CS222279B2 - Method of making the derivative of the 2-penem-3-carboxyle acid - Google Patents

Method of making the derivative of the 2-penem-3-carboxyle acid

Info

Publication number
CS222279B2
CS222279B2 CS79755A CS75579A CS222279B2 CS 222279 B2 CS222279 B2 CS 222279B2 CS 79755 A CS79755 A CS 79755A CS 75579 A CS75579 A CS 75579A CS 222279 B2 CS222279 B2 CS 222279B2
Authority
CS
Czechoslovakia
Prior art keywords
carboxyle
penem
derivative
acid
making
Prior art date
Application number
CS79755A
Other languages
English (en)
Inventor
Jacques Gosteli
Ivan Ernest
Marc Lang
Robert B Woodward
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CS222279B2 publication Critical patent/CS222279B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS79755A 1978-02-02 1979-02-02 Method of making the derivative of the 2-penem-3-carboxyle acid CS222279B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH114078 1978-02-02

Publications (1)

Publication Number Publication Date
CS222279B2 true CS222279B2 (en) 1983-06-24

Family

ID=4203421

Family Applications (1)

Application Number Title Priority Date Filing Date
CS79755A CS222279B2 (en) 1978-02-02 1979-02-02 Method of making the derivative of the 2-penem-3-carboxyle acid

Country Status (23)

Country Link
US (2) US4692442A (cs)
EP (2) EP0042026B1 (cs)
JP (3) JPS54119486A (cs)
AR (1) AR228236A1 (cs)
AT (1) AT362876B (cs)
AU (1) AU519317B2 (cs)
CA (1) CA1340273C (cs)
CS (1) CS222279B2 (cs)
DD (1) DD142342A5 (cs)
DK (1) DK160099C (cs)
ES (1) ES477336A1 (cs)
FI (1) FI73219C (cs)
GB (1) GB2013674A (cs)
GR (1) GR72911B (cs)
HU (1) HU182017B (cs)
IE (1) IE48776B1 (cs)
IL (1) IL56557A (cs)
NO (1) NO158679C (cs)
NZ (1) NZ189530A (cs)
PL (1) PL122371B1 (cs)
PT (1) PT69166A (cs)
SU (1) SU925252A3 (cs)
ZA (1) ZA79433B (cs)

