ES2002717A6 - Procedimiento para la preparacion de feniletanolaminotetralinas de actividad lipolitica - Google Patents

Procedimiento para la preparacion de feniletanolaminotetralinas de actividad lipolitica

Info

Publication number
ES2002717A6
ES2002717A6 ES868600121A ES8600121A ES2002717A6 ES 2002717 A6 ES2002717 A6 ES 2002717A6 ES 868600121 A ES868600121 A ES 868600121A ES 8600121 A ES8600121 A ES 8600121A ES 2002717 A6 ES2002717 A6 ES 2002717A6
Authority
ES
Spain
Prior art keywords
group
hydrogen
aminotetralines
phenylethanol
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES868600121A
Other languages
English (en)
Inventor
Roberto Cecchi
Robert Boigegrain
Alberto Bianchetti
Elena Poggesi
Tiziano Croci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8510559A external-priority patent/FR2584712B1/fr
Priority claimed from FR8606626A external-priority patent/FR2598410B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to ES868600121A priority Critical patent/ES2002717A6/es
Publication of ES2002717A6 publication Critical patent/ES2002717A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE FENILETANOLAMINOTETRALINAS DE ACTIVIDAD LIPOLITICA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA II FORMULA EN LA QUE <X> ES EL HIDROGENO, HALOGENO, UN GRUPO TRIFLUORO METILO O UN GRUPO ALQUILO INFERIOR, UNO DE LOS Z'' Y Z'''' ES EL HIDROGENO Y EL OTRO ES UN GRUPO HIDROXI, O BIEN Z'' Y Z'''' JUNTOS FORMAN UN GRUPO OXO; UNO DE LOS Y'' Y Y'''' ES EL HIDROGENO Y OTRO ES UN HALOGENO ELEGIDO ENTRE EL CLORO, EL BROMO Y EL YODO O UN GRUPO AMINO O BIEN Y'' E Y'''' JUNTOS, FORMAN UN ATOMO DE OXIGENO EPOXIDICO; CON UNA TETRALINA CUYOS SUSTITUTIVOS HIDROXI Y CARBOXI EVENTUALES ESTAN EVENTUALMENTE PROTEGIDOS DE FORMULA III ANTERIORMENTE SEÑALADA. EN LA QUE W'' Y W'''' ES EL HIDROGENO Y EL OTRO ES UN GRUPO AMINO O BIEN W'' Y W'''' JUNTOS, UN GRUPO OXO; PRODUCIENDOSE LA REACCION CUANDO POR LO MENOS ESTA PRESENTE UN GRUPO OXO EN UNO DE LOS COMPUESTOS II Y III EN PRESENCIA DE UN AGENTE REDUCTOR; SE SEPARAN EVENTUALMENTE LOS ESTEROISOMEROS, SE ELIMINAN LOS GRUPOS PROTECTORES Y SE TRANSFORMA EL PRODUCTO OBTENIDO EN SUS SALES FARMACEUTICAMENTE ACEPTABLES.
ES868600121A 1985-07-10 1986-07-04 Procedimiento para la preparacion de feniletanolaminotetralinas de actividad lipolitica Expired - Lifetime ES2002717A6 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES868600121A ES2002717A6 (es) 1985-07-10 1986-07-04 Procedimiento para la preparacion de feniletanolaminotetralinas de actividad lipolitica

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8510559A FR2584712B1 (fr) 1985-07-10 1985-07-10 Phenylethanolamines a activite lipolytique, un procede pour leur preparation et compositions pharmaceutiques en contenant
FR8606626A FR2598410B1 (fr) 1986-05-07 1986-05-07 Phenylethanolamines optiquement actives, un procede pour leur preparation et compositions pharmaceutiques en contenant
ES868600121A ES2002717A6 (es) 1985-07-10 1986-07-04 Procedimiento para la preparacion de feniletanolaminotetralinas de actividad lipolitica

Publications (1)

Publication Number Publication Date
ES2002717A6 true ES2002717A6 (es) 1992-04-16

Family

ID=26224609

Family Applications (1)

Application Number Title Priority Date Filing Date
ES868600121A Expired - Lifetime ES2002717A6 (es) 1985-07-10 1986-07-04 Procedimiento para la preparacion de feniletanolaminotetralinas de actividad lipolitica

