ES469568A1 - Procedimiento para la obtencion de compuestos de acido 2-pe-nem-3-carboxilicos - Google Patents

Procedimiento para la obtencion de compuestos de acido 2-pe-nem-3-carboxilicos

Info

Publication number
ES469568A1
ES469568A1 ES469568A ES469568A ES469568A1 ES 469568 A1 ES469568 A1 ES 469568A1 ES 469568 A ES469568 A ES 469568A ES 469568 A ES469568 A ES 469568A ES 469568 A1 ES469568 A1 ES 469568A1
Authority
ES
Spain
Prior art keywords
compounds
thia
beta
processes
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469568A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES469568A1 publication Critical patent/ES469568A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Abstract

Procedimiento para la obtención de compuestos de ácido 2-penem-3carboxílicos de fórmula **fórmula ** donde R1 significa hidrógeno, un resto orgánico enlazado a través de un átomo de carbono con el átomo de carbono del anillo, o un grupo mercapto eterado y R2 significa hidroxi o un Resto Ra2 junto con la agrupación carbonilo -C(=O)- forma un grupo carboxilo protegido, los 1-óxidos de los mismos, así como las sales de tales compuestos con grupos formadores de sal.
ES469568A 1977-05-09 1978-05-08 Procedimiento para la obtencion de compuestos de acido 2-pe-nem-3-carboxilicos Expired ES469568A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77306A LU77306A1 (es) 1977-05-09 1977-05-09

Publications (1)

Publication Number Publication Date
ES469568A1 true ES469568A1 (es) 1980-01-01

Family

ID=19728568

Family Applications (1)

Application Number Title Priority Date Filing Date
ES469568A Expired ES469568A1 (es) 1977-05-09 1978-05-08 Procedimiento para la obtencion de compuestos de acido 2-pe-nem-3-carboxilicos

Country Status (13)

Country Link
US (5) US4331676A (es)
JP (1) JPS53137951A (es)
AU (1) AU527917B2 (es)
BE (1) BE866845A (es)
CH (1) CH646173A5 (es)
DE (1) DE2819655A1 (es)
DK (1) DK200578A (es)
ES (1) ES469568A1 (es)
FR (8) FR2405949A1 (es)
GB (4) GB1604752A (es)
LU (1) LU77306A1 (es)
NL (1) NL7804974A (es)
SE (2) SE443980B (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055573A (en) * 1976-11-19 1991-10-08 Merck & Co., Inc. Process for preparing 1-carba-2-penem-3-carboxylic acid
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IN149747B (es) * 1977-06-07 1982-04-03 Pfizer
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0003415A3 (en) * 1978-01-20 1979-08-22 Glaxo Group Limited Beta-lactam compounds, processes for their preparation,compositions containing them and intermediates of use in their preparation
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
EP0003892A1 (en) * 1978-02-16 1979-09-05 Glaxo Group Limited Beta-lactam compounds, processes for their production, compositions containing them and intermediates of use in their preparation
EP0010358A1 (en) * 1978-09-20 1980-04-30 Glaxo Group Limited Beta-lactam compounds, processes for their preparation, compositions containing them, intermediates of use in their preparation and methods for the production thereof
US4290948A (en) 1978-11-22 1981-09-22 Beecham Group Limited Process for their preparation of β-lactam antibacterial agents
AT365594B (de) * 1978-11-24 1982-01-25 Erba Farmitalia Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes
ATE3041T1 (de) * 1979-01-10 1983-04-15 Schering Corporation 2-penem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
GR73623B (es) * 1979-02-24 1984-03-26 Erba Farmitalia
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4683226A (en) * 1979-08-01 1987-07-28 Schering Corporation 6-hydroxyalkyl-2-(substituted-thio)penem-3-carboxylic acids
US4406834A (en) 1979-09-21 1983-09-27 Bristol-Myers Company 2,6 Disubstituted penems and intermediates therefor
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
EP0031509B1 (en) * 1979-12-20 1984-10-24 Hoechst Uk Limited Penem derivatives
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS56142282A (en) * 1980-03-10 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
JPS56142283A (en) * 1980-03-17 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
ATE21105T1 (de) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
ES8305366A1 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".
EP0069378B1 (en) * 1981-07-08 1987-01-07 Hoechst Uk Limited Antibacterial penem derivatives
JPS58116487A (ja) * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
JPS5946289A (ja) * 1982-09-08 1984-03-15 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
JPS60243064A (ja) * 1984-05-17 1985-12-03 Taiho Yakuhin Kogyo Kk アゼチジノンジスルフイド誘導体
EP0379281A3 (en) * 1989-01-19 1991-03-20 Cosmopolitan Textile Company Limited Web inspecting method and apparatus
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
JPH08502752A (ja) * 1992-10-27 1996-03-26 メルク エンド カンパニー インコーポレーテッド 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
AU2003274518A1 (en) * 2002-11-01 2004-05-25 Orchid Chemicals And Pharmaceuticals Ltd A process for the preparation of benzyl 2-oxo-4- (heteroaryl) dithio-alpha-isoprenyl-1- azetidineazetate derivatives
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
JP2015518854A (ja) * 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
US11905177B2 (en) * 2018-05-07 2024-02-20 Covestro Intellectual Property Gmbh & Co. Kg Storage medium and method for separating, storing and transporting chlorine from chlorine-containing gases
CN114720591B (zh) * 2022-03-22 2022-12-30 北京安胜瑞力科技有限公司 一种工业废水中dmac的定量分析方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE648188A (es) 1963-05-29 1964-09-16
BE755940A (fr) * 1969-09-09 1971-03-09 Hoechst Ag Azetidinones-2 portant des substituants en position 4 et leur preparation
GB1368074A (en) * 1971-02-04 1974-09-25 Beecham Group Ltd Substituted beta-lactams and their preparation
FR2143211B1 (es) * 1971-06-24 1975-10-31 Fujisawa Pharmaceutical Co
JPS4854056A (es) * 1971-11-12 1973-07-30
US4070477A (en) * 1975-12-08 1978-01-24 Ciba-Geigy Corporation 2-Penem compounds
IN149747B (es) * 1977-06-07 1982-04-03 Pfizer
EP0000636A1 (en) * 1977-07-13 1979-02-07 Glaxo Group Limited Penem compounds, processes for their preparation, their use in pharmaceutical compositions and azetidinones used in their preparation
GB2005246A (en) * 1977-07-13 1979-04-19 Glaxo Group Ltd beta -Lactam compounds and processes for their preparation
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4169833A (en) * 1977-12-14 1979-10-02 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4192801A (en) * 1978-04-27 1980-03-11 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates

