ES8403858A1 - Procedimiento para la preparacion de dipeptidos carboxialquilicos. - Google Patents
Procedimiento para la preparacion de dipeptidos carboxialquilicos.Info
- Publication number
- ES8403858A1 ES8403858A1 ES520261A ES520261A ES8403858A1 ES 8403858 A1 ES8403858 A1 ES 8403858A1 ES 520261 A ES520261 A ES 520261A ES 520261 A ES520261 A ES 520261A ES 8403858 A1 ES8403858 A1 ES 8403858A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- processes
- production
- compositions containing
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DIPEPTIDOS CARBOXIALQUILICOS Y DE SUS ESTERES Y SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, R1, R2, R3, R4 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE CONDENSACION DE UN AMINOACIDO, DE FORMULA (II), CON UN AMINOACIDO DE FORMULA (III), EN LAS QUE PR ES UN GRUPO HIDROXI LIBRE O PROTEGIDO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN PRESENCIA DE UN AGENTE CONDENSADOR, EN METILONITRILO, SEGUIDA DE LA EVENTUAL ELIMINACION DE LOS GRUPOS PROTECTORES.ESTOS COMPUESTOSTIENEN APLICACIONES PARA EL TRATAMIENTO DE FALLOS CARDIACOS CONGESTIVOS Y GLAUCOMA, COMO AGENTES ANTIHIPERTENSIVOS.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/355,639 US4431645A (en) | 1982-03-08 | 1982-03-08 | Antihypertensive agents |
US06/355,638 US4431644A (en) | 1982-03-08 | 1982-03-08 | Antihypertensive agents |
US36053282A | 1982-03-22 | 1982-03-22 | |
ZA83362A ZA83362B (en) | 1982-03-08 | 1983-01-19 | Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8403858A1 true ES8403858A1 (es) | 1984-04-01 |
ES520261A0 ES520261A0 (es) | 1984-04-01 |
Family
ID=27502886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES520261A Granted ES520261A0 (es) | 1982-03-08 | 1983-03-03 | Procedimiento para la preparacion de dipeptidos carboxialquilicos. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0088350B1 (es) |
AU (1) | AU557795B2 (es) |
DE (1) | DE3360065D1 (es) |
DK (1) | DK110183A (es) |
ES (1) | ES520261A0 (es) |
FI (1) | FI830752L (es) |
GB (1) | GB2117777B (es) |
GR (1) | GR77940B (es) |
HU (1) | HU195520B (es) |
IE (1) | IE54684B1 (es) |
IL (1) | IL68028A0 (es) |
NO (1) | NO830737L (es) |
NZ (1) | NZ203461A (es) |
OA (1) | OA07334A (es) |
PT (1) | PT76332B (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3211676A1 (de) * | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
US4681886A (en) * | 1982-04-30 | 1987-07-21 | E. R. Squibb & Sons, Inc. | Substituted 4-phenoxy or 4-phenylthio prolines |
DE3242151A1 (de) * | 1982-11-13 | 1984-05-17 | Hoechst Ag, 6230 Frankfurt | Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
FI841052A (fi) * | 1983-03-16 | 1984-09-17 | Usv Pharma Corp | Foereningar foer behandling av blodtryckssjukdomar. |
JPS6034993A (ja) * | 1983-05-23 | 1985-02-22 | ユーエスヴイー フアーマシユーテイカル コーポレーシヨン | 高血圧治療用化合物 |
US4888424A (en) * | 1984-02-27 | 1989-12-19 | E. R. Squibb & Sons, Inc. | ACE-diuretics |
US4536501A (en) * | 1984-03-30 | 1985-08-20 | E. R. Squibb & Sons, Inc. | Substituted 4-phenoxy or 4-phenylthio prolines |
GB8422165D0 (en) * | 1984-09-01 | 1984-10-03 | Wellcome Found | Compounds |
AU578489B2 (en) * | 1984-09-12 | 1988-10-27 | Rorer Pharmaceutical Corporation | Proline derivatives |
US4746676A (en) * | 1984-09-12 | 1988-05-24 | Rorer Pharmaceutical Corporation | Carboxyalkyl dipeptide compounds |
US4556655A (en) * | 1984-09-24 | 1985-12-03 | Schering Corporation | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
EP0190852A3 (en) * | 1985-01-31 | 1988-11-02 | Ajinomoto Co., Inc. | Dipeptide derivatives and antihypertensive drugs containing them |
DE3582595D1 (de) * | 1985-09-16 | 1991-05-23 | Schering Corp | Antihypertensive mittel, deren pharmazeutische zusammensetzungen und verfahren zur herstellung von mitteln und zusammensetzungen. |
AU581929B2 (en) * | 1985-09-16 | 1989-03-09 | Schering Corporation | Antihypertensive agents, pharmaceutical compositions containing them and processes for the preparation of the agents and compositions |
US4803261A (en) * | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
US4897445A (en) * | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
US5059653A (en) * | 1988-03-04 | 1991-10-22 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
DK167813B1 (da) * | 1989-12-07 | 1993-12-20 | Carlbiotech Ltd As | Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
DK53291D0 (da) * | 1991-03-25 | 1991-03-25 | Carlbiotech Ltd As | Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser |
US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US7056935B2 (en) | 1995-06-07 | 2006-06-06 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US6218424B1 (en) | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
US6274602B1 (en) | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
US6271244B1 (en) | 1998-06-03 | 2001-08-07 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses |
US6187784B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Pipecolic acid derivative hair growth compositions and uses |
US6187796B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Sulfone hair growth compositions and uses |
US20010049381A1 (en) | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6429215B1 (en) | 1998-06-03 | 2002-08-06 | Gpi Nil Holdings, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
CA2334204A1 (en) | 1998-06-03 | 1999-12-09 | Gpi Nil Holdings, Inc. | Heterocyclic ester and amide hair growth compositions and uses |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
US6172087B1 (en) | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
SK18302000A3 (sk) | 1998-06-03 | 2001-06-11 | Gpi Nil Holdings, Inc. | N-viazané sulfónamidy n-heterocyklických karboxylových kyselín a izosterov karboxylových kyselín, farmaceutický prostriedok s ich obsahom a ich použitie |
US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6506788B1 (en) | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6384056B1 (en) | 1998-08-14 | 2002-05-07 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters or ketones for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6335348B1 (en) | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
US6333340B1 (en) | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
WO2007078990A2 (en) | 2005-12-23 | 2007-07-12 | Zealand Pharma A/S | Modified lysine-mimetic compounds |
DK3618847T3 (da) | 2017-05-05 | 2021-05-25 | Boston Medical Ct Corp | GAP-junction-modulatorer af intercellulær kommunikation og deres anvendelse til behandling af diabetisk øjensygdom |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
EP0050800B2 (en) * | 1980-10-23 | 1995-06-07 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
EP0065301A1 (en) * | 1981-05-18 | 1982-11-24 | Merck & Co. Inc. | Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same |
-
1983
- 1983-03-02 EP EP83102014A patent/EP0088350B1/en not_active Expired
- 1983-03-02 DE DE8383102014T patent/DE3360065D1/de not_active Expired
- 1983-03-03 ES ES520261A patent/ES520261A0/es active Granted
- 1983-03-03 NZ NZ203461A patent/NZ203461A/en unknown
- 1983-03-03 OA OA57928A patent/OA07334A/xx unknown
- 1983-03-03 NO NO830737A patent/NO830737L/no unknown
- 1983-03-03 GR GR70663A patent/GR77940B/el unknown
- 1983-03-03 AU AU12035/83A patent/AU557795B2/en not_active Ceased
- 1983-03-03 GB GB08305837A patent/GB2117777B/en not_active Expired
- 1983-03-03 IL IL68028A patent/IL68028A0/xx unknown
- 1983-03-03 PT PT76332A patent/PT76332B/pt unknown
- 1983-03-04 DK DK110183A patent/DK110183A/da not_active Application Discontinuation
- 1983-03-04 IE IE479/83A patent/IE54684B1/en unknown
- 1983-03-07 HU HU83781A patent/HU195520B/hu unknown
- 1983-03-07 FI FI830752A patent/FI830752L/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ203461A (en) | 1986-12-05 |
IL68028A0 (en) | 1983-06-15 |
HU195520B (en) | 1988-05-30 |
NO830737L (no) | 1983-09-09 |
AU1203583A (en) | 1983-09-15 |
GB8305837D0 (en) | 1983-04-07 |
EP0088350B1 (en) | 1985-02-20 |
IE54684B1 (en) | 1990-01-03 |
GR77940B (es) | 1984-09-25 |
DK110183A (da) | 1983-09-09 |
PT76332A (en) | 1983-04-01 |
DE3360065D1 (en) | 1985-03-28 |
GB2117777A (en) | 1983-10-19 |
PT76332B (en) | 1986-02-03 |
OA07334A (fr) | 1984-08-31 |
IE830479L (en) | 1983-09-08 |
FI830752L (fi) | 1983-09-09 |
EP0088350A1 (en) | 1983-09-14 |
GB2117777B (en) | 1985-06-26 |
DK110183D0 (da) | 1983-03-04 |
AU557795B2 (en) | 1987-01-08 |
FI830752A0 (fi) | 1983-03-07 |
ES520261A0 (es) | 1984-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971201 |