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Method of making the derivative of the 2-penem-3-carboxyle acid

Classifications

C07D499/88 Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
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CS222279B2

Czechoslovakia

Find Prior Art Similar
Other languages
English
Inventor
Jacques Gosteli
Ivan Ernest
Marc Lang
Robert B Woodward
Worldwide applications
1979 EP EP GB ES GR CA IL FI SU AT ZA AU IE DK PL PT HU NZ NO AR JP CS DD 1980 US 1986 JP 1988 JP 1989 US
Application CS79755A events
1979-02-02
Application filed by Ciba Geigy Ag
1983-06-24
Publication of CS222279B2
Info
Patent citations (13)
Cited by (90)
Similar documents
Priority and Related Applications
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Patent Citations (13)

Publication number Priority date Publication date Assignee Title
Family To Family Citations
GB1368074A * 1971-02-04 1974-09-25 Beecham Group Ltd Substituted beta-lactams and their preparation
US4364865A * 1975-12-08 1982-12-21 Ciba-Geigy Corporation Bicyclic unsaturated thia-aza compounds and 4-acylthio azetidinone intermediates
US4543257A * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
US4500457A * 1977-05-09 1985-02-19 Ciba-Geigy Corporation Process for preparing thia-aza compounds with a beta-lactam ring
LU77306A1 * 1977-05-09 1979-01-18
US4168314A * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4123539A * 1977-12-29 1978-10-31 Merck & Co., Inc. 6-Ethylpenicillanic acid
US4272437A * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
EP0023887B1 * 1979-08-01 1984-11-07 Ciba-Geigy Ag 3-Substituierte bicyclische Azetidinonderivate, Verfahren zu ihrer Herstellung und Zwischenprodukte, sowie deren Herstellung
EP0112283B1 * 1982-11-16 1987-08-12 Ciba-Geigy Ag Heterocyclylthioverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
EP0126709B1 * 1983-03-28 1991-04-03 Ciba-Geigy Ag Verfahren zur Herstellung von optisch aktiven Azetidinonen
US4656165A * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4826832A * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
* Cited by examiner, † Cited by third party

Cited By (90)

