DK110183A - Carboxyalkyldipeptider, fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende disse - Google Patents

Carboxyalkyldipeptider, fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende disse Download PDF

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Publication number
DK110183A
DK110183A DK110183A DK110183A DK110183A DK 110183 A DK110183 A DK 110183A DK 110183 A DK110183 A DK 110183A DK 110183 A DK110183 A DK 110183A DK 110183 A DK110183 A DK 110183A
Authority
DK
Denmark
Prior art keywords
carboxyal
tides
procedures
preparation
pharmaceutical preparations
Prior art date
Application number
DK110183A
Other languages
English (en)
Other versions
DK110183D0 (da
Inventor
Elizabeth Melva Smith
Joseph Theodore Witkowski
Ronald James Doll
Elijah Herman Gold
Bernard Ray Neustadt
Albert Solomon Yehaskel
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/355,638 external-priority patent/US4431644A/en
Priority claimed from US06/355,639 external-priority patent/US4431645A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of DK110183D0 publication Critical patent/DK110183D0/da
Publication of DK110183A publication Critical patent/DK110183A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK110183A 1982-03-08 1983-03-04 Carboxyalkyldipeptider, fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende disse DK110183A (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/355,638 US4431644A (en) 1982-03-08 1982-03-08 Antihypertensive agents
US06/355,639 US4431645A (en) 1982-03-08 1982-03-08 Antihypertensive agents
US36053282A 1982-03-22 1982-03-22
ZA83362A ZA83362B (en) 1982-03-08 1983-01-19 Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
DK110183D0 DK110183D0 (da) 1983-03-04
DK110183A true DK110183A (da) 1983-09-09

Family

ID=27502886

Family Applications (1)

Application Number Title Priority Date Filing Date
DK110183A DK110183A (da) 1982-03-08 1983-03-04 Carboxyalkyldipeptider, fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende disse

Country Status (15)

Country Link
EP (1) EP0088350B1 (da)
AU (1) AU557795B2 (da)
DE (1) DE3360065D1 (da)
DK (1) DK110183A (da)
ES (1) ES8403858A1 (da)
FI (1) FI830752L (da)
GB (1) GB2117777B (da)
GR (1) GR77940B (da)
HU (1) HU195520B (da)
IE (1) IE54684B1 (da)
IL (1) IL68028A0 (da)
NO (1) NO830737L (da)
NZ (1) NZ203461A (da)
OA (1) OA07334A (da)
PT (1) PT76332B (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US4681886A (en) * 1982-04-30 1987-07-21 E. R. Squibb & Sons, Inc. Substituted 4-phenoxy or 4-phenylthio prolines
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
ZA843899B (en) * 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension
US4888424A (en) * 1984-02-27 1989-12-19 E. R. Squibb & Sons, Inc. ACE-diuretics
US4536501A (en) * 1984-03-30 1985-08-20 E. R. Squibb & Sons, Inc. Substituted 4-phenoxy or 4-phenylthio prolines
GB8422165D0 (en) * 1984-09-01 1984-10-03 Wellcome Found Compounds
US4746676A (en) * 1984-09-12 1988-05-24 Rorer Pharmaceutical Corporation Carboxyalkyl dipeptide compounds
DE3588094T2 (de) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive Derivate
US4556655A (en) * 1984-09-24 1985-12-03 Schering Corporation Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity
EP0190852A3 (en) * 1985-01-31 1988-11-02 Ajinomoto Co., Inc. Dipeptide derivatives and antihypertensive drugs containing them
KR900009154B1 (ko) * 1985-09-16 1990-12-22 쉐링 코포레이션 고혈압 치료제, 이를 포함하는 약제학적 조성물 및 이들의 제조방법
AU581929B2 (en) * 1985-09-16 1989-03-09 Schering Corporation Antihypertensive agents, pharmaceutical compositions containing them and processes for the preparation of the agents and compositions
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
US4897445A (en) * 1986-06-27 1990-01-30 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
US5059653A (en) * 1988-03-04 1991-10-22 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
DK167813B1 (da) * 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
DK53291D0 (da) * 1991-03-25 1991-03-25 Carlbiotech Ltd As Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US6218424B1 (en) 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
EP1085853A1 (en) 1998-06-03 2001-03-28 GPI NIL Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
PL348661A1 (en) 1998-06-03 2002-06-03 Gpi Nil Holdings N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
UA96283C2 (uk) 2005-12-23 2011-10-25 Зіланд Фарма А/С Модифіковані міметики лізину
CN110709096B (zh) 2017-05-05 2023-10-31 泽兰德制药公司 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0065301A1 (en) * 1981-05-18 1982-11-24 Merck & Co. Inc. Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same

Also Published As

Publication number Publication date
NZ203461A (en) 1986-12-05
EP0088350A1 (en) 1983-09-14
FI830752A0 (fi) 1983-03-07
IE830479L (en) 1983-09-08
GB2117777A (en) 1983-10-19
PT76332B (en) 1986-02-03
ES520261A0 (es) 1984-04-01
FI830752L (fi) 1983-09-09
GB8305837D0 (en) 1983-04-07
OA07334A (fr) 1984-08-31
GR77940B (da) 1984-09-25
NO830737L (no) 1983-09-09
AU1203583A (en) 1983-09-15
ES8403858A1 (es) 1984-04-01
PT76332A (en) 1983-04-01
DK110183D0 (da) 1983-03-04
HU195520B (en) 1988-05-30
DE3360065D1 (en) 1985-03-28
EP0088350B1 (en) 1985-02-20
IE54684B1 (en) 1990-01-03
GB2117777B (en) 1985-06-26
AU557795B2 (en) 1987-01-08
IL68028A0 (en) 1983-06-15

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