JPS56166194A - Penem derivative and its preparation - Google Patents
Penem derivative and its preparationInfo
- Publication number
- JPS56166194A JPS56166194A JP7068880A JP7068880A JPS56166194A JP S56166194 A JPS56166194 A JP S56166194A JP 7068880 A JP7068880 A JP 7068880A JP 7068880 A JP7068880 A JP 7068880A JP S56166194 A JPS56166194 A JP S56166194A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- group
- penem
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Penem derivatives of formula I [R1 is amino, hydroxyl, carbamoyl, group of R2-N=C(R3)-NH-(R2 and R3 are H, alkyl); A is alkylene] and their pharmacologically permissible salts or their biologically active esters.
EXAMPLE: 6-( 1'-Hydroxyethyl )-2-aminomethyl-2-penem-3-carboxylic acid or its sodium salt.
USE: Antibiotic: they show antibiotic activities against a wide range of pathogenic bacteria including gram-positive and -negative bacteria. These compounds are modeled on thienamycin of strong antibiotic activity.
PREPARATION: The phosphonium ylide of formula 5 (R1' is protected amino group; R4 is hydroxyl-protecting group; R5 is protecting group; R6 is alkyl, acryl) is heated to give a compound of formula 6 and protecting groups are removed from the compound of formula 6 to produce the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7068880A JPS56166194A (en) | 1980-05-27 | 1980-05-27 | Penem derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7068880A JPS56166194A (en) | 1980-05-27 | 1980-05-27 | Penem derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56166194A true JPS56166194A (en) | 1981-12-21 |
JPH0371434B2 JPH0371434B2 (en) | 1991-11-13 |
Family
ID=13438824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7068880A Granted JPS56166194A (en) | 1980-05-27 | 1980-05-27 | Penem derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56166194A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2551441A1 (en) * | 1983-09-02 | 1985-03-08 | Ciba Geigy Ag | AMINOMETHYL-2-PENEM DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS |
-
1980
- 1980-05-27 JP JP7068880A patent/JPS56166194A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2551441A1 (en) * | 1983-09-02 | 1985-03-08 | Ciba Geigy Ag | AMINOMETHYL-2-PENEM DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS |
US4656165A (en) * | 1983-09-02 | 1987-04-07 | Ciba-Geigy Corporation | Aminomethyl penem compounds |
Also Published As
Publication number | Publication date |
---|---|
JPH0371434B2 (en) | 1991-11-13 |
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