ES8403866A1 - Un metodo de producir un derivado de 4-ciano-2-azetidinona. - Google Patents

Un metodo de producir un derivado de 4-ciano-2-azetidinona.

Info

Publication number
ES8403866A1
ES8403866A1 ES518562A ES518562A ES8403866A1 ES 8403866 A1 ES8403866 A1 ES 8403866A1 ES 518562 A ES518562 A ES 518562A ES 518562 A ES518562 A ES 518562A ES 8403866 A1 ES8403866 A1 ES 8403866A1
Authority
ES
Spain
Prior art keywords
group
acylated
image
protected
amino group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518562A
Other languages
English (en)
Other versions
ES518562A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56212718A external-priority patent/JPS58110563A/ja
Priority claimed from PCT/JP1982/000141 external-priority patent/WO1983003827A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES518562A0 publication Critical patent/ES518562A0/es
Publication of ES8403866A1 publication Critical patent/ES8403866A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

METODO DE PRODUCIR UN DERIVADO DE 4-CIANO-2-AZETIDINONA.C ONSISTE EN REACCIONAR COMPUESTO DE FORMULA (II) CON UN COMPUESTO CIANO, Y ELIMINAR EL GRUPO PROTECTOR, PARA DAR UN DERIVADO DE 4-CIANO-2-AZETIDINONA DE FORMULA (I), DONDE R1 ES UN GRUPO AMINO QUE PUEDE ESTAR ACILADO O PROTEGIDO; X ES UN ATOMO DE HIDROGENO, UN GRUPO METOXI; W ES UN HIDROGENO, UN GRUPO SULFO, UNA SAL O UN ESTER DEL MISMO; R2 ES UN AMINO ACILADO O PROTEGIDO E Y ES UN ATOMO DE HALOGENO, UN GRUPO DE FORMULA -OCOR3, -SCOR3, O -S(O)N-R3, SIENDO R3 UN GRUPO HIDROCARBILO Y NO UN ENTERO DE VALOR 1 O 2. LA REACCIONSE EFECTUA EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASE TALES COMO CLORURO DE TETRA-N-BUTILAMONIO, BROMURO DE TETRA N-AMILAMONIO Y OTROS.TIENE APLICACION PARA LA OBTENCION DE FORMAS OPTICAMENTE ACTIVAS, ALGUNAS DE LAS CUALES PRESENTAN ACTIVIDAD ANTIMICROBIANA E INHIBIDORA.
ES518562A 1981-12-25 1982-12-24 Un metodo de producir un derivado de 4-ciano-2-azetidinona. Expired ES8403866A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56212718A JPS58110563A (ja) 1981-12-25 1981-12-25 ４−シアノ−２−アゼチジノン誘導体およびその製造法
PCT/JP1982/000141 WO1983003827A1 (en) 1982-04-27 1982-04-27 4-cyano-2-azetidinone derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
ES518562A0 ES518562A0 (es) 1984-02-01
ES8403866A1 true ES8403866A1 (es) 1984-02-01

Family

ID=26422990

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518562A Expired ES8403866A1 (es) 1981-12-25 1982-12-24 Un metodo de producir un derivado de 4-ciano-2-azetidinona.

Country Status (11)