Country Status (18)

Country Link
US (1) US4707497A (es)
EP (1) EP0211721B1 (es)
JP (1) JPS6263549A (es)
KR (1) KR940007739B1 (es)
AR (1) AR241014A1 (es)
AT (1) ATE46900T1 (es)
AU (1) AU596976B2 (es)
CA (1) CA1260493A (es)
DE (1) DE3666036D1 (es)
DK (1) DK167353B1 (es)
ES (1) ES2002717A6 (es)
FI (1) FI85692C (es)
GR (1) GR861764B (es)
IE (1) IE59399B1 (es)
IL (1) IL79323A (es)
NO (1) NO165190C (es)
NZ (1) NZ216793A (es)
PT (1) PT82930B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3623941A1 (de) * 1986-07-16 1988-01-28 Bayer Ag Substituierte amino-5,6,7,8-tetrahydronaphthyl-oxyessigsaeuren, verfahren zu deren herstellung sowie die verwendung als arzneimittel
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
US5153225A (en) * 1986-12-10 1992-10-06 Bayer Aktiengesellschaft Substituted basic 2-aminotetralin in pharmaceuticals
IT1199339B (it) * 1986-12-23 1988-12-30 Sigma Tau Ind Farmaceuti N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono
FR2629453B1 (fr) * 1988-03-30 1990-10-05 Midy Spa Procede pour la preparation de phenylethanolaminotetralines
FR2632636B1 (fr) * 1988-06-14 1991-03-22 Midy Spa Procede pour la preparation de phenylethanolaminotetralines
US5235103A (en) * 1987-08-12 1993-08-10 Sanofi Process for the preparation of phenylethanolaminotetralins
US5198586A (en) * 1987-08-12 1993-03-30 Sanofi Process for the preparation of phenylethanolaminotetralins
FR2619379B1 (fr) * 1987-08-12 1990-01-12 Midy Spa Procede pour la o-alkylation de n-(hydroxy) aralkyl-phenylethanolamines
FR2619378B1 (fr) * 1987-08-12 1989-12-15 Midy Spa Procede pour la preparation de phenylethanolaminotetralines
FR2632637B1 (fr) * 1988-06-14 1990-10-12 Midy Spa Ethers de la 2-amino-7-hydroxytetraline
EP0303545B1 (fr) * 1987-08-12 1992-06-17 Elf Sanofi Procédé pour la préparation de phényléthanolaminotétralines
DE3852589T2 (de) * 1987-08-12 1995-08-10 Sanofi Sa Verfahren zur O-Alkylierung von N-(Hydroxy)aralkylphenylethanolamin.
FR2619718B1 (fr) * 1987-09-02 1991-07-12 Medibrevex Nouvelles formes galeniques de beta-2-mimetiques pour administration par voie per- et sublinguale
CA1331191C (en) * 1988-03-25 1994-08-02 Bengt Ronny Andersson Therapeutically useful tetralin derivatives
US5202466A (en) * 1988-06-14 1993-04-13 Sanofi 2-amino-7-hydroxytetraline ethers
FR2643076B1 (fr) * 1989-02-14 1991-06-21 Midy Spa Carboxyalkyl-ethers de la 2-amino-7-hydroxytetraline
FR2648042B1 (fr) * 1989-06-13 1994-06-10 Midy Spa Utilisation de phenylethanolaminotetralines pour la preparation de medicaments pour le traitement des affections oculaires
SE8901889D0 (sv) * 1989-05-26 1989-05-26 Astra Ab Novel 8-substituted-2-aminotetralines
IT1230931B (it) * 1989-06-27 1991-11-08 Chiesi Farma Spa Derivati di 2 ammino 1,2,3,4 tetraidronaftalene ad attivita' cardiovascolare, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
FR2653765B1 (fr) * 1989-10-31 1993-08-06 Midy Spa Procede pour la preparation enantioselective de 2-aminotetralines.
FR2656607B1 (fr) * 1989-12-29 1994-03-11 Midy Spa Phenylethanolaminomethyltetralines.
IE65511B1 (en) * 1989-12-29 1995-11-01 Sanofi Sa New phenylethanolaminomethyltetralins
FR2669821A1 (fr) * 1990-12-04 1992-06-05 Sanofi Sa Utilisation de phenylethanolaminotetralines pour la preparation de medicaments destines au traitement de la depression.
EP0499755A1 (fr) * 1991-02-18 1992-08-26 MIDY S.p.A. Nouvelles phényléthanolaminotétralines, procédé pour leur préparation, intermédiaires dans ce procédé et compositions pharmaceutiques les contenant
GB9107827D0 (en) * 1991-04-12 1991-05-29 Fujisawa Pharmaceutical Co New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
IL104567A (en) * 1992-02-03 1997-03-18 Fujisawa Pharmaceutical Co Ethanolamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
ATE163930T1 (de) * 1993-01-29 1998-03-15 American Cyanamid Co Aminocycloalkanobenzodioxole als beta-3 selektive adrenergische wirkstoffe
EP0627407A1 (fr) * 1993-05-28 1994-12-07 MIDY S.p.A. Acide (7S)-7-[(2R)-2(3-chlorophényl)-2-hydroxyéthylamino]-5,6,7,8-tétrahydronaphtalèn-2-yloxy acétique, ses sels pharmaceutiquement acceptables, à action agoniste bêta-3 adrénergique et compositions pharmaceutiques le contenant
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5776983A (en) * 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5491134A (en) * 1994-09-16 1996-02-13 Bristol-Myers Squibb Company Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
US6197993B1 (en) 1996-07-02 2001-03-06 Ono Pharmaceutical Co., Ltd. Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient
JP3909864B2 (ja) * 1995-07-26 2007-04-25 小野薬品工業株式会社 ナフチルオキシ酢酸誘導体およびそれらを有効成分として含有する薬剤
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
US6075040A (en) 1996-09-05 2000-06-13 Eli Lilly And Company Selective β3 adrenergic agonists
US5770615A (en) * 1996-04-04 1998-06-23 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
ATE215369T1 (de) 1996-09-05 2002-04-15 Lilly Co Eli Carbazolanaloge als selektive beta3-adrenergische agonisten
FR2758723B1 (fr) * 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
DE69940484D1 (de) * 1998-04-06 2009-04-09 Astellas Pharma Inc Verwendung von beta-3-adrenergen-Rezeptoren Agonisten in der Behandlung von Dysurie

