ES8604970A1 - Procedimiento para la obtencion de compuestos de 2-heterociclil-alquilo inferior-2-penem - Google Patents
Procedimiento para la obtencion de compuestos de 2-heterociclil-alquilo inferior-2-penemInfo
- Publication number
- ES8604970A1 ES8604970A1 ES532212A ES532212A ES8604970A1 ES 8604970 A1 ES8604970 A1 ES 8604970A1 ES 532212 A ES532212 A ES 532212A ES 532212 A ES532212 A ES 532212A ES 8604970 A1 ES8604970 A1 ES 8604970A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- formula
- tetrazolylpropyl
- preparation
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- YXQJURQOHXBLOJ-XCGJVMPOSA-N (5r)-3-[2-(2h-tetrazol-5-yl)propyl]-4-thia-1-azabicyclo[3.2.0]hept-2-en-7-one Chemical class S([C@H]1N(C(C1)=O)C=1)C=1CC(C)C=1N=NNN=1 YXQJURQOHXBLOJ-XCGJVMPOSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE 2-HETEROCICLIL-ALQUILO INFERIOR-2-PENEM. CONSISTE EN CERRAR EL ANILLO DEL COMPUESTO ILIDA DE FORMULA (II) EN FORMA ESPONTANEA O POR CALENTAMIENTO DE 30 A 160JC, EN UN DISOLVENTE COMO HEXANO, BENCENO, TOLUENO U OTROS, PARA OBTENER COMPUESTOS DE 2-HETEROCICLIL-ALQUILO INFERIOR-2-PENEM DE FORMULA (I), DONDE R1 ES ALQUILO INFERIOR SUSTITUIDO POR HIDROXI O HIDROXI PROTEGIDO; R2 ES CARBOXILO O CARBOXILO FUNCIONALMENTE MODIFICADO; R3 ES UN RESTO AZAHETEROCICLICO MONOCICLICO INSATURADO ENLAZADO A TRAVES DE UN ATOMO DE NITROGENO DE ANILLO TERCIARIO CON EL RESTO -A-; Y A SIGNIFICA ALQUILO INFERIOR DE CADENA RECTA SUSTITUIDO POR ALQUILO INFERIOR. TIENEN APLICACIONES FARMACOLOGICAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH249083 | 1983-05-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532212A0 ES532212A0 (es) | 1986-02-16 |
| ES8604970A1 true ES8604970A1 (es) | 1986-02-16 |
Family
ID=4234969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532212A Expired ES8604970A1 (es) | 1983-05-06 | 1984-05-04 | Procedimiento para la obtencion de compuestos de 2-heterociclil-alquilo inferior-2-penem |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0125207A1 (es) |
| JP (1) | JPS6034970A (es) |
| KR (1) | KR840009107A (es) |
| AU (1) | AU566019B2 (es) |
| DK (1) | DK222284A (es) |
| ES (1) | ES8604970A1 (es) |
| FI (1) | FI841739A (es) |
| GR (1) | GR81605B (es) |
| IL (1) | IL71756A0 (es) |
| NO (1) | NO841788L (es) |
| NZ (1) | NZ208054A (es) |
| PH (1) | PH21606A (es) |
| PT (1) | PT78530B (es) |
| ZA (1) | ZA843345B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH21930A (en) * | 1982-11-16 | 1988-04-08 | Ciba Geigy Ag | 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof |
| GB8509180D0 (en) * | 1985-04-10 | 1985-05-15 | Erba Farmitalia | Penem derivatives |
| EP0252885A1 (de) * | 1986-07-10 | 1988-01-13 | Ciba-Geigy Ag | Bicyclische Thiaazaverbindungen |
| US4891369A (en) * | 1986-12-03 | 1990-01-02 | Taiho Pharmaceutical Company, Limited | 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof |
| ES2206557T3 (es) * | 1995-02-17 | 2004-05-16 | Daiichi Suntory Pharma Co., Ltd. | Derivados que penem y agente antimicrobiano que los contiene. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
| EP0042026B1 (de) * | 1978-02-02 | 1986-01-08 | Ciba-Geigy Ag | 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung |
| JPS5625110A (en) * | 1978-12-18 | 1981-03-10 | Bristol Myers Co | Antibacterial |
-
1984
- 1984-04-30 EP EP84810204A patent/EP0125207A1/de not_active Ceased
- 1984-05-02 PH PH30635A patent/PH21606A/en unknown
- 1984-05-02 FI FI841739A patent/FI841739A/fi not_active Application Discontinuation
- 1984-05-02 JP JP59087962A patent/JPS6034970A/ja active Pending
- 1984-05-03 PT PT78530A patent/PT78530B/pt unknown
- 1984-05-04 GR GR74602A patent/GR81605B/el unknown
- 1984-05-04 AU AU27703/84A patent/AU566019B2/en not_active Ceased
- 1984-05-04 NO NO841788A patent/NO841788L/no unknown
- 1984-05-04 ZA ZA843345A patent/ZA843345B/xx unknown
- 1984-05-04 ES ES532212A patent/ES8604970A1/es not_active Expired
- 1984-05-04 NZ NZ208054A patent/NZ208054A/en unknown
- 1984-05-04 IL IL71756A patent/IL71756A0/xx unknown
- 1984-05-04 KR KR1019840002451A patent/KR840009107A/ko not_active Application Discontinuation
- 1984-05-04 DK DK222284A patent/DK222284A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT78530A (en) | 1984-06-01 |
| NZ208054A (en) | 1987-01-23 |
| ES532212A0 (es) | 1986-02-16 |
| DK222284A (da) | 1984-11-07 |
| JPS6034970A (ja) | 1985-02-22 |
| AU2770384A (en) | 1984-11-08 |
| PT78530B (en) | 1986-09-15 |
| AU566019B2 (en) | 1987-10-08 |
| FI841739A (fi) | 1984-11-07 |
| DK222284D0 (da) | 1984-05-04 |
| KR840009107A (ko) | 1984-12-24 |
| FI841739A0 (fi) | 1984-05-02 |
| IL71756A0 (en) | 1984-09-30 |
| GR81605B (es) | 1984-12-11 |
| PH21606A (en) | 1987-12-11 |
| EP0125207A1 (de) | 1984-11-14 |
| ZA843345B (en) | 1984-12-24 |
| NO841788L (no) | 1984-11-07 |
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