ES8607971A1 - Procedimiento para la obtencion de compuestos de 2-heterociclil-tio-alquilo inferior-penem - Google Patents

Procedimiento para la obtencion de compuestos de 2-heterociclil-tio-alquilo inferior-penem

Info

Publication number
ES8607971A1
ES8607971A1 ES527260A ES527260A ES8607971A1 ES 8607971 A1 ES8607971 A1 ES 8607971A1 ES 527260 A ES527260 A ES 527260A ES 527260 A ES527260 A ES 527260A ES 8607971 A1 ES8607971 A1 ES 8607971A1
Authority
ES
Spain
Prior art keywords
compounds
formula
heterocyclyl
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527260A
Other languages
English (en)
Other versions
ES527260A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES527260A0 publication Critical patent/ES527260A0/es
Publication of ES8607971A1 publication Critical patent/ES8607971A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS 2-HETEROCICLILTIO-ALQUILO INFERIOR-PENEM, DE SUS SALES, DE SUS ISOMEROS, DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO O METILO; R2 ES HIDROXILO; R3 ES CARBOXILO O CARBOXILO PROTEGIDO; R4 ES UN RESTO HETEROCICLICO O MONOCICLICO INSATURADO; Y M VALE 2-4. COMPRENDE LA REACCION DE CICLIZACION DE UN COMPUESTO ILIDA, DE FORMULA (II), EN LA QUE Z REPRESENTA OXIGENO O AZUFRE, XB ES UN GRUPO FOSFONIO TRISUSTITUIDO O UN GRUPO FOSFONO DIESTERIFICADO JUNTO CON UN CATION; Y LOS DEMAS SIMBOLOS SON LOS MISMOS QUE EN LA FORMULA (I). LA CICLIZACION SE EFECTUA MEDIANTE CALENTAMIENTO A UNA TEMPERATURA COMPRENDIDA ENTRE 30JC Y 160JC, EN UN DISOLVENTE INERTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFECCIONES.
ES527260A 1982-11-16 1983-11-14 Procedimiento para la obtencion de compuestos de 2-heterociclil-tio-alquilo inferior-penem Expired ES8607971A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH667182 1982-11-16

Publications (2)

Publication Number Publication Date
ES527260A0 ES527260A0 (es) 1986-06-01
ES8607971A1 true ES8607971A1 (es) 1986-06-01

Family

ID=4313203

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527260A Expired ES8607971A1 (es) 1982-11-16 1983-11-14 Procedimiento para la obtencion de compuestos de 2-heterociclil-tio-alquilo inferior-penem

Country Status (16)

Country Link
US (1) US4616007A (es)
EP (1) EP0112283B1 (es)
JP (1) JPS59101493A (es)
KR (1) KR840006664A (es)
AU (1) AU2138983A (es)
DD (1) DD214132A5 (es)
DE (1) DE3372968D1 (es)
DK (1) DK522883A (es)
ES (1) ES8607971A1 (es)
FI (1) FI834140A (es)
GR (1) GR79432B (es)
IL (1) IL70233A0 (es)
NO (1) NO834190L (es)
NZ (1) NZ206273A (es)
PT (1) PT77659B (es)
ZA (1) ZA838463B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
EP0184844A1 (en) * 1984-12-13 1986-06-18 Merck & Co. Inc. 1-Methylcarbapenems having a 2-position substituent joined through an alkylenethio bridge
EP0186057A1 (en) * 1984-12-13 1986-07-02 Merck & Co. Inc. Carbapenems having a 2-position substituent joined through an alkyleneheteroatom bridge
US5736522A (en) * 1993-11-15 1998-04-07 Kureha Chemical Industry Co., Ltd. Esculetin derivatives and method for manufacture thereof, use thereof, and pharmaceutical composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
FI75163C (fi) * 1979-02-24 1988-05-09 Erba Farmitalia Foerfarande foer framstaellning av nya penemkarboxylsyror eller -estrar.
IT1190842B (it) * 1981-06-30 1988-02-24 Erba Farmitalia Via di sintesi di derivati otticamente attivi dell'acido 2-penem-3-carbossilico
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法

Also Published As

Publication number Publication date
FI834140A (fi) 1984-05-17
KR840006664A (ko) 1984-12-01
EP0112283B1 (de) 1987-08-12
JPS59101493A (ja) 1984-06-12
EP0112283A1 (de) 1984-06-27
DE3372968D1 (en) 1987-09-17
DK522883D0 (da) 1983-11-15
NZ206273A (en) 1986-04-11
US4616007A (en) 1986-10-07
ZA838463B (en) 1984-06-27
PT77659A (en) 1983-12-01
IL70233A0 (en) 1984-02-29
AU2138983A (en) 1984-05-24
FI834140A0 (fi) 1983-11-11
ES527260A0 (es) 1986-06-01
PT77659B (en) 1986-07-17
NO834190L (no) 1984-05-18
DD214132A5 (de) 1984-10-03
GR79432B (es) 1984-10-22
DK522883A (da) 1984-05-17

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