GB1368074A - Substituted beta-lactams and their preparation - Google Patents

Substituted beta-lactams and their preparation

Info

Publication number
GB1368074A
GB1368074A GB388371A GB388371A GB1368074A GB 1368074 A GB1368074 A GB 1368074A GB 388371 A GB388371 A GB 388371A GB 388371 A GB388371 A GB 388371A GB 1368074 A GB1368074 A GB 1368074A
Authority
GB
United Kingdom
Prior art keywords
group
hydrogen atom
acyl
hydrogen
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB388371A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB388371A priority Critical patent/GB1368074A/en
Priority to ZA720166A priority patent/ZA72166B/en
Priority to FR7202006A priority patent/FR2124251A1/fr
Priority to AU38372/72A priority patent/AU3837272A/en
Priority to ES399347A priority patent/ES399347A1/en
Priority to NL7201386A priority patent/NL7201386A/xx
Priority to DE19722205123 priority patent/DE2205123A1/en
Priority to BE779016A priority patent/BE779016A/en
Priority to ES427900A priority patent/ES427900A1/en
Priority to ES427901A priority patent/ES427901A1/en
Publication of GB1368074A publication Critical patent/GB1368074A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1368074 Azetidin - 2 - ones BEECHAM GROUP Ltd 7 Jan 1972 [4 Feb 1971] 3883/71 Heading C2C Novel azetidin-2-ones of the general formula wherein X is a hydrogen or halogen atom or an optionally substituted amino group; Y is a hydrogen atom or, when X is a hydrogen or halogen atom, a halogen atom; R<SP>3</SP> is a hydrogen atom or a -CR<SP>4</SP> = C(CH 3 ) 2 group, in which R<SP>4</SP> is -COOH or a salt, ester, thioester or amide group derived from it; and A is (i) a group, in which R<SP>1</SP> is a hydrogen atom or an alkyl, alkenyl, alkynyl or aryl group and R<SP>2</SP> is a hydrogen atom or carboxylic acyl group, or (ii) a -SO-CH 2 Z group, in which Z is as R<SP>1</SP> above, are prepared (a) when A is (i) above in which R<SP>2</SP> is an acyl group or (ii) above, by reaction of the corresponding compound in which A is a -SCH 2 Z group with a compound of the formula Pb(O-acyl) 4 ; (b) when A is (ii) above, by oxidation of the corresponding compound in which A is a -SCH 2 Z group; (c) when A is (i) above in which R<SP>2</SP> is an acyl group, by reaction of the correspondingly compound in which A is (ii) above with an acid anhydride; and (d) when A is (i) above in which R<SP>2</SP> is a hydrogen atom, by mild hydrolysis of the corresponding compound in which R<SP>2</SP> is an acyl group. Reference has been directed by the Comptroller to Specification 1,315,995.
GB388371A 1971-02-04 1971-02-04 Substituted beta-lactams and their preparation Expired GB1368074A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB388371A GB1368074A (en) 1971-02-04 1971-02-04 Substituted beta-lactams and their preparation
ZA720166A ZA72166B (en) 1971-02-04 1972-01-11 Substituted beta-lactams and their preparation
FR7202006A FR2124251A1 (en) 1971-02-04 1972-01-21
AU38372/72A AU3837272A (en) 1971-02-04 1972-01-26 Penicillins
ES399347A ES399347A1 (en) 1971-02-04 1972-01-31 Substituted beta-lactams and their preparation
NL7201386A NL7201386A (en) 1971-02-04 1972-02-02
DE19722205123 DE2205123A1 (en) 1971-02-04 1972-02-03 2-Oxo-azetidines and process for their preparation
BE779016A BE779016A (en) 1971-02-04 1972-02-04 PENICILLINS
ES427900A ES427900A1 (en) 1971-02-04 1974-07-01 Substituted beta-lactams and their preparation
ES427901A ES427901A1 (en) 1971-02-04 1974-07-01 Substituted beta-lactams and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB388371A GB1368074A (en) 1971-02-04 1971-02-04 Substituted beta-lactams and their preparation

Publications (1)

Publication Number Publication Date
GB1368074A true GB1368074A (en) 1974-09-25

Family

ID=9766672

Family Applications (1)

Application Number Title Priority Date Filing Date
GB388371A Expired GB1368074A (en) 1971-02-04 1971-02-04 Substituted beta-lactams and their preparation

Country Status (8)

Country Link
AU (1) AU3837272A (en)
BE (1) BE779016A (en)
DE (1) DE2205123A1 (en)
ES (3) ES399347A1 (en)
FR (1) FR2124251A1 (en)
GB (1) GB1368074A (en)
NL (1) NL7201386A (en)
ZA (1) ZA72166B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000636A1 (en) * 1977-07-13 1979-02-07 Glaxo Group Limited Penem compounds, processes for their preparation, their use in pharmaceutical compositions and azetidinones used in their preparation
EP0020883A1 (en) * 1979-04-03 1981-01-07 Shionogi & Co., Ltd. A process for preparing 3-beta-amino-4-beta-substituted 2-azetidinones and 3-(2,2-dihalogenovinyl)-imino-4-beta-substituted 2-azetidinone and 3-beta-(2,2-dihalogenovinyl)-amino-4-beta-substituted 2-azetidinone intermediates
US4515717A (en) * 1977-05-09 1985-05-07 Ciba Geigy Corporation Thia-aza compounds with a β-lactam ring
EP0232966A1 (en) * 1986-01-17 1987-08-19 Beecham Group Plc Process for the preparation of penem compounds and intermediates for this preparation

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042026B1 (en) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-disubstituted azetidin-2-on compounds and process for their preparation
DE3069597D1 (en) * 1979-08-01 1984-12-13 Ciba Geigy Ag 3-substituted bicyclic azetidinone derivatives, process for their preparation, and intermediates as well as their preparation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515717A (en) * 1977-05-09 1985-05-07 Ciba Geigy Corporation Thia-aza compounds with a β-lactam ring
EP0000636A1 (en) * 1977-07-13 1979-02-07 Glaxo Group Limited Penem compounds, processes for their preparation, their use in pharmaceutical compositions and azetidinones used in their preparation
EP0020883A1 (en) * 1979-04-03 1981-01-07 Shionogi & Co., Ltd. A process for preparing 3-beta-amino-4-beta-substituted 2-azetidinones and 3-(2,2-dihalogenovinyl)-imino-4-beta-substituted 2-azetidinone and 3-beta-(2,2-dihalogenovinyl)-amino-4-beta-substituted 2-azetidinone intermediates
EP0232966A1 (en) * 1986-01-17 1987-08-19 Beecham Group Plc Process for the preparation of penem compounds and intermediates for this preparation

Also Published As

Publication number Publication date
ES399347A1 (en) 1975-06-01
BE779016A (en) 1972-08-04
ES427900A1 (en) 1976-12-16
DE2205123A1 (en) 1972-08-10
ZA72166B (en) 1972-09-27
NL7201386A (en) 1972-08-08
AU3837272A (en) 1973-08-02
FR2124251A1 (en) 1972-09-22
ES427901A1 (en) 1976-12-16

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees