ES8304534A1 - "procedimiento de preparacion de derivados de 1-fenil-1-hidroxi-etilamina". - Google Patents

"procedimiento de preparacion de derivados de 1-fenil-1-hidroxi-etilamina".

Info

Publication number
ES8304534A1
ES8304534A1 ES513109A ES513109A ES8304534A1 ES 8304534 A1 ES8304534 A1 ES 8304534A1 ES 513109 A ES513109 A ES 513109A ES 513109 A ES513109 A ES 513109A ES 8304534 A1 ES8304534 A1 ES 8304534A1
Authority
ES
Spain
Prior art keywords
group
image
carbon atoms
preparation
groups containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513109A
Other languages
English (en)
Other versions
ES513109A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Draco AB
Original Assignee
Draco AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draco AB filed Critical Draco AB
Publication of ES8304534A1 publication Critical patent/ES8304534A1/es
Publication of ES513109A0 publication Critical patent/ES513109A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 1-FENIL-1-HIDROXI-ETILAMINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R, R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REDUCCION SE LLEVA A CABO SIGUIENDO METODOS CONVENCIONALES, TALES COMO HIDROGENACION CATALITICA, O CON HIDRUROS TALES COMO BOROHIDRURO SODICO. EL COMPUESTO OBTENIDO SE PUEDE RESOLVER EN SUS ANTIPODAS OPTICOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES PULMONARES.
ES513109A 1980-07-09 1982-06-15 "procedimiento de preparacion de derivados de 1-fenil-1-hidroxi-etilamina". Granted ES513109A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8022439 1980-07-09
GB8116441 1981-05-29

Publications (2)

Publication Number Publication Date
ES8304534A1 true ES8304534A1 (es) 1983-03-01
ES513109A0 ES513109A0 (es) 1983-03-01

Family

ID=26276161

Family Applications (3)

Application Number Title Priority Date Filing Date
ES503768A Expired ES8300678A1 (es) 1980-07-09 1981-07-08 Procedimiento de preparacion de derivados de 1-fenil-1-hi- droxi-etilamina
ES513109A Granted ES513109A0 (es) 1980-07-09 1982-06-15 "procedimiento de preparacion de derivados de 1-fenil-1-hidroxi-etilamina".
ES513108A Expired ES8304072A1 (es) 1980-07-09 1982-06-15 "procedimiento de preparacion de derivados de 1-fenil-1-hidroxi-etilamina".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES503768A Expired ES8300678A1 (es) 1980-07-09 1981-07-08 Procedimiento de preparacion de derivados de 1-fenil-1-hi- droxi-etilamina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES513108A Expired ES8304072A1 (es) 1980-07-09 1982-06-15 "procedimiento de preparacion de derivados de 1-fenil-1-hidroxi-etilamina".

Country Status (29)

Country Link
US (2) US4419364A (es)
EP (1) EP0043807B1 (es)
KR (3) KR850000301B1 (es)
AT (1) ATE7689T1 (es)
AU (1) AU539976B2 (es)
CA (1) CA1180021A (es)
CS (1) CS221845B2 (es)
CY (1) CY1273A (es)
DD (1) DD202001A5 (es)
DE (1) DE3163871D1 (es)
DK (1) DK157678C (es)
ES (3) ES8300678A1 (es)
FI (1) FI73666C (es)
GR (1) GR74291B (es)
HK (1) HK5385A (es)
HU (2) HU184959B (es)
IE (1) IE51373B1 (es)
IS (1) IS1262B6 (es)
LU (1) LU88304I2 (es)
MX (1) MX9203239A (es)
MY (1) MY8700026A (es)
NO (2) NO152130C (es)
NZ (1) NZ197628A (es)
PH (2) PH16535A (es)
PL (1) PL128513B1 (es)
PT (1) PT73336B (es)
SG (1) SG79784G (es)
SU (1) SU1128830A3 (es)
YU (3) YU42116B (es)