Also Published As

Publication number Publication date
FR2405950A1 (fr) 1979-05-11
US4447360A (en) 1984-05-08
FR2405949A1 (fr) 1979-05-11
FR2422637B1 (es) 1982-04-23
US4524028A (en) 1985-06-18
FR2405946B1 (es) 1983-09-30
FR2405945A1 (fr) 1979-05-11
GB1604753A (en) 1981-12-16
LU77306A1 (es) 1979-01-18
GB1604751A (en) 1981-12-16
FR2411179A1 (fr) 1979-07-06
US4515717A (en) 1985-05-07
AU3588478A (en) 1979-11-15
SE8305299L (sv) 1983-09-29
FR2405950B1 (es) 1981-07-31
FR2405945B1 (es) 1982-04-09
FR2405946A1 (fr) 1979-05-11
FR2405955A1 (fr) 1979-05-11
SE7805217L (sv) 1978-11-10
DK200578A (da) 1978-11-10
GB1604752A (en) 1981-12-16
SE443980B (sv) 1986-03-17
SE8305299D0 (sv) 1983-09-29
FR2411179B1 (es) 1982-04-23
NL7804974A (nl) 1978-11-13
FR2405949B1 (es) 1980-10-24
JPS53137951A (en) 1978-12-01
BE866845A (fr) 1978-11-09
AU527917B2 (en) 1983-03-31
CH646173A5 (de) 1984-11-15
FR2405955B1 (es) 1981-07-31
US4518533A (en) 1985-05-21
US4331676A (en) 1982-05-25
GB1604754A (en) 1981-12-16
FR2405934B1 (es) 1980-09-05
DE2819655A1 (de) 1978-11-23
FR2405934A1 (fr) 1979-05-11
FR2422637A1 (fr) 1979-11-09

Similar Documents

Publication Publication Date Title
ES469568A1 (es) Procedimiento para la obtencion de compuestos de acido 2-pe-nem-3-carboxilicos
ES477336A1 (es) Procedimiento para la obtencion de compuestos del acido 2- penem-2-carboxilico.
DE3069408D1 (en) 5-oxo- and 5-thioxoproline derivatives, process for their production and pharmaceutical compositions containing them
ES452361A1 (es) Un procedimiento para la preparacion de nuevos derivados delacido clavulanico.
EP0001643A3 (en) Aminoglycoside derivatives, process for their manufacture, pharmaceutical compositions and carboxylic acids
FI820061L (fi) Nya karboxylsyraamider deras framstaellning och deras anvaendning saosom laekemedel
HUT48307A (en) Process for production of herbicides containing as active substance cyclic internal anhydrid either its free acid form or its salts and process for the production of the activ substances
ES444948A1 (es) Un procedimiento para la separacion de impurezas contaminan-tes del acido clavulanico.
ES453161A1 (es) Un procedimiento de preparacion de espiro (1,3-dioxolan-4,3)quinuclidinas.
ES453690A1 (es) Procedimiento para la preparacion de compuestos heterocicli-cos.
ES8100303A1 (es) Procedimiento para la obtencion de compuestos de acido aminotiazolacetamino-3-cefem-4-carboxilico
ES454997A1 (es) Procedimiento para preparar nuevos derivados del acido 7- amino-tiazolil-acetamido-cefalosporanico.
DE3267188D1 (en) Hydroxybenzylamino-aryl compounds, process for preparing and pharmaceutical compositions containing the same
SE7609909L (sv) Nya penicilliner och forfarande for framstellning derav
GB1073828A (en) O-desacetyl-o-carbamoyl-7-acylamino-cephalosporanic acids
ES8102139A1 (es) Un procedimiento para la preparacion de antibioticos de ce- falosporina
ES8601183A1 (es) Procedimiento para preparar derivados de acidos 1-oxido-1, 2-ditiolano-carboxilicos
ES8407053A1 (es) Un procedimiento para la preparacion de nuevos derivados de penem-2-tiosustituidos.
ATE32724T1 (de) Cephalosporinverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
IE800355L (en) Producing cepham compounds.
ES482194A1 (es) Procedimiento para la obtencion de compuestos de acido 7- aminotiazolilacetamido-3-cefem-4-carboxilico.
ES8101646A1 (es) Un procedimiento para producir un compuesto opticamente ac- tivo
ES481602A1 (es) Un procedimiento para la preparacion de derivados de la hi- dantoina.
ES8302093A1 (es) Un procedimiento para obtener nuevos compuestos de beta-lac-tama
ES481603A1 (es) Un procedimiento para la preparacion de un derivado de la hidantoina.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405