Country Link
US (2) US4560508A (es)
EP (1) EP0083039B1 (es)
KR (1) KR890003423B1 (es)
AU (1) AU557575B2 (es)
CA (1) CA1212112A (es)
DK (1) DK570082A (es)
ES (1) ES8403866A1 (es)
GB (1) GB2114977B (es)
HU (1) HU192780B (es)
IL (1) IL67451A (es)
NO (1) NO160996C (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117053A1 (en) * 1983-02-10 1984-08-29 Ajinomoto Co., Inc. Azetidinone derivatives
DE3686632T2 (de) * 1985-04-30 1993-01-21 Takeda Chemical Industries Ltd Antibiotische derivate, ihre herstellung und verwendung.
DE102006055430A1 (de) * 2006-11-22 2008-05-29 Evonik Röhm Gmbh Verfahren zur Herstellung von Carbonsäureamiden durch Hydrolyse von Carbonsäurenitrilen in Gegenwart eines Mangandioxid umfassenden Katalysators
LT3122745T (lt) 2014-03-24 2019-04-10 Novartis Ag Monobaktamo organiniai junginiai, skirti bakterinių infekcijų gydymui
WO2017050218A1 (en) 2015-09-23 2017-03-30 Novartis Ag Salts and solid forms of monobactam antibiotic
US11414411B2 (en) 2017-08-02 2022-08-16 Novartis Ag Chemical process for manufacturing monobactam antibiotic and intermediates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166816A (en) * 1975-05-05 1979-09-04 Smithkline Corporation Methods and intermediates for preparing cis-4-oxoazetidine intermediates
US4200572A (en) * 1975-09-03 1980-04-29 Smithkline Corporation Substituted azetidinones
CA1242188A (en) * 1979-06-08 1988-09-20 Takeda Pharmaceutical Company Limited 3-methoxy-2-oxoazetidine derivatives and their production
NZ205240A (en) * 1980-02-07 1984-07-31 Squibb & Sons Inc Sulphonamide derivatives,being starting materials for producing beta-lactams
WO1982001705A1 (en) * 1980-11-13 1982-05-27 Takeda Chemical Industries Ltd 4-substituted-2-oxoazetidine derivatives and process for their preparation
WO1982001873A1 (en) * 1980-12-05 1982-06-10 Takeda Chemical Industries Ltd 1-sulfo-2-oxoazetidine derivatives and process for their preparation

Also Published As

Publication number Publication date
GB2114977B (en) 1985-08-29
EP0083039B1 (en) 1986-03-19
NO160996B (no) 1989-03-13
ES518562A0 (es) 1984-02-01
US4560508A (en) 1985-12-24
NO824312L (no) 1983-06-27
IL67451A0 (en) 1983-05-15
IL67451A (en) 1987-10-20
HU192780B (en) 1987-07-28
KR890003423B1 (ko) 1989-09-20
AU557575B2 (en) 1986-12-24
CA1212112A (en) 1986-09-30
AU9164282A (en) 1983-06-30
DK570082A (da) 1983-06-26
GB2114977A (en) 1983-09-01
EP0083039A1 (en) 1983-07-06
KR840002807A (ko) 1984-07-21
US4684724A (en) 1987-08-04
NO160996C (no) 1989-06-21

Similar Documents

Publication Publication Date Title
ES8607287A1 (es) Un procedimiento para preparar derivados de 1,8-naftiridina
CA2114114A1 (en) Trisubstituted phenyl derivatives as selective phosphodiesterase iv inhibitors
TW325473B (en) Azoamine derivative having methylene or substituted methylene on the amino ring
ES8704955A1 (es) Un proceso para la produccion de un compuesto de cefalospo- rina
ZA888448B (en) Novel compounds
ES2000185A6 (es) Procedimiento para preparar derivados de acidos piridoncaboxilicos
TW368501B (en) 7-(2-aminoethyl)-benzothiazolones
FR2495612B1 (es)
MY117092A (en) Chemotherapeutic pyrrolocarbazole derivatives
ES8403866A1 (es) Un metodo de producir un derivado de 4-ciano-2-azetidinona.
DE69119668T2 (de) Hemmungsstoff für Aldosereduktase
MY109714A (en) Process for preparing 8-chloroquinolone derivatives
ATE148128T1 (de) Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
CA2093510A1 (en) Oxysulfonyl carbamates
ES8200113A1 (es) Un procedimiento para la preparacion de derivados de cefalosporina.
AU5674894A (en) Azanoradamantanes
HUP0000783A2 (hu) N-(piridinil-amino)-izoindolinok és származékaik, eljárás előállításukra, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ES8100304A1 (es) Un procedimiento para preparar derivados de indol policiclicos
CA2056334A1 (en) Process for producing benzylphthalazinone derivatives and salts thereof
BG60248B2 (en) Process for the preparation of phenoxyethylamine derivatives
ES8302093A1 (es) Un procedimiento para obtener nuevos compuestos de beta-lac-tama
EP0590681A3 (en) A process for the preparation of aminothiadiazolylacetyl halide derivatives
TW353662B (en) Cephalosporin salts and process for the preparation thereof
TW371304B (en) Cephem compounds having antibacterial activity, their production and pharmaceutical composition
ES8506725A1 (es) Procedimiento para la preparacion de un derivado de cefalosporina

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103