ES463206A1 - Un metodo para preparar maytansinol, maytanacina o propiona-to de maytansinol. - Google Patents
Un metodo para preparar maytansinol, maytanacina o propiona-to de maytansinol.Info
- Publication number
- ES463206A1 ES463206A1 ES463206A ES463206A ES463206A1 ES 463206 A1 ES463206 A1 ES 463206A1 ES 463206 A ES463206 A ES 463206A ES 463206 A ES463206 A ES 463206A ES 463206 A1 ES463206 A1 ES 463206A1
- Authority
- ES
- Spain
- Prior art keywords
- maytansinol
- maytanacin
- derivatives
- propionate
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 title abstract 4
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- MQYZCKOGTWYJAZ-UHFFFAOYSA-N ansamitocin P1 Natural products CN1C(=O)CC(OC(C)=O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 MQYZCKOGTWYJAZ-UHFFFAOYSA-N 0.000 abstract 3
- DGBBXVWXOHSLTG-UMDRASRXSA-N ansamitocin p 2 Chemical compound C([C@@H]([C@@]1(O[C@H]1[C@@H]1C)C)OC(=O)CC)C(=O)N(C)C(C(=C(OC)C=2)Cl)=CC=2C\C(C)=C\C=C\[C@@H](OC)[C@]2(O)NC(=O)O[C@H]1C2 DGBBXVWXOHSLTG-UMDRASRXSA-N 0.000 abstract 3
- 241000187654 Nocardia Species 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Dispositivo de inmovilización y de conmutación eléctrica, destinado a ser fijado a un soporte de circuito eléctrico, tal como un panel de circuito impreso y unido a este circuito eléctrico, caracterizado porque la maniobra de rotación de una manilla del dispositivo permite instantánea y simultáneamente, bien bloquear mecánicamente el soporte en una posición fija, así como conmutar su circuito bajo tensión, bien, inversamente, desbloquearlo y ponerlo fuera de tensión, porque comprende un estribo en U que contiene un bloque aislante, una primera palanca con dedo de bloqueo que puede pivotar libremente alrededor de un eje de un conmutador rotativo que lleva solidariamente una segunda palanca provista de dicha manilla que se extiende en dirección opuesta al dedo de bloqueo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52037167A JPS6010718B2 (ja) | 1977-03-31 | 1977-03-31 | メイタンシノ−ル,メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES463206A1 true ES463206A1 (es) | 1978-08-16 |
Family
ID=12490032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES463206A Expired ES463206A1 (es) | 1977-03-31 | 1977-10-14 | Un metodo para preparar maytansinol, maytanacina o propiona-to de maytansinol. |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS6010718B2 (es) |
AT (1) | AT362058B (es) |
AU (1) | AU507869B2 (es) |
CA (1) | CA1092999A (es) |
CH (1) | CH631740A5 (es) |
CS (1) | CS214881B2 (es) |
DE (1) | DE2746253C2 (es) |
DK (1) | DK143570C (es) |
ES (1) | ES463206A1 (es) |
FR (1) | FR2385798A1 (es) |
GB (1) | GB1554395A (es) |
HU (1) | HU177391B (es) |
IE (1) | IE45888B1 (es) |
IT (1) | IT1094003B (es) |
NL (1) | NL7711273A (es) |
PL (1) | PL108863B1 (es) |
PT (1) | PT67853B (es) |
SE (1) | SE7711543L (es) |
SU (1) | SU938746A3 (es) |
YU (1) | YU243777A (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6016236B2 (ja) * | 1977-11-18 | 1985-04-24 | 武田薬品工業株式会社 | 抗生物質c―15003 p―3の製造法 |
JPS6010720B2 (ja) * | 1977-11-18 | 1985-03-19 | 武田薬品工業株式会社 | 抗生物質c―15003 p―4の製造法 |
JPS55162791A (en) * | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
EP0028683A1 (en) * | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
US6573074B2 (en) * | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
US7432088B2 (en) | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
CN116239607B (zh) * | 2023-01-04 | 2024-04-09 | 山东大学 | 一种美登素衍生物及其生物合成方法与应用 |
-
1977
- 1977-03-31 JP JP52037167A patent/JPS6010718B2/ja not_active Expired
- 1977-09-23 AU AU29073/77A patent/AU507869B2/en not_active Expired
- 1977-10-07 FR FR7730340A patent/FR2385798A1/fr active Granted
- 1977-10-07 SU SU772533351A patent/SU938746A3/ru active
- 1977-10-10 YU YU02437/77A patent/YU243777A/xx unknown
- 1977-10-13 HU HU77TA1458A patent/HU177391B/hu unknown
- 1977-10-13 SE SE7711543A patent/SE7711543L/ not_active Application Discontinuation
- 1977-10-13 CS CS776677A patent/CS214881B2/cs unknown
- 1977-10-13 NL NL7711273A patent/NL7711273A/xx not_active Application Discontinuation
- 1977-10-14 ES ES463206A patent/ES463206A1/es not_active Expired
- 1977-10-14 AT AT736377A patent/AT362058B/de not_active IP Right Cessation
- 1977-10-14 DE DE2746253A patent/DE2746253C2/de not_active Expired
- 1977-10-14 DK DK458977A patent/DK143570C/da not_active IP Right Cessation
- 1977-10-14 CA CA288,732A patent/CA1092999A/en not_active Expired
- 1977-10-14 CH CH1260477A patent/CH631740A5/de not_active IP Right Cessation
- 1977-10-14 IE IE2100/77A patent/IE45888B1/en unknown
- 1977-10-14 GB GB42821/77A patent/GB1554395A/en not_active Expired
- 1977-10-15 PL PL1977201539A patent/PL108863B1/pl not_active IP Right Cessation
-
1978
- 1978-03-30 IT IT21819/78A patent/IT1094003B/it active
- 1978-03-30 PT PT67853A patent/PT67853B/pt unknown
Also Published As
Publication number | Publication date |
---|---|
DK143570B (da) | 1981-09-07 |
NL7711273A (nl) | 1978-10-03 |
DK143570C (da) | 1982-02-08 |
DK458977A (da) | 1978-10-01 |
SE7711543L (sv) | 1978-10-01 |
AT362058B (de) | 1981-04-27 |
AU2907377A (en) | 1979-03-29 |
CA1092999A (en) | 1981-01-06 |
IE45888L (en) | 1978-09-30 |
DE2746253A1 (de) | 1978-10-05 |
CS214881B2 (en) | 1982-06-25 |
DE2746253C2 (de) | 1986-08-21 |
IE45888B1 (en) | 1982-12-29 |
JPS53121998A (en) | 1978-10-24 |
FR2385798B1 (es) | 1980-04-25 |
PT67853B (en) | 1980-05-05 |
PL201539A1 (pl) | 1978-09-25 |
YU243777A (en) | 1982-06-30 |
IT7821819A0 (it) | 1978-03-30 |
SU938746A3 (ru) | 1982-06-23 |
CH631740A5 (en) | 1982-08-31 |
HU177391B (en) | 1981-09-28 |
PT67853A (en) | 1978-04-01 |
PL108863B1 (en) | 1980-05-31 |
FR2385798A1 (fr) | 1978-10-27 |
ATA736377A (de) | 1980-09-15 |
IT1094003B (it) | 1985-07-26 |
JPS6010718B2 (ja) | 1985-03-19 |
AU507869B2 (en) | 1980-02-28 |
GB1554395A (en) | 1979-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19981103 |