ES480762A1 - Procedimiento para la preparacion de derivados de cefem. - Google Patents

Procedimiento para la preparacion de derivados de cefem.

Info

Publication number
ES480762A1
ES480762A1 ES480762A ES480762A ES480762A1 ES 480762 A1 ES480762 A1 ES 480762A1 ES 480762 A ES480762 A ES 480762A ES 480762 A ES480762 A ES 480762A ES 480762 A1 ES480762 A1 ES 480762A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
molecular weight
low molecular
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480762A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES480762A1 publication Critical patent/ES480762A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de derivados de cefem de la fórmula general I **(Fórmula)** Donde n significa 0 ó 1, A representa un grupo metilo o un grupo ¿CH2O-acilo con acilo de bajo peso molecular, Z significa oxígeno o =NOR, donde R es hidrógeno o alcohilo saturado o insaturado de bajo peso molecular y R1 significa hidrógeno o alcoxi de bajo peso molecular, así como sus sales y ésteres farmacológicamente compatibles, que se caracteriza porque se hacen reaccionar ácidos tiazolilcarboxílicos.
ES480762A 1978-05-26 1979-05-21 Procedimiento para la preparacion de derivados de cefem. Expired ES480762A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782822860 DE2822860A1 (de) 1978-05-26 1978-05-26 Cephemderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES480762A1 true ES480762A1 (es) 1979-11-16

Family

ID=6040152

Family Applications (1)

Application Number Title Priority Date Filing Date
ES480762A Expired ES480762A1 (es) 1978-05-26 1979-05-21 Procedimiento para la preparacion de derivados de cefem.

Country Status (11)

Country Link
US (1) US4282220A (es)
EP (1) EP0006146B1 (es)
JP (1) JPS54154785A (es)
AT (1) ATE1551T1 (es)
AU (1) AU4740979A (es)
CA (1) CA1132978A (es)
DE (2) DE2822860A1 (es)
ES (1) ES480762A1 (es)
FI (1) FI791649A7 (es)
IL (1) IL57394A0 (es)
ZA (1) ZA792571B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1592149A (en) * 1976-10-08 1981-07-01 Fujisawa Pharmaceutical Co 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
DE2914327A1 (de) * 1979-04-09 1980-10-30 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
ZA825194B (en) * 1981-08-03 1983-05-25 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
IE53429B1 (en) * 1981-08-03 1988-11-09 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
US4499088A (en) * 1983-01-04 1985-02-12 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
US4761409A (en) * 1984-08-16 1988-08-02 Sumitomo Pharmaceuticals Company, Limited Cephem derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne

Also Published As

Publication number Publication date
AU4740979A (en) 1979-11-29
EP0006146B1 (de) 1982-09-15
US4282220A (en) 1981-08-04
ATE1551T1 (de) 1982-09-15
CA1132978A (en) 1982-10-05
JPS54154785A (en) 1979-12-06
ZA792571B (en) 1980-06-25
FI791649A7 (fi) 1979-11-27
DE2963665D1 (en) 1982-11-04
DE2822860A1 (de) 1979-11-29
EP0006146A1 (de) 1980-01-09
IL57394A0 (en) 1979-09-30

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