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SE8904064D0 (sv) * 1989-12-01 1989-12-01 Astra Ab Improved method of preparing an intermediate for the manufacture of bambuterol
SE9000948D0 (sv) 1990-03-16 1990-03-16 Draco Ab New use
US5830422A (en) * 1995-06-23 1998-11-03 Ormiston Mining And Smelting Co. Ltd. Method for production of sodium bicarbonate, sodium carbonate and ammonium sulfate from sodium sulfate
CA2247953A1 (en) * 1996-01-29 1997-07-31 E. Charles Pesterfield Jr. Method of treating undesired uterine contractions using optically pure r- or rr-isomers of adrenergic beta-2 agonists
SE9604752D0 (sv) * 1996-12-20 1996-12-20 Astra Ab Formulation and use
KR20030085658A (ko) * 2002-04-30 2003-11-07 한올제약주식회사 밤부테롤의 개선된 합성방법
US7495028B2 (en) * 2002-08-08 2009-02-24 Wen Tan R-bambuterol, its preparation and therapeutic uses
DE60228764D1 (de) * 2002-08-08 2008-10-16 Wen Tan R-bambuterol, seine herstellung und therapeutische verwendungen
US7825147B2 (en) * 2003-08-29 2010-11-02 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-IV
US20070259874A1 (en) * 2003-11-26 2007-11-08 Palle Venkata P Phosphodiesterase Inhibitors
WO2006081986A1 (en) * 2005-02-07 2006-08-10 F.Hoffmann-La Roche Ag Bambuterol and integrin inhibitor combination
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
CA2626612A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
US20090054382A1 (en) * 2005-10-19 2009-02-26 Abhijit Ray Compositions of phosphodiesterase type iv inhibitors
CL2007002427A1 (es) 2006-08-22 2008-03-14 Ranbaxy Lab Ltd Compuestos derivados heterociclicos, inhibidores de metaloproteinasa de matriz; proceso de preparacion; composicion farmaceutica, util para el tratamiento o profilaxis de enfermedades inflamatorias o desordenes autoinmunes.
US20100029728A1 (en) * 2006-09-22 2010-02-04 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
US20110021473A1 (en) * 2006-09-22 2011-01-27 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type-iv
EP1958947A1 (en) 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
ATE545417T1 (de) * 2007-03-14 2012-03-15 Ranbaxy Lab Ltd Pyrazoloä3,4-büpyridin-derivate als phosphodiesterasehemmer
WO2008111009A1 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
JP2013537533A (ja) 2010-07-30 2013-10-03 ランバクシー ラボラトリーズ リミテッド マトリックスメタロプロテイナーゼ阻害剤
SG188642A1 (en) 2010-09-24 2013-05-31 Ranbaxy Lab Ltd Matrix metalloproteinase inhibitors
EP2925725B1 (en) 2012-12-03 2016-11-09 Pfizer Inc. Novel selective androgen receptor modulators
WO2014108449A1 (en) 2013-01-08 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
CN104557614B (zh) * 2014-12-15 2017-01-04 广东东阳光药业有限公司 一种胺的还原方法
CN105622461B (zh) * 2016-01-29 2018-06-19 华南理工大学 一种化合物及其制备方法与应用
CN105859589B (zh) * 2016-04-05 2018-09-28 深圳市康立生生物科技有限公司 一种制备班布特罗杂质c的方法
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
CN109942462B (zh) * 2019-03-06 2022-01-14 宏冠生物药业有限公司 一种盐酸班布特罗的合成工艺
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Family Cites Families (30)

