ES8307822A1 - Procedimiento para la obtencion de acido 7b-acilamido-3-cefem-4-carboxilico. - Google Patents

Procedimiento para la obtencion de acido 7b-acilamido-3-cefem-4-carboxilico.

Info

Publication number
ES8307822A1
ES8307822A1 ES509956A ES509956A ES8307822A1 ES 8307822 A1 ES8307822 A1 ES 8307822A1 ES 509956 A ES509956 A ES 509956A ES 509956 A ES509956 A ES 509956A ES 8307822 A1 ES8307822 A1 ES 8307822A1
Authority
ES
Spain
Prior art keywords
group
integer
acylamido
cephem
conhso2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509956A
Other languages
English (en)
Other versions
ES509956A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES509956A0 publication Critical patent/ES509956A0/es
Publication of ES8307822A1 publication Critical patent/ES8307822A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDO 7~J-ACILAMIDO-3-CEFEM-4-CARBOXILICO. CONSISTE EN ACILAR EL GRUPO 7~J-AMINO EN UN COMPUESTO (II) MEDIANTE REACCION CON UN ACIDO CARBOXILICO (III), O CON UN DERIVADO DE ACIDO FUNCIONAL CAPAZ DE REACCION O CON UNA SAL DEL MISMO. SE OBTIENE EL COMPUESTO (I) DONDE R<1 ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO O UN GRUPO -CH<2-R<2, DONDE R<2 ES UN GRUPO HIDROXILO O MERCAPTO LIBRE ESTERIFICADO O ETERADO, O UN GRUPO AMONIO CUATERNARIO; R<3 ES HIDROGENO O ALCOXI; R<4 ES CARBOXILO O CARBOXILO PROTEGIDO.
ES509956A 1981-02-27 1982-02-26 Procedimiento para la obtencion de acido 7b-acilamido-3-cefem-4-carboxilico. Expired ES8307822A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH133581 1981-02-27
CH403681 1981-06-18
CH36882 1982-01-21

Publications (2)

Publication Number Publication Date
ES509956A0 ES509956A0 (es) 1983-08-16
ES8307822A1 true ES8307822A1 (es) 1983-08-16

Family

ID=27172045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509956A Expired ES8307822A1 (es) 1981-02-27 1982-02-26 Procedimiento para la obtencion de acido 7b-acilamido-3-cefem-4-carboxilico.

Country Status (10)

Country Link
EP (1) EP0059683A3 (es)
AU (1) AU8093482A (es)
DK (1) DK84982A (es)
ES (1) ES8307822A1 (es)
FI (1) FI820618L (es)
GB (1) GB2095238B (es)
GR (1) GR78230B (es)
IL (1) IL65108A0 (es)
NO (1) NO820618L (es)
PT (1) PT74498B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0096297B1 (de) * 1982-06-03 1988-06-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidinderivaten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2861767D1 (en) * 1977-07-18 1982-06-09 Ciba Geigy Ag Cephalosprin derivatives, process for their preparation and pharmaceutical compositions containing them
US4313945A (en) * 1978-11-23 1982-02-02 Ciba-Geigy Corporation 7-Thiazolyl-acetamido-cephem derivatives with terminal aminocarboxylic acid grouping
US4464366A (en) * 1979-12-19 1984-08-07 Ciba Geigy Corporation Cephem compounds having a terminal aminocarboxylic acid grouping and containing an azacyclyl(thio)ureido group

Also Published As

Publication number Publication date
EP0059683A2 (de) 1982-09-08
AU8093482A (en) 1982-09-02
PT74498A (de) 1982-03-01
GB2095238A (en) 1982-09-29
EP0059683A3 (de) 1982-12-01
NO820618L (no) 1982-08-30
ES509956A0 (es) 1983-08-16
DK84982A (da) 1982-08-28
GB2095238B (en) 1984-09-12
IL65108A0 (en) 1982-04-30
PT74498B (de) 1984-11-26
GR78230B (es) 1984-09-26
FI820618L (fi) 1982-08-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009