ES8704953A1 - Procedimiento para la obtencion de derivados de 2-aminometil-2-penem. - Google Patents

Procedimiento para la obtencion de derivados de 2-aminometil-2-penem.

Info

Publication number
ES8704953A1
ES8704953A1 ES549383A ES549383A ES8704953A1 ES 8704953 A1 ES8704953 A1 ES 8704953A1 ES 549383 A ES549383 A ES 549383A ES 549383 A ES549383 A ES 549383A ES 8704953 A1 ES8704953 A1 ES 8704953A1
Authority
ES
Spain
Prior art keywords
compounds
formula
aminomethyl
amino
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549383A
Other languages
English (en)
Other versions
ES549383A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH2510/84A external-priority patent/CH662119A5/de
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8704953A1 publication Critical patent/ES8704953A1/es
Publication of ES549383A0 publication Critical patent/ES549383A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL 2-AMINOMETIL-2-PENEM, DE CONFIGURACION (5R, 6S), OPTICAMENTE PUROS, Y DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SOMETER A UN COMPUESTO ILIDA DE FORMULA GENERAL (I), EN LA QUE R1 SIGNIFICA ALQUILO INFERIOR SUSTITUIDO POR HIDROXI O HIDROXI PROTEGIDO; R2 SAIGNIFICA CARBOXILO O CARBOXILO FUNCIONALMENTE MODIFICADO; R3 SIGNIFICA AMINO O AMINO SUSTITUIDO POR ALQUILO INFERIOR; RK2 SIGNIFICA UN GRUPO CARBOXILO PROTEGIDO; Z ES OXIGENO O AZUFRE; Y X REPRESENTA UN GRUPO FOSFONIO TRES VECES SUSTITUIDO O UN GRUPO FOSFONIO DOS VECES ESTERIFICADO, JUNTO CON UN CATION, A UN PROCESO DE CALENTAMIENTO EN UN MARGEN DE TEMPERATURAS COMPRENDIDO ENTRE 30 Y 160 GRADOS. DE APLICACION COMO ANTIBIOTICOS.
ES549383A 1983-09-02 1985-11-28 Procedimiento para la obtencion de derivados de 2-aminometil-2-penem. Expired ES8704953A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH483183 1983-09-02
CH2510/84A CH662119A5 (en) 1984-05-22 1984-05-22 Aminomethyl-penem compounds

Publications (2)

Publication Number Publication Date
ES8704953A1 true ES8704953A1 (es) 1987-04-16
ES549383A0 ES549383A0 (es) 1987-04-16

Family

ID=25690638

Family Applications (3)

Application Number Title Priority Date Filing Date
ES535582A Expired ES8701763A1 (es) 1983-09-02 1984-08-31 Procedimiento para la obtencion de derivados del 2-aminometil-2-penem
ES549383A Expired ES8704953A1 (es) 1983-09-02 1985-11-28 Procedimiento para la obtencion de derivados de 2-aminometil-2-penem.
ES549384A Expired ES8704954A1 (es) 1983-09-02 1985-11-28 Procedimiento para la obtencion de derivados del 2-aminome- til-2-penem.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES535582A Expired ES8701763A1 (es) 1983-09-02 1984-08-31 Procedimiento para la obtencion de derivados del 2-aminometil-2-penem

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES549384A Expired ES8704954A1 (es) 1983-09-02 1985-11-28 Procedimiento para la obtencion de derivados del 2-aminome- til-2-penem.

Country Status (20)

Country Link
US (1) US4656165A (es)
AT (1) ATA279784A (es)
AU (1) AU3264484A (es)
BE (1) BE900477A (es)
DD (1) DD222314A5 (es)
DE (1) DE3431980A1 (es)
DK (1) DK419084A (es)
ES (3) ES8701763A1 (es)
FI (1) FI843427A (es)
FR (1) FR2551441A1 (es)
GB (2) GB2146021B (es)
GR (1) GR80270B (es)
HU (1) HU193054B (es)
IL (1) IL72831A (es)
IT (1) IT1177980B (es)
LU (1) LU85519A1 (es)
NL (1) NL8402668A (es)
NO (2) NO843469L (es)
PT (1) PT79143B (es)
SE (1) SE8404297L (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
US5215997A (en) * 1985-09-11 1993-06-01 Ciba-Geigy Corporation Synthesis of beta-lactam compounds
DE3688960D1 (de) * 1985-09-11 1993-10-07 Ciba Geigy Synthese von Beta-Lactamverbindungen.
EP0290385B1 (de) 1987-05-04 1992-10-21 Ciba-Geigy Ag Neues Verfahren zur Herstellung von 4-Acyloxy-3-hydroxyethyl-azetidinonen
EP0597401A3 (en) * 1992-11-11 1995-07-26 Takeda Chemical Industries Ltd Preparation of penemes.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
FI75163C (fi) * 1979-02-24 1988-05-09 Erba Farmitalia Foerfarande foer framstaellning av nya penemkarboxylsyror eller -estrar.
US4386030A (en) * 1979-12-31 1983-05-31 Merck & Co., Inc. Process for preparing 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
JPS56166194A (en) * 1980-05-27 1981-12-21 Sankyo Co Ltd Penem derivative and its preparation
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
DE3277696D1 (en) * 1981-07-15 1987-12-23 Sumitomo Pharma Carboxylic beta-lactam compounds and the preparation thereof
EP0109044B1 (en) * 1982-11-16 1986-10-15 Schering Corporation Penems, pharmaceutical compositions containing them, process for preparing them

Also Published As

Publication number Publication date
FI843427A (fi) 1985-03-03
IL72831A (en) 1987-12-31
ES549383A0 (es) 1987-04-16
GR80270B (en) 1985-01-02
FR2551441A1 (fr) 1985-03-08
ATA279784A (de) 1987-08-15
DE3431980A1 (de) 1985-04-18
SE8404297D0 (sv) 1984-08-29
US4656165A (en) 1987-04-07
ES8704954A1 (es) 1987-04-16
ES549384A0 (es) 1987-04-16
GB2183230B (en) 1988-01-13
LU85519A1 (de) 1985-04-24
GB8421773D0 (en) 1984-10-03
BE900477A (fr) 1985-02-28
IT1177980B (it) 1987-09-03
FI843427A0 (fi) 1984-08-31
NO850932L (no) 1985-03-04
DK419084A (da) 1985-03-03
IT8448789A1 (it) 1986-03-03
HUT34983A (en) 1985-05-28
GB2146021B (en) 1988-01-13
ES535582A0 (es) 1986-12-01
IT8448789A0 (it) 1984-08-31
PT79143B (en) 1986-11-14
AU3264484A (en) 1985-03-07
NL8402668A (nl) 1985-04-01
HU193054B (en) 1987-08-28
DD222314A5 (de) 1985-05-15
GB2183230A (en) 1987-06-03
PT79143A (en) 1984-09-01
IL72831A0 (en) 1984-11-30
DK419084D0 (da) 1984-08-31
NO843469L (no) 1985-03-04
GB2146021A (en) 1985-04-11
SE8404297L (sv) 1985-03-03
GB8625937D0 (en) 1986-12-03
ES8701763A1 (es) 1986-12-01

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