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SE178032C1 (es) 1961-01-01
DE1643488U (de) 1949-11-28 1952-09-11 G E Hilge Fa Brutgeraet.
DK85789C (da) 1955-07-05 1958-06-30 Cilag Ag Fremgangsmåde til fremstilling af d,1- eller 1-isopropyl-aminometyl-(3,4-dihydroksy-fenyl)-karbinol eller salte deraf.
DE1768167U (de) 1958-04-02 1958-06-04 Artur O Herrmann Warngeraet bei strassenhindernissen.
DE1275069B (de) 1960-02-15 1968-08-14 Boehringer Sohn Ingelheim 1-(3', 5'-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoalkane und Verfahren zu ihrer Herstellung
NL123439C (es) 1961-09-14
FR1324857A (fr) * 1962-06-14 1963-04-19 Chemie Linz Ag Procédé pour la préparation de dérivés de la phényléthanolamine
GB1141606A (en) 1965-04-12 1969-01-29 Rech S Et D Applic Scient Et M Improvements in alkyl ethers of substituted phenylaminoethanols
DE1543372A1 (de) 1966-10-18 1971-04-01 Boehringer Sohn Ingelheim Verfahren zur Herstellung von o-substituierten 3,4-Dioxyphenylalkanolaminen
SE335359B (es) 1966-10-19 1971-05-24 Draco Ab
NO132866C (es) 1966-10-19 1976-01-21 Draco Ab
SE358633B (es) 1966-10-19 1973-08-06 Draco Ab
US3937838A (en) * 1966-10-19 1976-02-10 Aktiebolaget Draco Orally active bronchospasmolytic compounds and their preparation
FR6087M (es) 1967-01-10 1968-06-04
SE369299B (es) 1967-10-18 1974-08-19 Draco Ab
SE338324B (es) 1967-12-19 1971-09-06 Haessle Ab
GB1298771A (en) 1969-04-01 1972-12-06 Sterling Drug Inc Carboxylic esters of hydroxyphenylalkanolamines
AT294046B (de) 1969-07-08 1971-11-10 Chemie Linz Ag Verfahren zur Herstellung des N,N'-Bis[2-(3',4'-dihydroxyphenyl)-2-hydroxyäthyl]-hexamethylendiamins, seiner optisch aktiven Formen und der Salze derselben
US3657319A (en) * 1970-05-05 1972-04-18 Smith Kline French Lab Alpha-aminoalkyl-4-hydroxy-3-carboalkoxyaminobenzyl alcohols
NO126437B (es) 1970-08-05 1973-02-05 Draco Ab
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CH550771A (de) 1970-10-30 1974-06-28 Hoffmann La Roche Verfahren zur herstellung von phenaethylaminderivaten.
US3876679A (en) 1970-12-09 1975-04-08 Aldrich Chem Co Inc Di-substituted phenethylcarbamic acid esters
FI55988C (fi) 1971-10-19 1979-11-12 Klinge Co Chem Pharm Fab Foerfarande foer framstaellning av terapeutiskt anvaendbara o-acylfenoletanolaminer
US4011258A (en) 1973-06-21 1977-03-08 Aktiebolaget Draco Orally active bronchospasmolytic compounds
FI56673C (fi) 1974-03-29 1981-02-04 Huhtamaeki Yhthymae Oy Nytt foerfarande foer framstaellning av alfa-tert-bytylaminometyl-4-hydroxy-m-xylen-alfa1 alfa3-diol
JPS556625B2 (es) 1974-05-16 1980-02-18
US4063025A (en) * 1975-02-05 1977-12-13 Yamanouchi Pharmaceutical Co., Ltd. 4-Substituted amino-α-aminomethylbenzyl alcohol derivatives
SE7510988L (sv) 1975-10-01 1977-04-02 Draco Ab Nya farmaceutiskt aktiva foreningar
DE2710997C3 (de) * 1977-03-14 1980-08-14 Dr. Karl Thomae Gmbh, 7950 Biberach 4-Alkoxy carbonylamino-phenyläthanolamine, deren Herstellung und deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CA1180021A (en) 1984-12-27
AU7261881A (en) 1982-01-14
KR850002740A (ko) 1985-05-15
ES503768A0 (es) 1982-11-01
ES8300678A1 (es) 1982-11-01
DK303481A (da) 1982-01-10
KR850002741A (ko) 1985-05-15
IS1262B6 (is) 1987-03-27
GR74291B (es) 1984-06-21
NO152130C (no) 1985-08-07
HK5385A (en) 1985-01-25
HU184959B (en) 1984-11-28
EP0043807B1 (en) 1984-05-30
DK157678B (da) 1990-02-05
FI73666C (fi) 1987-11-09
EP0043807A3 (en) 1982-09-22
HU187611B (en) 1986-02-28
NZ197628A (en) 1985-07-12
YU42116B (en) 1988-04-30
EP0043807A2 (en) 1982-01-13
US4451663A (en) 1984-05-29
YU43168B (en) 1989-04-30
PH16535A (en) 1983-11-10
MX9203239A (es) 1992-07-01
KR850000870B1 (ko) 1985-06-22
YU86483A (en) 1983-12-31
ES513108A0 (es) 1983-02-16
SG79784G (en) 1985-04-26
LU88304I2 (fr) 1994-05-04
PT73336B (en) 1983-09-01
MY8700026A (en) 1987-12-31
KR850000301B1 (ko) 1985-03-18
YU86383A (en) 1983-12-31
IE51373B1 (en) 1986-12-10
NO812311L (no) 1982-01-11
NO1996008I1 (no) 1996-06-27
YU170481A (en) 1983-12-31
CS221845B2 (en) 1983-04-29
DD202001A5 (de) 1983-08-24
PL232108A1 (es) 1982-08-02
PT73336A (en) 1981-08-01
SU1128830A3 (ru) 1984-12-07
ATE7689T1 (de) 1984-06-15
US4419364A (en) 1983-12-06
IE811522L (en) 1982-01-09
AU539976B2 (en) 1984-10-25
NO152130B (no) 1985-04-29
DE3163871D1 (en) 1984-07-05
FI812158L (fi) 1982-01-10
ES8304072A1 (es) 1983-02-16
DK157678C (da) 1990-06-18
FI73666B (fi) 1987-07-31
CY1273A (en) 1985-03-08
KR850000871B1 (ko) 1985-06-22
YU43169B (en) 1989-04-30
ES513109A0 (es) 1983-03-01
IS2657A7 (is) 1982-01-10
PH19447A (en) 1986-04-18
KR830006174A (ko) 1983-09-20
PL128513B1 (en) 1984-02-29

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