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK254975A (da) * 1974-06-12 1975-12-13 Takeda Chemical Industries Ltd Fremgangsmade til fremstilling af aminotetralolforbindelser
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
EP0033789B1 (en) * 1980-01-30 1984-03-07 American Hospital Supply Corporation 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, its salts, and a process for preparation thereof

Also Published As

Publication number Publication date
DK167353B1 (da) 1993-10-18
NO862773L (no) 1987-01-12
FI85692C (fi) 1992-05-25
FI862907A (fi) 1987-01-11
AR241014A1 (es) 1991-04-30
NO862773D0 (no) 1986-07-09
DK328586A (da) 1987-01-11
GR861764B (en) 1986-11-10
KR870001151A (ko) 1987-03-11
ATE46900T1 (de) 1989-10-15
EP0211721A1 (fr) 1987-02-25
US4707497A (en) 1987-11-17
NZ216793A (en) 1990-05-28
IE59399B1 (en) 1994-02-23
NO165190C (no) 1991-01-09
FI85692B (fi) 1992-02-14
NO165190B (no) 1990-10-01
AR241014A2 (es) 1991-04-30
AU596976B2 (en) 1990-05-24
DK328586D0 (da) 1986-07-10
KR940007739B1 (ko) 1994-08-24
IL79323A (en) 1990-03-19
FI862907A0 (fi) 1986-07-10
JPS6263549A (ja) 1987-03-20
IL79323A0 (en) 1986-10-31
DE3666036D1 (en) 1989-11-09
CA1260493A (en) 1989-09-26
IE861820L (en) 1987-01-10
PT82930B (pt) 1989-01-30
JP5071581B2 (es) 1993-10-07
PT82930A (fr) 1986-08-01
EP0211721B1 (fr) 1989-10-04
AU5988986A (en) 1987-01-15

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