Publication number Priority date Publication date Assignee Title
Family To Family Citations
US5071843A * 1978-07-24 1991-12-10 Merck & Co., Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
US4880793A * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
JPS5625110A * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
US4282150A 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
EP0061205B1 * 1979-01-10 1986-03-12 Schering Corporation 2-penem compounds; a method for their preparation and pharmaceutical compositions comprising them
IL59081A0 * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
AU535080B2 * 1979-02-24 1984-03-01 Farmitalia Carlo Erba S.R.L. Penicillins
JPS55153789A * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
US4378314A 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4374065A 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4443463A * 1979-11-05 1984-04-17 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(hydroxyalkylthio)-penem-3-carboxylates
DE3169939D1 * 1980-02-28 1985-05-23 Schering Corp 2-penem compounds, pharmaceutical compositions containing them and methods for their preparation
JPS56142283A * 1980-03-17 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
SE8101464L * 1980-03-10 1981-09-11 Sankyo Co 2-penem-3-karboxylsyraderivat, deras framstellning och anvendning
DE3176517D1 * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
ES8300769A1 * 1980-06-06 1982-11-01 Sankyo Co Un procedimiento para la preparacion de derivados del acido penen-3-carboxilico.
DE3121510A1 * 1980-07-04 1982-06-16 Farmitalia Carlo Erba S.p.A., 20159 Milano 6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
DE3167198D1 * 1980-08-16 1984-12-20 Beecham Group Plc Process for the preparation of 2-thio penem derivatives and intermediates therefor
EP0051813B1 * 1980-11-06 1986-07-30 Hoechst Uk Limited 7-oxo-4-thia-1-aza(3,2,0)heptane and 7-oxo-4-thia-1-aza(3,2,0)hept-2-ene derivatives
US4347183A 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
JPS588084A * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
US4742052A * 1981-07-15 1988-05-03 Sumitomo Pharmaceuticals Company, Limited Antibacterial β-lactam compounds
JPS58116487A * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
JPS58198486A * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS5835190A * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
CA1190236A * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
US4411906A * 1981-11-25 1983-10-25 Schering Corporation (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates
NL8204720A * 1981-12-11 1983-07-01 Erba Farmitalia Werkwijze voor het bereiden van optisch actieve penemverbindingen.
NO831160L * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
JPS591464A * 1982-06-26 1984-01-06 Sankyo Co Ltd β−ラクタム化合物及びその製法
NZ204829A * 1982-07-08 1986-07-11 Hoechst Uk Ltd Penems and pharmaceutical compositions:intermediates
DE3366926D1 * 1982-11-16 1986-11-20 Schering Corp Penems, pharmaceutical compositions containing them, process for preparing them
PH21930A * 1982-11-16 1988-04-08 Ciba Geigy Ag 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
EP0112283B1 * 1982-11-16 1987-08-12 Ciba-Geigy Ag Heterocyclylthioverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
EP0109362A1 * 1982-11-16 1984-05-23 Ciba-Geigy Ag Heterocyclylverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
US4540579A * 1982-11-16 1985-09-10 Schering Corporation 2-[(R) Amino acid alkyl]penems
US4540580A * 1982-11-16 1985-09-10 Schering Corporation 2-[(1'R)-1'-Aminoalkyl]penems
US4435413A 1983-01-28 1984-03-06 Schering Corporation (5R-6S,8R)-6-(1-Hydroxyethyl)-2-(2-glycylaminoethylthio)-penem-3-carboxylic acid
EP0345827A1 * 1982-11-29 1989-12-13 Schering Corporation Process for the production of penem compounds
FI77459C * 1982-12-08 1989-03-10 Erba Farmitalia Foerfarande foer framstaellning av (5r)-penemderivat.
JPS59152387A * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物
DK141784A * 1983-03-14 1984-09-15 Schering Corp Penemforbindelser, fremgangsmaader til deres fremstilling samt farmaceutiske praeparater indeholdende disse
EP0125208A1 * 1983-05-06 1984-11-14 Ciba-Geigy Ag Aminoniederalkyl-penem-Verbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
EP0125207A1 * 1983-05-06 1984-11-14 Ciba-Geigy Ag 2-Tetrazolylpropyl-2-penem-Verbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
CA1283906C * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4725678A * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
US4595539A * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4619783A * 1983-06-10 1986-10-28 Pfizer Inc. Process and intermediates for the preparation of penem derivatives
US4554103A * 1983-07-14 1985-11-19 Schering Corporation Preparation of 4-acyloxyazetidinones from acyl nitrates and penams
GB8321677D0 * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4584133A * 1983-11-07 1986-04-22 Schering Corporation Process for the production of penems
US4587241A * 1983-11-28 1986-05-06 Schering Corporation Heterocyclic substituted penems
US5229381A * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
US4680391A * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4711886A * 1984-07-02 1987-12-08 Merck & Co., Inc. β-lactam derivatives as anti-inflammatory and antidegenerative agents
JPS62501556A * 1984-07-13 1987-06-25 メルシャン株式会社 新規２↓−オキソアゼチジン類、その製造方法および応用
US4617300A * 1984-09-21 1986-10-14 Schering Corporation 2(N-heterocyclyl) penems
EP0181831B1 * 1984-10-01 1993-08-25 Ciba-Geigy Ag Verfahren zur Herstellung von optisch aktiven Acyloxyazetidinonen
US4761408A * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
JPH075463B2 * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0199675A1 * 1985-04-17 1986-10-29 Ciba-Geigy Ag Heterocyclyl-penem-Verbindungen
EP0232966B1 * 1986-01-17 1997-10-08 Beecham Group Plc Process for the preparation of penem compounds and intermediates for this preparation
US4806637A * 1986-03-17 1989-02-21 Schering Corporation 6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates
US4826832A * 1986-05-06 1989-05-02 Ciba-Geigy Corporation Penen compounds
JP2526046B2 * 1986-12-26 1996-08-21 サントリー株式会社 ペネム誘導体、その製造法およびその用途
ES2058328T3 * 1987-02-11 1994-11-01 Ciba Geigy Ag Acidos beta-lactama carboxilicos biciclicos.
US4751297A * 1987-03-20 1988-06-14 Pfizer Inc. Method for preparation of azetidinone-1-oxoacetate by oxidation of the corresponding 2-hydroxyacetate
GB8713515D0 * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
AT392903B * 1987-10-08 1991-07-10 Hoechst Ag Pharmazeutische zubereitung enthaltend ein cephalosporin und ein penemantibiotikum
DE3839987A1 * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung
US4876365A * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US5198544A * 1989-04-29 1993-03-30 Hoechst Aktiengesellschaft Process for the preparation of penem compounds
US5104862A * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5100880A * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
GB9110507D0 * 1991-05-15 1991-07-03 Smithkline Beecham Plc Chemical compounds
US5348953A * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
GB9216102D0 * 1992-07-29 1992-09-09 Smithkline Beecham Plc Pharmaceutical substances
JPH08502752A * 1992-10-27 1996-03-26 メルク エンド カンパニー インコーポレーテッド 抗炎症剤及び抗変性剤としての新規の置換アゼチジノン
US5591737A * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
DE69629152T2 * 1995-02-17 2004-07-08 Daiichi Suntory Pharma Co., Ltd. Penem-derivate und sie enthaltende anti-mikrobische mittel
US5747485A * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
KR20000076105A * 1998-01-13 2000-12-26 도리이 신이찌로 항생제를 함유한 국소 투여용 항균 조성물
JP2005239696A 2004-01-30 2005-09-08 Daiichi Suntory Pharma Co Ltd 無機物質を配合した医薬硬質カプセル剤
CN101029056B * 2006-02-28 2011-06-08 天津国韵生物材料有限公司 聚-3-羟基丁酸酯在制备β-内酰胺化合物中的用途
JP5733856B2 * 2007-10-09 2015-06-10 ソファーミア，インコーポレイテッド 広帯域β−ラクタマーゼ阻害薬
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* Cited by examiner, † Cited by third party, ‡ Family to family citation

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Priority And Related Applications

Applications Claiming Priority (1)

Application Filing date Title
CH114078 1978-02-02

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