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US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
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NL192265C (nl) * 1979-02-24 1997-04-03 Erba Carlo Spa Penemcarbonzuur-verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
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US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
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JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
CA1190236A (en) * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
US4411906A (en) * 1981-11-25 1983-10-25 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
US4508649A (en) * 1981-12-11 1985-04-02 Farmitalia Carlo Erba Process for preparing optically active penems
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
JPS591464A (ja) * 1982-06-26 1984-01-06 Sankyo Co Ltd β−ラクタム化合物及びその製法
IL69174A0 (en) * 1982-07-08 1983-11-30 Hoechst Uk Ltd Antibacterial penem derivatives
US4540579A (en) * 1982-11-16 1985-09-10 Schering Corporation 2-[(R) Amino acid alkyl]penems
DE3372968D1 (en) * 1982-11-16 1987-09-17 Ciba Geigy Ag Heterocyclyl-thio compounds, process for their preparation, pharmaceutical compositions containing them and their use
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US4435413A (en) 1983-01-28 1984-03-06 Schering Corporation (5R-6S,8R)-6-(1-Hydroxyethyl)-2-(2-glycylaminoethylthio)-penem-3-carboxylic acid
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EP0125207A1 (de) * 1983-05-06 1984-11-14 Ciba-Geigy Ag 2-Tetrazolylpropyl-2-penem-Verbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4619783A (en) * 1983-06-10 1986-10-28 Pfizer Inc. Process and intermediates for the preparation of penem derivatives
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
US4554103A (en) * 1983-07-14 1985-11-19 Schering Corporation Preparation of 4-acyloxyazetidinones from acyl nitrates and penams
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4584133A (en) * 1983-11-07 1986-04-22 Schering Corporation Process for the production of penems
US4587241A (en) * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
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US4711886A (en) * 1984-07-02 1987-12-08 Merck & Co., Inc. β-lactam derivatives as anti-inflammatory and antidegenerative agents
JPS62501556A (ja) * 1984-07-13 1987-06-25 メルシャン株式会社 新規２↓−オキソアゼチジン類、その製造方法および応用
US4617300A (en) * 1984-09-21 1986-10-14 Schering Corporation 2(N-heterocyclyl) penems
EP0181831B1 (de) * 1984-10-01 1993-08-25 Ciba-Geigy Ag Verfahren zur Herstellung von optisch aktiven Acyloxyazetidinonen
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0199675A1 (de) * 1985-04-17 1986-10-29 Ciba-Geigy Ag Heterocyclyl-penem-Verbindungen
DE3752124T2 (de) * 1986-01-17 1998-03-26 Beecham Group Plc Verfahren zur Herstellung von Penem Derivaten und Zwischenprodukte zu dieser Herstellung
US4806637A (en) * 1986-03-17 1989-02-21 Schering Corporation 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates
US4826832A (en) * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
JP2526046B2 (ja) * 1986-12-26 1996-08-21 サントリー株式会社 ペネム誘導体、その製造法およびその用途
ES2058328T3 (es) * 1987-02-11 1994-11-01 Ciba Geigy Ag Acidos beta-lactama carboxilicos biciclicos.
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US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
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US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
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JPH08502752A (ja) * 1992-10-27 1996-03-26 メルク エンド カンパニー インコーポレーテッド 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
DE69629152T2 (de) * 1995-02-17 2004-07-08 Daiichi Suntory Pharma Co., Ltd. Penem-derivate und sie enthaltende anti-mikrobische mittel
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US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
DE3069597D1 (en) * 1979-08-01 1984-12-13 Ciba Geigy Ag 3-substituted bicyclic azetidinone derivatives, process for their preparation, and intermediates as well as their preparation
DE3372968D1 (en) * 1982-11-16 1987-09-17 Ciba Geigy Ag Heterocyclyl-thio compounds, process for their preparation, pharmaceutical compositions containing them and their use
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Also Published As

Publication number Publication date
DK43279A (da) 1979-08-03
NO158679C (no) 1988-10-19
ES477336A1 (es) 1979-07-01
IL56557A0 (en) 1979-03-12
GR72911B (cs) 1984-01-05
PL213133A1 (cs) 1980-03-10
ZA79433B (en) 1980-02-27
NZ189530A (en) 1982-02-23
JPH0329789B2 (cs) 1991-04-25
IL56557A (en) 1982-01-31
JPS54119486A (en) 1979-09-17
HU182017B (en) 1983-12-28
EP0042026B1 (de) 1986-01-08
ATA74579A (de) 1980-11-15
DK160099C (da) 1991-06-24
PL122371B1 (en) 1982-07-31
JPS62129264A (ja) 1987-06-11
DD142342A5 (de) 1980-06-18
AT362876B (de) 1981-06-25
US4692442A (en) 1987-09-08
FI73219B (fi) 1987-05-29
EP0003960B1 (de) 1983-06-29
FI73219C (fi) 1987-09-10
IE48776B1 (en) 1985-05-15
JPH045677B2 (cs) 1992-02-03
JPH0314037B2 (cs) 1991-02-25
US4952690A (en) 1990-08-28
EP0003960A1 (de) 1979-09-19
DK160099B (da) 1991-01-28
JPH01110668A (ja) 1989-04-27
IE790191L (en) 1979-08-02
FI790321A7 (fi) 1979-08-03
SU925252A3 (ru) 1982-04-30
GB2013674A (en) 1979-08-15
NO158679B (no) 1988-07-11
PT69166A (de) 1979-03-01
NO790332L (no) 1979-08-03
AU519317B2 (en) 1981-11-26
CA1340273C (en) 1998-12-15
AU4384379A (en) 1979-08-09
EP0042026A1 (de) 1981-12-23
AR228236A1 (es) 1983-02-15

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