KR860001120A - 폴리사이클릭 에테르 항생물질의 제조방법 - Google Patents

폴리사이클릭 에테르 항생물질의 제조방법 Download PDF

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KR860001120A
KR860001120A KR1019850004923A KR850004923A KR860001120A KR 860001120 A KR860001120 A KR 860001120A KR 1019850004923 A KR1019850004923 A KR 1019850004923A KR 850004923 A KR850004923 A KR 850004923A KR 860001120 A KR860001120 A KR 860001120A
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antibiotic
hydrogen
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recovered
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KR1019850004923A
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KR900006233B1 (ko
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코니쉬 루독 존 (외 3)
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원본미기재
화이자 리미티드
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/825—Actinomadura

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  • Tropical Medicine & Parasitology (AREA)
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  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

내용 없음

Description

폴리사이클릭 에테르 항생물질의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 액침 호기성 발효 조건하에 탄소, 질소 및 무기염의 동화원을 함유하는 수성 배양 배지중에서, 일반식(Ⅰ)의 항생물질을 생성할 수 있는 능력을 가진 미생물 액티노마두라 로제오루파 황 종(Actinomadura roseorufa Huang p) ATCC39697 또는 그의 변이주 또는 제조합체를 회수할 수 있는 양의 상기 항생물질이 수득될 때까지 배양시킴을 특징으로 하여 일반식(Ⅰ)의 항생물질 및 약제학적으로 허용되는 그의 양이온염을 제조하는 방법.
    상기 식에서, R 및 R1은 모두 수소이거나;R 은 수소이고 R1은 메틸이거나; 또는 R 및 R1은 모두 메틸이다.
  2. 제1항에 있어서, 항생물질이 발효 배지로부터 분리되는 방법.
  3. 제1항에 있어서, 항생물질이 균사 제제로서 또는 전제 발효 배지의 분무-건조에 의해서 회수되는 방법.
  4. 제2항에 있어서, 항생물질이 그의 나트륨 또는 칼륨염으로 전환되는 방법.
  5. 제1 내지 5항중의 어느 하나에 있어서, R 및 R1이 모두 수소인 방법.
  6. 제1 내지 5항중의 어느 하나에 있어서 , 항생물질이 동물영양 사료와 혼합되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850004923A 1984-07-12 1985-07-11 폴리사이클릭 에테르 항생물질의 제조방법 KR900006233B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848417785A GB8417785D0 (en) 1984-07-12 1984-07-12 Polycyclic ether antibiotic
GB8417785 1984-07-12

Publications (2)

Publication Number Publication Date
KR860001120A true KR860001120A (ko) 1986-02-22
KR900006233B1 KR900006233B1 (ko) 1990-08-27

Family

ID=10563788

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850004923A KR900006233B1 (ko) 1984-07-12 1985-07-11 폴리사이클릭 에테르 항생물질의 제조방법

Country Status (19)

