ES8105329A1 - Procedimiento para la obtencion de compuestos de acido ami- notiazolacetamido-3-cefem-4-carboxilico. - Google Patents

Procedimiento para la obtencion de compuestos de acido ami- notiazolacetamido-3-cefem-4-carboxilico.

Info

Publication number
ES8105329A1
ES8105329A1 ES492990A ES492990A ES8105329A1 ES 8105329 A1 ES8105329 A1 ES 8105329A1 ES 492990 A ES492990 A ES 492990A ES 492990 A ES492990 A ES 492990A ES 8105329 A1 ES8105329 A1 ES 8105329A1
Authority
ES
Spain
Prior art keywords
group
compounds
preparation
manufacture
represents hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492990A
Other languages
English (en)
Other versions
ES492990A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8105329A1 publication Critical patent/ES8105329A1/es
Publication of ES492990A0 publication Critical patent/ES492990A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DEL ACIDO AMINOTIAZOLACETAMIDO-3-CEFEM-4-CARBOXILICO. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA GENERAL (I) O UNA SAL DEL MISMO CON UNA TIOUREA DE FORMULA HOOC-CH-(CNH2N)-X-C-NH-CS-NH2, DONDE LOS GRUPOS FUNCIONALES ESTAN PROTEGIDOS. OPCIONALMENTE, SE SEPARA LA MEZCLA DE ISOMEROS OBTENIDA EN LOS ISOMEROS INDIVIDUALES Y/O EL COMPUESTO OBTENIDO SE TRANSFORMA EN LA SAL CORRESPONDIENTE. LOS GRUPOS FUNCIONALES PROTEGIDOS SE LIBERAN MEDIANTE SOLVOLISIS O REDUCCION. SE FORMA UN PRODUCTO DE PARTIDA <<IN SITU>>; EN CASO DADO, BAJO LAS CONDICIONES DE REACCION O EL MATERIAL DE PARTIDA SE EMPLEA EN FORMA DE SAL. *FORMULA* TRATAMIENTO DE INFECCIONES.
ES492990A 1978-11-23 1980-07-01 Procedimiento para la obtencion de compuestos de acido ami- notiazolacetamido-3-cefem-4-carboxilico. Granted ES492990A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1202578 1978-11-23

Publications (2)

Publication Number Publication Date
ES8105329A1 true ES8105329A1 (es) 1981-06-01
ES492990A0 ES492990A0 (es) 1981-06-01

Family

ID=4379139

Family Applications (3)

Application Number Title Priority Date Filing Date
ES486198A Granted ES486198A0 (es) 1978-11-23 1979-11-21 Procedimiento para la obtencion de compuestos de acido aminotiazolacetamino-3-cefem-4-carboxilico
ES492989A Granted ES492989A0 (es) 1978-11-23 1980-07-01 Procedimiento para la obtencion de compuestos de acido ami- notiazolacetamido-3-cefem-4-carboxilico
ES492990A Granted ES492990A0 (es) 1978-11-23 1980-07-01 Procedimiento para la obtencion de compuestos de acido ami- notiazolacetamido-3-cefem-4-carboxilico.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES486198A Granted ES486198A0 (es) 1978-11-23 1979-11-21 Procedimiento para la obtencion de compuestos de acido aminotiazolacetamino-3-cefem-4-carboxilico
ES492989A Granted ES492989A0 (es) 1978-11-23 1980-07-01 Procedimiento para la obtencion de compuestos de acido ami- notiazolacetamido-3-cefem-4-carboxilico

Country Status (10)

Country Link
US (1) US4313945A (es)
EP (1) EP0016296A1 (es)
JP (1) JPS5573692A (es)
AU (1) AU531190B2 (es)
CA (1) CA1146535A (es)
DK (1) DK496279A (es)
ES (3) ES486198A0 (es)
IL (1) IL58777A (es)
NZ (1) NZ192207A (es)
ZA (1) ZA796331B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77786A1 (de) * 1977-07-15 1979-03-26 Ciba Geigy Ag Verfahren zur herstellung neuer benzopyranderivate
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4464366A (en) * 1979-12-19 1984-08-07 Ciba Geigy Corporation Cephem compounds having a terminal aminocarboxylic acid grouping and containing an azacyclyl(thio)ureido group
JPS56166139A (en) * 1980-05-28 1981-12-21 Toa Nenryo Kogyo Kk Preparation of aldehyde
EP0059683A3 (de) * 1981-02-27 1982-12-01 Ciba-Geigy Ag 7-Acylamido-3-cephem-4-carbonsäureverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
FI922867A (fi) * 1991-06-21 1992-12-22 Tanabe Seiyaku Co Dikarbonsyraderivat och foerfarande foer framstaellning av dem
JPH06199850A (ja) * 1992-12-28 1994-07-19 Tanabe Seiyaku Co Ltd インドール含有ペプチド及びその製法
US6258962B1 (en) 1999-06-14 2001-07-10 Mobil Oil Corp. Process for producing alkylene carbonates
CA2721134C (en) 2007-06-13 2017-02-07 Wayne State University Board Of Governors A baclofen solution for low-volume therapeutic delivery
WO2008157308A2 (en) * 2007-06-13 2008-12-24 Wayne State University Board Of Governors A zwitterion solution for low-volume therapeutic delivery
BR112017022024A2 (pt) 2015-04-15 2018-07-03 Henkel Ag & Co. Kgaa revestimentos protetores de corrosão fina incorporando polímeros de poliamidoamina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007173A (en) * 1973-05-07 1977-02-08 Smithkline Corporation α-amino-α-(ureidophenyl)acetamidocephalosporins
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4202893A (en) * 1976-03-25 1980-05-13 Roussel Uclaf Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
EP0000500B1 (de) * 1977-07-18 1982-04-28 Ciba-Geigy Ag Cephalosporinderivate, Verfahren zu deren Herstellung und deren pharmazeutische Präparate
US4242509A (en) * 1979-04-13 1980-12-30 Eli Lilly And Company Process for producing 7-amino-7-alkoxycephalosporins

Also Published As

Publication number Publication date
EP0016296A1 (de) 1980-10-01
US4313945A (en) 1982-02-02
AU531190B2 (en) 1983-08-11
ES492990A0 (es) 1981-06-01
DK496279A (da) 1980-05-24
CA1146535A (en) 1983-05-17
IL58777A0 (en) 1980-02-29
ZA796331B (en) 1980-11-26
NZ192207A (en) 1982-03-09
ES8105328A1 (es) 1981-06-01
ES492989A0 (es) 1981-06-01
JPS5573692A (en) 1980-06-03
ES8100303A1 (es) 1980-11-01
IL58777A (en) 1983-06-15
AU5310179A (en) 1980-05-29
ES486198A0 (es) 1980-11-01

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