KR840004442A - 란카시딘의 개량 제조방법 - Google Patents

란카시딘의 개량 제조방법 Download PDF

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Publication number
KR840004442A
KR840004442A KR1019830001508A KR830001508A KR840004442A KR 840004442 A KR840004442 A KR 840004442A KR 1019830001508 A KR1019830001508 A KR 1019830001508A KR 830001508 A KR830001508 A KR 830001508A KR 840004442 A KR840004442 A KR 840004442A
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South Korea
Prior art keywords
microorganism
streptomyces
cyclodextrin
culture medium
lancassidine
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KR1019830001508A
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English (en)
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KR920009510B1 (ko
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다까시 스즈끼 (외 2)
Original Assignee
구라바야시 이꾸시로
다께다 야꾸힝 고오교 가부시끼 가이샤
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Publication of KR840004442A publication Critical patent/KR840004442A/ko
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Publication of KR920009510B1 publication Critical patent/KR920009510B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음

Description

란카시딘의 개량 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 시클로덱스트린을 배양 배지에 가하여 란카시딘을 제조할 수 있는 미생물을 배양함을 특징으로 하는 란카시딘 항생물질의 개량 제조방법.
  2. 제1항에 있어서, 상기 시클로덱스트린을 미생물이 배양 배지에 접종 또는 이식되기 전에 배양 배지에 가하며, 배지에서의 시클로덱스트린의 농도가 1~150mM임을 특징으로 하는 방법.
  3. 제1항에 있어서, 상기 미생물이스트렙토미세스 var.볼루비리리스(ATCC-21250),스트렙토미세스 그리세오푸스쿠스(ATCC-23910),스트렙토미세스 비올라세오니거(IFC-14166) 또는스트렙토미세스sp.6642-GC1,(IFC-14172)임을 특징으로 하는 방법.
  4. 시클로덱스트린을 함유한 배양 배지에서 란카시딘을 제조할 수 있는 미생물을 배양하고, 생성된 배양 브로스 또는 그의 여과액에 저급 알킬 카르복실레이트를 가하여 에스테르화 반응을 시킴을 특징으로하는 란카시딘 14-아실 유도체 또는 이를 주성분으로 함유한 혼합물의 제조방법.
  5. 제4항에 있어서, 저급 알킬 카르복실레이트가 에틸 아세레이트이며 란카시딘 14-아실 유도체 또는 이를 주성분으로 함유한 혼합물은 란카시딘 C의 14-아세틸 유도체 또는 이를 주성분으로 함유한 혼합물임을 특징으로 하는 방법.
  6. 제5항에 있어서,스트렙토미세스 var. 볼루빌리스(ATCC-21250)가 배양될 미생물임을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001508A 1982-04-12 1983-04-11 란카시딘의 개량 제조방법 KR920009510B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP61342 1982-04-12
JP61342/82 1982-04-12
JP57061342A JPS58179496A (ja) 1982-04-12 1982-04-12 ランカシジンの改良製造法

Publications (2)

Publication Number Publication Date
KR840004442A true KR840004442A (ko) 1984-10-15
KR920009510B1 KR920009510B1 (ko) 1992-10-17

Family

ID=13168356

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001508A KR920009510B1 (ko) 1982-04-12 1983-04-11 란카시딘의 개량 제조방법

Country Status (11)

Country Link
US (1) US4480033A (ko)
EP (1) EP0091781B1 (ko)
JP (1) JPS58179496A (ko)
KR (1) KR920009510B1 (ko)
CA (1) CA1190165A (ko)
DE (1) DE3367618D1 (ko)
DK (1) DK160510C (ko)
ES (1) ES521361A0 (ko)
HU (1) HU192960B (ko)
SG (1) SG86088G (ko)
ZA (1) ZA832470B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61271986A (ja) * 1985-05-27 1986-12-02 Agency Of Ind Science & Technol リンパ系細胞用培地
US4914206A (en) * 1985-10-06 1990-04-03 Takeda Chemical Industries, Ltd. Lankacidin derivatives and production thereof
ES2058057T3 (es) * 1985-12-05 1994-11-01 Takeda Chemical Industries Ltd Derivados de lancacidina y su produccion.
EP0269453B1 (en) * 1986-11-28 1993-03-17 Takeda Chemical Industries, Ltd. A process for producing carboxylic acid esters
US5436140A (en) * 1988-02-02 1995-07-25 Fujisawa Pharmaceutical Co., Ltd. Process for producing WS-9326A and WS-9326B
US5217952A (en) * 1988-02-02 1993-06-08 Fujisawa Pharmaceutical Co., Ltd. Peptides WS-9326a and WS-9326b, derivatives thereof and uses thereof
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
JPWO2005073223A1 (ja) * 2004-01-29 2007-09-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 マクロライド系化合物の安定化方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3188272A (en) * 1954-11-29 1965-06-08 Univ Illinois Antibiotic filipin
DK117626C (da) * 1967-05-18 1970-10-19 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af det antibiotiske stof T-2636 eller dets komponenter.
JPS4810442B1 (ko) * 1968-10-26 1973-04-03

Also Published As

Publication number Publication date
DK158983A (da) 1983-10-13
KR920009510B1 (ko) 1992-10-17
EP0091781A1 (en) 1983-10-19
EP0091781B1 (en) 1986-11-12
ES8502159A1 (es) 1984-12-16
DK158983D0 (da) 1983-04-11
DK160510B (da) 1991-03-18
ZA832470B (en) 1983-12-28
JPS6314950B2 (ko) 1988-04-02
DK160510C (da) 1991-08-26
CA1190165A (en) 1985-07-09
SG86088G (en) 1989-06-16
JPS58179496A (ja) 1983-10-20
DE3367618D1 (en) 1987-01-02
HU192960B (en) 1987-08-28
ES521361A0 (es) 1984-12-16
US4480033A (en) 1984-10-30

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