Country Link
US (3) US4746650A (ko)
EP (1) EP0169011B1 (ko)
JP (1) JPS61106591A (ko)
KR (1) KR900006233B1 (ko)
AT (1) ATE36860T1 (ko)
AU (1) AU554477B2 (ko)
CA (1) CA1236414A (ko)
DE (1) DE3564689D1 (ko)
DK (1) DK159451C (ko)
ES (1) ES8607395A1 (ko)
FI (1) FI78732C (ko)
GB (1) GB8417785D0 (ko)
GR (1) GR851720B (ko)
HU (1) HU194312B (ko)
IE (1) IE57818B1 (ko)
IL (1) IL75773A (ko)
PH (1) PH24263A (ko)
PT (1) PT80793B (ko)
ZA (1) ZA855228B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618844D0 (en) * 1986-08-01 1986-09-10 Pfizer Ltd Polycyclic ether antibiotics
US4871866A (en) * 1987-08-24 1989-10-03 Pitman-Moore, Inc. Lysocellin solids purification process
EP0314330B1 (en) * 1987-10-26 1993-10-06 Pfizer Inc. Microbiological process for making uk-61.689 and microorganisms useful therefor
WO1993012800A1 (en) * 1987-11-20 1993-07-08 Dirlam John P An acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant
HU203789B (en) * 1988-02-08 1991-09-30 Pfizer Process for producing polycyclic acidic ether-type antibiotica of anticoccidial and growth-stimulating activity
US5098834A (en) * 1988-05-02 1992-03-24 Eli Lilly And Company Process for producing antibiotic A8210 which comprises cultivating Actinomadura Fibrosa sp nov. NRRL 18348, or an A82810-producing mutant thereof
US5314875A (en) * 1988-05-02 1994-05-24 Eli Lilly And Company Method for treating swine dysentery with the derivatives of the antibiotic A82810
WO1989012105A1 (en) * 1988-06-09 1989-12-14 Pfizer Inc. Acidic polycyclic ether antibiotic having anticoccidial and growth promotant activity
US5298524A (en) * 1988-06-09 1994-03-29 Pfizer Inc. Acidic polycyclic ether antibiotic having an anticoccidial and growth promotant activity
HUT59932A (en) * 1989-06-01 1992-07-28 Pfizer Microbiological process for producing acidic, polycyclic ether-type antibiotica
US5891727A (en) * 1990-04-16 1999-04-06 Pfizer Inc. Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant
US5552387A (en) * 1991-12-09 1996-09-03 Pfizer Inc. Polycyclic ether antibiotics
US5331003A (en) * 1993-03-26 1994-07-19 Eli Lilly And Company Anticoccidial methods
EP2051368A1 (de) * 2007-10-16 2009-04-22 ABB Schweiz AG Verfahren zum Bestimmen der Rotorposition einer fremderregten elektrischen Maschine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5321170A (en) * 1976-08-11 1978-02-27 Microbial Chem Res Found Preparation of branched 2-deoxy-alpha-glycosides
US4153988A (en) * 1977-07-15 1979-05-15 International Business Machines Corporation High performance integrated circuit semiconductor package and method of making
US4278663A (en) * 1980-01-30 1981-07-14 Hoffmann-La Roche Inc. Antibiotic X-14868A, B, C and D
US4565862A (en) * 1982-11-29 1986-01-21 Hoffmann-La Roche Inc. Ethers of antibiotic X-14868A

Also Published As

Publication number Publication date
EP0169011A2 (en) 1986-01-22
GR851720B (ko) 1985-11-26
PT80793B (pt) 1987-10-20
AU4478785A (en) 1986-01-16
US5100785A (en) 1992-03-31
CA1236414A (en) 1988-05-10
DK317085D0 (da) 1985-07-11
FI852692A0 (fi) 1985-07-08
US4746650A (en) 1988-05-24
ZA855228B (en) 1987-02-25
FI78732B (fi) 1989-05-31
DK317085A (da) 1986-01-13
JPS61106591A (ja) 1986-05-24
GB8417785D0 (en) 1984-08-15
DE3564689D1 (en) 1988-10-06
HUT39778A (en) 1986-10-29
AU554477B2 (en) 1986-08-21
IL75773A0 (en) 1985-11-29
JPH0150715B2 (ko) 1989-10-31
DK159451C (da) 1991-03-18
FI78732C (fi) 1989-09-11
KR900006233B1 (ko) 1990-08-27
IE57818B1 (en) 1993-04-21
US4992423A (en) 1991-02-12
EP0169011A3 (en) 1986-06-11
PH24263A (en) 1990-05-29
ES8607395A1 (es) 1986-06-16
DK159451B (da) 1990-10-15
ATE36860T1 (de) 1988-09-15
EP0169011B1 (en) 1988-08-31
IL75773A (en) 1988-05-31
HU194312B (en) 1988-01-28
FI852692L (fi) 1986-01-13
PT80793A (en) 1985-08-01
ES545048A0 (es) 1986-06-16

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