ES8400488A1 - Un procedimiento para la preparacion de la sustancia f.r.-48756 acido 1-(6-amino-9-h-purin-9-il)-1,3-didedoxo-3-(o-metil l-tirosilamino)-b-d-ribofuranuronico. - Google Patents

Un procedimiento para la preparacion de la sustancia f.r.-48756 acido 1-(6-amino-9-h-purin-9-il)-1,3-didedoxo-3-(o-metil l-tirosilamino)-b-d-ribofuranuronico.

Info

Publication number
ES8400488A1
ES8400488A1 ES514862A ES514862A ES8400488A1 ES 8400488 A1 ES8400488 A1 ES 8400488A1 ES 514862 A ES514862 A ES 514862A ES 514862 A ES514862 A ES 514862A ES 8400488 A1 ES8400488 A1 ES 8400488A1
Authority
ES
Spain
Prior art keywords
preparation
processes
new
acid derivatives
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514862A
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English (en)
Other versions
ES514862A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8400488A1 publication Critical patent/ES8400488A1/es
Publication of ES514862A0 publication Critical patent/ES514862A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE LA SUSTANCIA FR-48736, ACIDO 1-(6-AMINO-9H-PURIN-9-IL) -1,3-DIDESOXI-3- (3-METIL-L-TIROSILAMINO)-B-D RIBOFURANURONICO.CONSISTE EN CULTIVAR UNA CEPA PRODUCTORA DE FR-48736 PERTENECIENTE AL GENERO CHRYSOSPOSIUM EN UN MEDIO NUTRITUVO ACUOSO BAJO CONDICIONES AEROBIAS Y RECUPERAR LA SUSTANCIA FR-48736 O UNA SAL DE LA MISMA. SE OBTIENEN COMPUESTOS DE FORMULA GENERAL (I) EN QUE R1 ES UN GRUPO AMINO O AMINO PROTEGIDO; R2 ES AMINO O ACILAMINO Y R3 ES CARBOXI O UN GRUPO CARBOXI PROTEGIDO.
ES514862A 1981-08-10 1982-08-09 Un procedimiento para la preparacion de la sustancia f.r.-48756 acido 1-(6-amino-9-h-purin-9-il)-1,3-didedoxo-3-(o-metil l-tirosilamino)-b-d-ribofuranuronico. Granted ES514862A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8124352 1981-08-10

Publications (2)

Publication Number Publication Date
ES8400488A1 true ES8400488A1 (es) 1983-11-01
ES514862A0 ES514862A0 (es) 1983-11-01

Family

ID=10523827

Family Applications (3)

Application Number Title Priority Date Filing Date
ES514862A Granted ES514862A0 (es) 1981-08-10 1982-08-09 Un procedimiento para la preparacion de la sustancia f.r.-48756 acido 1-(6-amino-9-h-purin-9-il)-1,3-didedoxo-3-(o-metil l-tirosilamino)-b-d-ribofuranuronico.
ES521429A Granted ES521429A0 (es) 1981-08-10 1983-04-13 Un procedimiento para la preparacion de derivados del acido tetrahidrofurancarboxilico.
ES521430A Granted ES521430A0 (es) 1981-08-10 1983-04-13 Un procedimiento para la preparacion de derivados del acido tetrahidrofurancarboxilico.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES521429A Granted ES521429A0 (es) 1981-08-10 1983-04-13 Un procedimiento para la preparacion de derivados del acido tetrahidrofurancarboxilico.
ES521430A Granted ES521430A0 (es) 1981-08-10 1983-04-13 Un procedimiento para la preparacion de derivados del acido tetrahidrofurancarboxilico.

Country Status (7)

Country Link
US (1) US4479942A (es)
EP (1) EP0071926B1 (es)
JP (1) JPS5843994A (es)
KR (1) KR840001173A (es)
DE (1) DE3273629D1 (es)
DK (1) DK357782A (es)
ES (3) ES514862A0 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6137799A (ja) * 1984-07-31 1986-02-22 Suntory Ltd エリプチシン誘導体およびその製造法
US4738954A (en) * 1985-11-06 1988-04-19 Warner-Lambert Company Novel N6 -substituted-5'-oxidized adenosine analogs
US4868160A (en) * 1985-11-06 1989-09-19 Warner-Lambert Company Method of treating psychosis using N6 -substituted -5'-oxidized adenosine analogs
US6175008B1 (en) 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical preparations containing them
US5175266A (en) * 1991-04-19 1992-12-29 Triplex Pharmaceutical Corporation Nucleosides and oligonucleosides with a phosphate-free internucleoside backbone and process for preparing the same
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
JP2002533470A (ja) 1998-12-23 2002-10-08 シャイアー・バイオケム・インコーポレイテッド 抗ウイルス性ヌクレオシド類似体
US6593466B1 (en) * 1999-07-07 2003-07-15 Isis Pharmaceuticals, Inc. Guanidinium functionalized nucleotides and precursors thereof
WO2002040481A2 (en) * 2000-11-20 2002-05-23 Millennium Pharmaceuticals, Inc. Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions and method of use thereof
US20030114362A1 (en) * 2001-06-08 2003-06-19 Novaspin Biotech Gmbh Penta-or tetrapeptide binding to somatostatin receptors and the use of the same
CN113637042A (zh) * 2021-08-24 2021-11-12 杭州中非生物科技有限公司 蚕虫草活性成分的制备工艺及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852506A (en) * 1955-10-31 1958-09-16 American Cyanamid Co Method of preparing aminodeoxyglycosidopurines
US2985564A (en) * 1957-09-03 1961-05-23 American Cyanamid Co Production of puromycin
US4224438A (en) * 1970-07-14 1980-09-23 Boehringer Mannheim Gmbh Adenosine-5'-carboxylic acid amides
DE2034785A1 (de) * 1970-07-14 1972-01-20 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof Adenosin 5 carbonsäurederivate
US3868451A (en) * 1971-03-30 1975-02-25 Abbott Lab Adenosine-5{40 -esters in treating angina pectoris
US3825541A (en) * 1972-01-26 1974-07-23 Univ Minnesota (+-)-9-(beta-(3-alpha-amino-2alpha-hydroxy)cyclopentyl)-6-substituted-purines and derivatives thereof
US4205164A (en) * 1979-03-02 1980-05-27 Eli Lilly And Company Antibiotic A201C, A201D and A201E

Also Published As

Publication number Publication date
ES8405005A1 (es) 1984-05-16
ES514862A0 (es) 1983-11-01
ES8405006A1 (es) 1984-05-16
DK357782A (da) 1983-02-11
JPS5843994A (ja) 1983-03-14
EP0071926B1 (en) 1986-10-08
DE3273629D1 (en) 1986-11-13
US4479942A (en) 1984-10-30
ES521429A0 (es) 1984-05-16
EP0071926A1 (en) 1983-02-16
ES521430A0 (es) 1984-05-16
KR840001173A (ko) 1984-03-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405