KR830007840A - β-락탐 화합물의 제조방법 - Google Patents
β-락탐 화합물의 제조방법 Download PDFInfo
- Publication number
- KR830007840A KR830007840A KR1019810003723A KR810003723A KR830007840A KR 830007840 A KR830007840 A KR 830007840A KR 1019810003723 A KR1019810003723 A KR 1019810003723A KR 810003723 A KR810003723 A KR 810003723A KR 830007840 A KR830007840 A KR 830007840A
- Authority
- KR
- South Korea
- Prior art keywords
- preparing
- lactam compound
- culture
- carried out
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 5
- -1 β-lactam compound Chemical class 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 241000187180 Streptomyces sp. Species 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 다음 구조식의 화합물(Ⅰ-a)을 생산할 수 있는 미생물을 영양 배지에서 배양하고, 배양액에서 구조식(Ⅰ-a)화합물을 회수한 후, 필요하면 구조식(Ⅰ-a)화합물을 그 염 또는 치환 또는 비치환의 벤질 에스테르로 전환시키는 공정을 포함하는 제1항의 화합물을 제조하는 방법.(상기식에서, R1은 수소원자, -OH 또는 -OSO3H기이다).
- 제1항의 방법에서, 미생물이 스트렙토마이세스 sp. OA-6129(FERM BP-11)인 방법.
- 제1항의 방법에서, 배양을 호기성 조건하에 행하는 방법.
- 제1항의 방법에서, 배양을 20∼40℃의 온도 및 pH 4∼9에서 행하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP135829/80 | 1980-10-01 | ||
| JP55135829A JPS5762280A (en) | 1980-10-01 | 1980-10-01 | Novel antibiotic oa-6129a and its preparation |
| JP144507/80 | 1980-10-17 | ||
| JP55144507A JPS5770890A (en) | 1980-10-17 | 1980-10-17 | Novel antibiotic oa-6129b and its preparation |
| JP170864/80 | 1980-12-05 | ||
| JP55170864A JPS5795987A (en) | 1980-12-05 | 1980-12-05 | Novel antibiotic oa-6129c and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830007840A true KR830007840A (ko) | 1983-11-07 |
| KR850000577B1 KR850000577B1 (ko) | 1985-04-29 |
Family
ID=27317159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810003723A KR850000577B1 (ko) | 1980-10-01 | 1981-10-02 | β-락탐 화합물의 제조방법 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4426390A (ko) |
| EP (1) | EP0048999B1 (ko) |
| KR (1) | KR850000577B1 (ko) |
| CA (1) | CA1182413A (ko) |
| DE (1) | DE3171598D1 (ko) |
| ES (1) | ES505886A0 (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068485B1 (en) * | 1981-07-01 | 1987-11-11 | Sanraku Incorporated | Novel antibiotics and process for production thereof |
| JPS5857392A (ja) * | 1981-10-02 | 1983-04-05 | Sanraku Inc | 新規な抗生物質ｏａ−６１２９のリン酸エステル |
| KR840003255A (ko) * | 1982-01-28 | 1984-08-20 | 스즈끼 시즈오 | 항생물질 oa-6129a,b1,b2의 유도체 및 그 제법 |
| US5882900A (en) * | 1992-09-10 | 1999-03-16 | Gruppo Lepetit S.P.A. | Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950357A (en) | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
| CH632508A5 (de) * | 1975-11-21 | 1982-10-15 | Merck & Co Inc | Verfahren zur herstellung von neuen estern des n-acylierten thienamycins. |
| AU6377980A (en) * | 1979-10-29 | 1981-05-07 | Beecham Group Limited | 1-azabicyclo(3,2,0)hept-2-ene derivatives |
-
1981
- 1981-09-29 US US06/306,931 patent/US4426390A/en not_active Expired - Fee Related
- 1981-09-30 CA CA000386958A patent/CA1182413A/en not_active Expired
- 1981-09-30 ES ES505886A patent/ES505886A0/es active Granted
- 1981-10-01 DE DE8181107819T patent/DE3171598D1/de not_active Expired
- 1981-10-01 EP EP81107819A patent/EP0048999B1/en not_active Expired
- 1981-10-02 KR KR1019810003723A patent/KR850000577B1/ko active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0048999B1 (en) | 1985-07-31 |
| KR850000577B1 (ko) | 1985-04-29 |
| ES8302093A1 (es) | 1983-01-01 |
| CA1182413A (en) | 1985-02-12 |
| US4426390A (en) | 1984-01-17 |
| ES505886A0 (es) | 1983-01-01 |
| EP0048999A1 (en) | 1982-04-07 |
| DE3171598D1 (en) | 1985-09-05 |
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