KR850006873A - 산성 폴리사이클릭 에테르 항생물질의 제조방법 - Google Patents

산성 폴리사이클릭 에테르 항생물질의 제조방법 Download PDF

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KR850006873A
KR850006873A KR1019850000931A KR850000931A KR850006873A KR 850006873 A KR850006873 A KR 850006873A KR 1019850000931 A KR1019850000931 A KR 1019850000931A KR 850000931 A KR850000931 A KR 850000931A KR 850006873 A KR850006873 A KR 850006873A
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antibiotic
streptomyces
aureus
atcc
pharmaceutically acceptable
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KR1019850000931A
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KR870000236B1 (ko
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다니엘 켈머 왈터 (외 3)
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윌리암 데이비스 훈
화이자 인코포레이티드
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Publication of KR850006873A publication Critical patent/KR850006873A/ko
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Fodder In General (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음

Description

산성 폴리사이클릭 에테르 항생물질의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 항생물질 생성능을 갖는 스트렙토마이세스 엔두스 아종 아우레우스(streptomyces endussubspaureus)ATCC-39754를 탄소동화원, 질소 및 무기염을 함유하는 수성배지중, 액침 호기성 발효조건하에서 상당량의 구조식(Ⅰ)의 항생물질 또는 그의 약제학적으로 허용되는 양이온성 염이 수득될 때까지 배양함을 특징으로 하여, 다음 구조식(Ⅰ)의 항생물질 또는 그의 약제학적으로 허용되는 양이온성염을 제조하는 방법.
    (Ⅰ)
    상기식에서 Me는 메틸이다.
  2. 제1항에 있어서, 스트렙토마이세스 엔두스 아종 아우레우스가 균주 ATCC-39574 또는 그의 돌연변이체인 방법.
  3. 제1항에 있어서, 항생물질이 그의 나트륨염 또는 칼륨염의 형태로 수득되는 방법.
  4. 제1항에 있어서, 배양을 24 내지 36℃의 온도에서 수행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850000931A 1984-02-17 1985-02-15 산성 폴리사이클릭 에테르 항생물질의 제조방법 KR870000236B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US581384 1984-02-17
US581,384 1984-02-17
US06/581,384 US4552843A (en) 1984-02-17 1984-02-17 Process for producing an acidic polycyclic ether antibiotic by cultivation of a novel strain of Streptomyces endus subspecies aureus

Publications (2)

Publication Number Publication Date
KR850006873A true KR850006873A (ko) 1985-10-21
KR870000236B1 KR870000236B1 (ko) 1987-02-18

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ID=24324993

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KR1019850000931A KR870000236B1 (ko) 1984-02-17 1985-02-15 산성 폴리사이클릭 에테르 항생물질의 제조방법

Country Status (25)

Country Link
US (1) US4552843A (ko)
EP (1) EP0153128B1 (ko)
JP (1) JPS60199895A (ko)
KR (1) KR870000236B1 (ko)
AT (1) ATE41424T1 (ko)
AU (1) AU552957B2 (ko)
CA (1) CA1234771A (ko)
DE (1) DE3568781D1 (ko)
DK (1) DK158988C (ko)
ES (1) ES8605861A1 (ko)
FI (1) FI78118C (ko)
GR (1) GR850399B (ko)
HU (1) HU194311B (ko)
IE (1) IE58131B1 (ko)
IL (1) IL74353A (ko)
MX (1) MX164678B (ko)
NO (1) NO164422C (ko)
NZ (1) NZ211133A (ko)
PH (1) PH19992A (ko)
PL (1) PL145197B1 (ko)
PT (1) PT79974B (ko)
SU (1) SU1431682A3 (ko)
YU (1) YU43398B (ko)
ZA (1) ZA851160B (ko)
ZW (1) ZW2085A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510317A (en) * 1983-07-28 1985-04-09 Hoffmann-La Roche Inc. Antibiotic X-14934A
US5242814A (en) * 1989-10-10 1993-09-07 Eli Lilly And Company Polyether antibiotic
US5573724A (en) * 1994-07-29 1996-11-12 Magneco/Metrel, Inc. Ladle port assembly

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5592387A (en) * 1978-12-29 1980-07-12 Taisho Pharmaceut Co Ltd Antibiotic substance tm-531
JPS574975A (en) * 1980-06-12 1982-01-11 Kyowa Hakko Kogyo Co Ltd Phenazine derivative and its preparation
US4359583A (en) * 1980-09-16 1982-11-16 Taisho Pharmaceutical Co., Ltd. Antibiotics TM-531 B and TM-531 C
JPS5758687A (en) * 1980-09-27 1982-04-08 Taisho Pharmaceut Co Ltd Antibiotic
US4361649A (en) * 1981-07-20 1982-11-30 Pfizer Inc. Polycyclic ether antibiotic

Also Published As

Publication number Publication date
EP0153128A2 (en) 1985-08-28
ATE41424T1 (de) 1989-04-15
ZW2085A1 (en) 1985-05-22
GR850399B (ko) 1985-06-14
ZA851160B (en) 1986-10-29
IE58131B1 (en) 1993-07-14
HUT37655A (en) 1986-01-23
JPS643875B2 (ko) 1989-01-23
FI850650A0 (fi) 1985-02-15
PL251964A1 (en) 1985-11-19
IE850381L (en) 1985-08-17
HU194311B (en) 1988-01-28
NO164422C (no) 1990-10-03
NO164422B (no) 1990-06-25
NZ211133A (en) 1988-04-29
ES8605861A1 (es) 1986-04-01
IL74353A (en) 1987-12-20
DK158988B (da) 1990-08-13
IL74353A0 (en) 1985-05-31
JPS60199895A (ja) 1985-10-09
FI78118C (fi) 1989-06-12
DK71285D0 (da) 1985-02-15
SU1431682A3 (ru) 1988-10-15
PL145197B1 (en) 1988-08-31
PT79974B (en) 1987-02-02
PT79974A (en) 1985-03-01
US4552843A (en) 1985-11-12
YU43398B (en) 1989-06-30
AU3875985A (en) 1985-08-22
YU6485A (en) 1987-12-31
FI78118B (fi) 1989-02-28
DK71285A (da) 1985-08-18
FI850650L (fi) 1985-08-18
CA1234771A (en) 1988-04-05
ES540399A0 (es) 1986-04-01
DE3568781D1 (en) 1989-04-20
EP0153128A3 (en) 1987-01-21
KR870000236B1 (ko) 1987-02-18
DK158988C (da) 1991-01-07
AU552957B2 (en) 1986-06-26
PH19992A (en) 1986-08-28
EP0153128B1 (en) 1989-03-15
NO850609L (no) 1985-08-19
MX164678B (es) 1992-09-14

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