ES477336A1 - Procedimiento para la obtencion de compuestos del acido 2- penem-2-carboxilico. - Google Patents

Procedimiento para la obtencion de compuestos del acido 2- penem-2-carboxilico.

Info

Publication number
ES477336A1
ES477336A1 ES477336A ES477336A ES477336A1 ES 477336 A1 ES477336 A1 ES 477336A1 ES 477336 A ES477336 A ES 477336A ES 477336 A ES477336 A ES 477336A ES 477336 A1 ES477336 A1 ES 477336A1
Authority
ES
Spain
Prior art keywords
compounds
carbon atom
aza
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES477336A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES477336A1 publication Critical patent/ES477336A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Abstract

Procedimiento para la obtención de compuestos del ácido 2- penem-3-carboxílico de fórmula **(Fórmula)** donde Ra significa un resto orgánico unido a través de un átomo de carbono con el átomo de carbono del anillo, un grupo hidroxi o mercapto, libre, eterado o esterificado, o halógeno, R1 significa hidrógeno, un resto orgánico enlazado a través de un átomo de carbono con el átomo de carbono del anillo, o un grupo mercapto eterado y R2 significa hidroxi o un resto R2A que forma junto con la agrupación carbonilo -C(=O)- un grupo carboxilo protegido, así como las sales de tales compuestos con grupos formadores de sal.
ES477336A 1978-02-02 1979-01-31 Procedimiento para la obtencion de compuestos del acido 2- penem-2-carboxilico. Expired ES477336A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH114078 1978-02-02

Publications (1)

Publication Number Publication Date
ES477336A1 true ES477336A1 (es) 1979-07-01

Family

ID=4203421

Family Applications (1)

Application Number Title Priority Date Filing Date
ES477336A Expired ES477336A1 (es) 1978-02-02 1979-01-31 Procedimiento para la obtencion de compuestos del acido 2- penem-2-carboxilico.

Country Status (23)

Country Link
US (2) US4692442A (es)
EP (2) EP0042026B1 (es)
JP (3) JPS54119486A (es)
AR (1) AR228236A1 (es)
AT (1) AT362876B (es)
AU (1) AU519317B2 (es)
CA (1) CA1340273C (es)
CS (1) CS222279B2 (es)
DD (1) DD142342A5 (es)
DK (1) DK160099C (es)
ES (1) ES477336A1 (es)
FI (1) FI73219C (es)
GB (1) GB2013674A (es)
GR (1) GR72911B (es)
HU (1) HU182017B (es)
IE (1) IE48776B1 (es)
IL (1) IL56557A (es)
NO (1) NO158679C (es)
NZ (1) NZ189530A (es)
PL (1) PL122371B1 (es)
PT (1) PT69166A (es)
SU (1) SU925252A3 (es)
ZA (1) ZA79433B (es)

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US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
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US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
EP0061205B1 (en) * 1979-01-10 1986-03-12 Schering Corporation 2-penem compounds; a method for their preparation and pharmaceutical compositions comprising them
NL192265C (nl) * 1979-02-24 1997-04-03 Erba Carlo Spa Penemcarbonzuur-verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
JPS55153789A (en) * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4443463A (en) * 1979-11-05 1984-04-17 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(hydroxyalkylthio)-penem-3-carboxylates
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JPS56142283A (en) * 1980-03-17 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
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DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
ES502828A0 (es) * 1980-06-06 1982-11-01 Sankyo Co Un procedimiento para la preparacion de derivados del acido penen-3-carboxilico.
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JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
CA1190236A (en) * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
US4411906A (en) * 1981-11-25 1983-10-25 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
SU1389680A3 (ru) * 1981-12-11 1988-04-15 Фармиталия Карло Эрба С.П.А. (Фирма) Способ получени оптически активных пенемов или их солей с щелочными металлами
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
JPS591464A (ja) * 1982-06-26 1984-01-06 Sankyo Co Ltd β−ラクタム化合物及びその製法
FI77662C (fi) * 1982-07-08 1989-04-10 Hoechst Uk Ltd Foerfarande foer framstaellning av nya antibakteriella penemderivat.
EP0112283B1 (de) * 1982-11-16 1987-08-12 Ciba-Geigy Ag Heterocyclylthioverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
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DE3366926D1 (en) * 1982-11-16 1986-11-20 Schering Corp Penems, pharmaceutical compositions containing them, process for preparing them
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EP0109362A1 (de) * 1982-11-16 1984-05-23 Ciba-Geigy Ag Heterocyclylverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
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CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
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ATE159021T1 (de) * 1986-01-17 1997-10-15 Beecham Group Plc Verfahren zur herstellung von penem derivaten und zwischenprodukte zu dieser herstellung
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Also Published As

Publication number Publication date
US4692442A (en) 1987-09-08
GR72911B (es) 1984-01-05
IE48776B1 (en) 1985-05-15
NO158679C (no) 1988-10-19
ZA79433B (en) 1980-02-27
FI73219C (fi) 1987-09-10
DK43279A (da) 1979-08-03
DK160099C (da) 1991-06-24
NZ189530A (en) 1982-02-23
AU519317B2 (en) 1981-11-26
PT69166A (de) 1979-03-01
PL122371B1 (en) 1982-07-31
JPH01110668A (ja) 1989-04-27
GB2013674A (en) 1979-08-15
NO790332L (no) 1979-08-03
IL56557A (en) 1982-01-31
JPS54119486A (en) 1979-09-17
ATA74579A (de) 1980-11-15
FI73219B (fi) 1987-05-29
CA1340273C (en) 1998-12-15
AR228236A1 (es) 1983-02-15
JPH0314037B2 (es) 1991-02-25
EP0042026A1 (de) 1981-12-23
CS222279B2 (en) 1983-06-24
HU182017B (en) 1983-12-28
PL213133A1 (es) 1980-03-10
EP0003960B1 (de) 1983-06-29
AU4384379A (en) 1979-08-09
JPH0329789B2 (es) 1991-04-25
FI790321A (fi) 1979-08-03
JPH045677B2 (es) 1992-02-03
SU925252A3 (ru) 1982-04-30
US4952690A (en) 1990-08-28
JPS62129264A (ja) 1987-06-11
DK160099B (da) 1991-01-28
EP0042026B1 (de) 1986-01-08
IL56557A0 (en) 1979-03-12
DD142342A5 (de) 1980-06-18
IE790191L (en) 1979-08-02
NO158679B (no) 1988-07-11
EP0003960A1 (de) 1979-09-19
AT362876B (de) 1981-06-25

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