ES8302093A1 - Un procedimiento para obtener nuevos compuestos de beta-lac-tama - Google Patents
Un procedimiento para obtener nuevos compuestos de beta-lac-tamaInfo
- Publication number
- ES8302093A1 ES8302093A1 ES505886A ES505886A ES8302093A1 ES 8302093 A1 ES8302093 A1 ES 8302093A1 ES 505886 A ES505886 A ES 505886A ES 505886 A ES505886 A ES 505886A ES 8302093 A1 ES8302093 A1 ES 8302093A1
- Authority
- ES
- Spain
- Prior art keywords
- production
- lactam compounds
- medicines containing
- novel beta
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE <021>-LACTAMA Y DE SUS SALES, DE FORMULA (I), EN LA QUE R ES HIDROGENO, HIDROXI O SULFONICO; Y R ES HIDROGENO O BENCILO, SUSTITUIDO O SIN SUSTITUIR. CONSISTE EN CULTIVAR EL MICROORGANISMO <004>STREPTOMYCES SP. OA-6129 (FERM BP11<005>, CAPAZ DE PRODUCIR UN COMPUESTO DE FORMULA (I), EN LA QUE R ES HIDROGENO Y R TIENE EL MISMO SIGNIFICADO ANTERIOR, EN UN MEDIO DE CULTIVO NUTRIENTE, EN CONDICIONES AEROBIAS, A UN PH ENTRE 4 Y 9 Y A UNA TEMPERATURA COMPRENDIDA ENTRE 20<025>C Y 40<025>C; SEGUIDO DE LA RECUPERACION DEL COMPUESTO OBTENIDO; Y, SI ES NECESARIO, TRANSFORMARLO EN SU ESTER BENCILICO O EN SU SAL. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIMICROBIANOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55135829A JPS5762280A (en) | 1980-10-01 | 1980-10-01 | Novel antibiotic oa-6129a and its preparation |
JP55144507A JPS5770890A (en) | 1980-10-17 | 1980-10-17 | Novel antibiotic oa-6129b and its preparation |
JP55170864A JPS5795987A (en) | 1980-12-05 | 1980-12-05 | Novel antibiotic oa-6129c and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8302093A1 true ES8302093A1 (es) | 1983-01-01 |
ES505886A0 ES505886A0 (es) | 1983-01-01 |
Family
ID=27317159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES505886A Granted ES505886A0 (es) | 1980-10-01 | 1981-09-30 | Un procedimiento para obtener nuevos compuestos de beta-lac-tama |
Country Status (6)
Country | Link |
---|---|
US (1) | US4426390A (es) |
EP (1) | EP0048999B1 (es) |
KR (1) | KR850000577B1 (es) |
CA (1) | CA1182413A (es) |
DE (1) | DE3171598D1 (es) |
ES (1) | ES505886A0 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3277622D1 (en) * | 1981-07-01 | 1987-12-17 | Sanraku Inc | Novel antibiotics and process for production thereof |
JPS5857392A (ja) * | 1981-10-02 | 1983-04-05 | Sanraku Inc | 新規な抗生物質oa−6129のリン酸エステル |
KR840003255A (ko) * | 1982-01-28 | 1984-08-20 | 스즈끼 시즈오 | 항생물질 oa-6129a,b1,b2의 유도체 및 그 제법 |
US5882900A (en) * | 1992-09-10 | 1999-03-16 | Gruppo Lepetit S.P.A. | Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3950357A (en) | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
CH632508A5 (de) * | 1975-11-21 | 1982-10-15 | Merck & Co Inc | Verfahren zur herstellung von neuen estern des n-acylierten thienamycins. |
AU6377980A (en) * | 1979-10-29 | 1981-05-07 | Beecham Group Limited | 1-azabicyclo(3,2,0)hept-2-ene derivatives |
-
1981
- 1981-09-29 US US06/306,931 patent/US4426390A/en not_active Expired - Fee Related
- 1981-09-30 CA CA000386958A patent/CA1182413A/en not_active Expired
- 1981-09-30 ES ES505886A patent/ES505886A0/es active Granted
- 1981-10-01 EP EP81107819A patent/EP0048999B1/en not_active Expired
- 1981-10-01 DE DE8181107819T patent/DE3171598D1/de not_active Expired
- 1981-10-02 KR KR1019810003723A patent/KR850000577B1/ko active
Also Published As
Publication number | Publication date |
---|---|
DE3171598D1 (en) | 1985-09-05 |
EP0048999B1 (en) | 1985-07-31 |
US4426390A (en) | 1984-01-17 |
CA1182413A (en) | 1985-02-12 |
ES505886A0 (es) | 1983-01-01 |
KR850000577B1 (ko) | 1985-04-29 |
EP0048999A1 (en) | 1982-04-07 |
KR830007840A (ko) | 1983-11-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960603 |