JPS5762287A - Cephalosporin compound for oral administration - Google Patents

Cephalosporin compound for oral administration

Info

Publication number
JPS5762287A
JPS5762287A JP56111440A JP11144081A JPS5762287A JP S5762287 A JPS5762287 A JP S5762287A JP 56111440 A JP56111440 A JP 56111440A JP 11144081 A JP11144081 A JP 11144081A JP S5762287 A JPS5762287 A JP S5762287A
Authority
JP
Japan
Prior art keywords
compound
lower alkyl
formula
oral administration
formulai
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56111440A
Other languages
Japanese (ja)
Other versions
JPS609757B2 (en
Inventor
Hideo Nakao
Koichi Fujimoto
Sadao Ishihara
Shinichi Sugawara
Isamu Igarashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP56111440A priority Critical patent/JPS609757B2/en
Publication of JPS5762287A publication Critical patent/JPS5762287A/en
Publication of JPS609757B2 publication Critical patent/JPS609757B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

NEW MATERIAL:A compound (syn isomer) of formulaI[R1 is H or lower alkyl; R2 is lower alkyl; Y is phthalidyl or a group of formula II (R3 is H or CH3; R4 is lower alkyl or lower lakoxyl)]and a pharmacologically acceptable acid addition salt thereof.
EXAMPLE: Pivaloyloxymethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylate.
USE: An antimicrobial agent for oral administration, having good absorption from the digestive tracts, and capable of decomposing the ester part at the 4-positin rapidly in the living body to form the carboxylic acid type.
PROCESS: A compound of formula III is reacted with a compound of formula IV (R5 is optionally protected NH2; R6 is optionally protected OH or lower alkoxyl) or a reactive derivative thereof, and if necessary the protecting groups are removed to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56111440A 1981-07-16 1981-07-16 Oral Cephalosporin Compound Expired JPS609757B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56111440A JPS609757B2 (en) 1981-07-16 1981-07-16 Oral Cephalosporin Compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56111440A JPS609757B2 (en) 1981-07-16 1981-07-16 Oral Cephalosporin Compound

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP55136449A Division JPS5759894A (en) 1980-09-30 1980-09-30 Cephalosporin for oral administration

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP59028219A Division JPH0631259B2 (en) 1984-02-17 1984-02-17 Oral cefalosporin compound

Publications (2)

Publication Number Publication Date
JPS5762287A true JPS5762287A (en) 1982-04-15
JPS609757B2 JPS609757B2 (en) 1985-03-12

Family

ID=14561248

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56111440A Expired JPS609757B2 (en) 1981-07-16 1981-07-16 Oral Cephalosporin Compound

Country Status (1)

Country Link
JP (1) JPS609757B2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034976A (en) * 1984-02-17 1985-02-22 Sankyo Co Ltd Cephalosporin compound for oral administration
JPH01249778A (en) * 1988-02-17 1989-10-05 Hoechst Ag Cephalosporine derivative and its production
JPH0273090A (en) * 1988-08-23 1990-03-13 Bristol Myers Co Novel production of cephem prodrug ester
US5067625A (en) * 1989-06-05 1991-11-26 Nifco Inc. Device for opening and closing lid

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034976A (en) * 1984-02-17 1985-02-22 Sankyo Co Ltd Cephalosporin compound for oral administration
JPH01249778A (en) * 1988-02-17 1989-10-05 Hoechst Ag Cephalosporine derivative and its production
JPH0273090A (en) * 1988-08-23 1990-03-13 Bristol Myers Co Novel production of cephem prodrug ester
US5067625A (en) * 1989-06-05 1991-11-26 Nifco Inc. Device for opening and closing lid

Also Published As

Publication number Publication date
JPS609757B2 (en) 1985-03-12

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term