピリジン−5−ホスホネ−ト誘導体およびその製造法 |
JPS6130591A (ja) * | 1984-07-20 | 1986-02-12 | Nissan Chem Ind Ltd | ジヒドロピリジン−5−ホスホネ−ト誘導体 |
DE3477669D1 (en) * | 1983-09-26 | 1989-05-18 | Nissan Chemical Ind Ltd | Dihydropyridine-5-phosphonic acid cyclic ester |
EP0141221A1 (en) * | 1983-09-26 | 1985-05-15 | Nissan Chemical Industries Ltd. | 1,4-Dihydropyridine-5-phosphonic acid ester |
JPS60248693A (ja) * | 1984-04-19 | 1985-12-09 | Nippon Shinyaku Co Ltd | ピリジン誘導体及び製法 |
JPS6127995A (ja) * | 1984-07-18 | 1986-02-07 | Nissan Chem Ind Ltd | ジヒドロピリジン−5−ホスホン酸モノエステル誘導体およびその製造法 |
IT1201444B (it) * | 1985-08-01 | 1989-02-02 | Boehringer Biochemia Srl | Fosfonopiridine a loro 1,4-diidroderivati |
IT1215298B (it) * | 1985-08-06 | 1990-01-31 | Boehringer Biochemia Srl | 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione. |
CN1016063B (zh) | 1986-01-22 | 1992-04-01 | 日产化学工业株式会社 | 二氢吡啶-5-膦酸环亚丙基酯的制备 |
US4885284A (en) * | 1986-01-22 | 1989-12-05 | Nissan Chemical Industries Ltd. | Dihydropyridine-5-phosphonic acid cyclic propylene ester |
JPH0699458B2 (ja) * | 1986-01-23 | 1994-12-07 | 日産化学工業株式会社 | ジヒドロピリジン−5−ホスホン酸環状エステル類 |
JPS63115890A (ja) * | 1986-10-31 | 1988-05-20 | Nippon Shinyaku Co Ltd | 2位置換1,4−ジヒドロピリジン誘導体 |
US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
CA1334752C (en) * | 1988-08-02 | 1995-03-14 | Ryozo Sakoda | Drug effect-enhancing agent for antitumor drug |
JP2850376B2 (ja) * | 1988-08-02 | 1999-01-27 | 日産化学工業株式会社 | 抗癌剤薬効増強剤 |
AU2004226547B2 (en) * | 2003-03-28 | 2008-10-23 | Nissan Chemical Industries,Ltd. | T-Type calcium channel blockers |
MX360640B (es) | 2010-03-01 | 2018-11-09 | Tau Therapeutics Llc Star | Diagnosis e imagenologia de cancer. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
-
1983
- 1983-03-04 JP JP58036211A patent/JPS59161392A/ja active Granted
-
1984
- 1984-02-20 GB GB08404386A patent/GB2140015B/en not_active Expired
- 1984-03-02 US US06/585,574 patent/US4535073A/en not_active Expired - Fee Related
- 1984-03-02 DE DE8484102249T patent/DE3479582D1/de not_active Expired
- 1984-03-02 ES ES530248A patent/ES530248A0/es active Granted
- 1984-03-02 CA CA000448718A patent/CA1254206A/en not_active Expired
- 1984-03-02 EP EP84102249A patent/EP0121117B1/en not_active Expired
- 1984-03-03 KR KR1019840001072A patent/KR840007882A/ko not_active Application Discontinuation
- 1984-11-16 ES ES537717A patent/ES8603902A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES537717A0 (es) | 1986-01-01 |
EP0121117A1 (en) | 1984-10-10 |
GB8404386D0 (en) | 1984-03-28 |
US4535073A (en) | 1985-08-13 |
JPS59161392A (ja) | 1984-09-12 |
DE3479582D1 (en) | 1989-10-05 |
GB2140015A (en) | 1984-11-21 |
EP0121117B1 (en) | 1989-08-30 |
GB2140015B (en) | 1987-07-29 |
KR840007882A (ko) | 1984-12-11 |
CA1254206A (en) | 1989-05-16 |
ES8603902A1 (es) | 1986-01-01 |
JPH0365351B2 (es) | 1991-10-11 |
ES530248A0 (es) | 1985-05-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8505379A1 (es) | Un metodo de fabricar 1, 4-dihidropiridina-3-carboxilatos | |
HUT47217A (en) | Process for producing pharmaceutical compositions containing indol derivatives as active components | |
UA27749C2 (uk) | Заміщені циклопропіламіно-1,3,5-триазини, їх оптичні ізомери, рацемічні суміші чи їх солі приєднання нетоксичних фармацевтично прийнятних кислот, що мають фармакологічну активність, спосіб їх одержання (варіанти) та фармацевтична композиція на їх основі | |
EP0354777A3 (en) | 3-(4-piperidine)-5-(2-sulfonylaminoethyl) indole derivatives | |
RU93004860A (ru) | Гетероциклические соединения, способ их получения, использование и фармацевтическая композиция | |
AU655288B2 (en) | New triazolopyrimidine derivatives which are angiotensin II receptor antagonists; processes for preparing them and pharmaceutical compositions containing them | |
ES8403494A1 (es) | "un procedimiento para la preparacion de derivados de s-adenosilmetionina". | |
HUT50334A (en) | Process for producing arylpiperazinyl-alkilenephenyl-p-heterocycluc compounds, pharmaceutically acceptable acid addition salts thereof and pharmaceutical compositions comprising the compounds as active ingredient | |
ES455691A1 (es) | Procedimiento para la produccion de derivados de piperacina. | |
ES8308833A1 (es) | "un metodo para la preparacion de 3-fenil-1-indanaminas". | |
ZA87343B (en) | 2-benzimidazolylalkylthio(or-sulfinyl or-sulfonyl)derivatives,their preparation and their application as medicinal products | |
HUT44515A (en) | Process for producing isoquinolinol compounds of heart activity increasing, phosphodiesterase iii inhibiting and/or renal vasodilating activity and pharmaceutical composition containing them | |
NZ220539A (en) | 1,4-dihydropyridine derivatives and pharmaceutical compositions | |
ES2001104A6 (es) | Un procedimiento para la preparacion de nuevos derivados sustituidos del acido 1,4-dihidro-3,5-piridindicarboxilico. | |
PT80346A (en) | Process for preparing triazolopyrimidine derivatives | |
ES8502128A1 (es) | Procedimiento para la preparacion de derivados de 6 -metilprednisolona | |
FR2592653A1 (fr) | Derives de chromene, procede d'obtention et compositions pharmaceutiques. | |
EP0207514A3 (en) | 1,4-dihydropyridine derivatives, process for preparing them, pharmaceutical composition and use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |