ES465940A1 - Procedimiento para la preparacion de un inhibidor peptidico de hidrolasa de glicosidos. - Google Patents

Procedimiento para la preparacion de un inhibidor peptidico de hidrolasa de glicosidos.

Info

Publication number
ES465940A1
ES465940A1 ES465940A ES465940A ES465940A1 ES 465940 A1 ES465940 A1 ES 465940A1 ES 465940 A ES465940 A ES 465940A ES 465940 A ES465940 A ES 465940A ES 465940 A1 ES465940 A1 ES 465940A1
Authority
ES
Spain
Prior art keywords
alpha
streptomycete
preparation
amylase inhibitor
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465940A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES465940A1 publication Critical patent/ES465940A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/823—Lower fungi, e.g. mold
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Abstract

Procedimiento para la preparación de un inhibidor peptídico de hidrolasa de glicósidos con un peso molecular de 5.000 a 10.000 con un máximo de absorción en luz ultravioleta a 276 nmcon un punto isoeléctrico de 4,4 y con la siguiente composición de aminoácidos: Acido aspártico5 - 6Isoleucina 1 - 2 Treonina5 - 6Leucina 3 - 4 Serina 3 - 5 Tirosina 4 - 5 Acido glutámico5 - 6 Fenilalanina 0- 2 Prolina 2 - 3 Histidina 1 - 2 Glicina5 - 6 Lisina 0 - 1 Alanina 5 - 6 Arginina 2 - 3 Cisteína3 - 4 Triptófano 1 - 2 Valina 5 - 6 caracterizado porque se cultiva Streptomyces tendea 4158 (ATCC Nº 31210) y se obtiene el inhibidor a partir del cultivo.
ES465940A 1977-01-19 1978-01-13 Procedimiento para la preparacion de un inhibidor peptidico de hidrolasa de glicosidos. Expired ES465940A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2701890A DE2701890C2 (de) 1977-01-19 1977-01-19 Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung

Publications (1)

Publication Number Publication Date
ES465940A1 true ES465940A1 (es) 1978-09-16

Family

ID=5998949

Family Applications (1)

Application Number Title Priority Date Filing Date
ES465940A Expired ES465940A1 (es) 1977-01-19 1978-01-13 Procedimiento para la preparacion de un inhibidor peptidico de hidrolasa de glicosidos.

Country Status (10)

Country Link
US (3) US4226764A (es)
JP (1) JPS5390201A (es)
AT (1) AT363891B (es)
BE (1) BE863089A (es)
CA (1) CA1105404A (es)
DE (1) DE2701890C2 (es)
ES (1) ES465940A1 (es)
FR (1) FR2378041A1 (es)
GB (1) GB1599372A (es)
NL (1) NL7800630A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2900591A1 (de) * 1979-01-09 1980-07-17 Bayer Ag Antibiotica, ein verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel
DE2928137A1 (de) 1979-07-12 1981-02-05 Bayer Ag Neue nikkomycine, ein verfahren zu ihrer herstellung sowie ihre verwendung als schaedlingsbekaempfungsmittel
JPS5910193B2 (ja) * 1980-06-04 1984-03-07 富士レビオ株式会社 アミラ−ゼ阻害物質ａｉ−ｂの製造法
ES505959A0 (es) * 1980-10-09 1982-09-01 Hoechst Ag Procedimiento para la preparacion de un inactivador de alfa-amilasa
JPS5885899A (ja) * 1981-11-16 1983-05-23 Fujirebio Inc アミラ−ゼインヒビタ−およびその製造法
FI844289L (fi) * 1984-01-21 1985-07-22 Hoechst Ag Nya polypeptider med -amylashaemmande verkan, foerfarande foer deras framstaellning, deras anvaendning och farmaceutiska preparat.
DE3536182A1 (de) * 1985-10-10 1987-04-16 Hoechst Ag Promotor-anordnung fuer streptomyceten-vektoren
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
RU2495930C1 (ru) * 2012-06-27 2013-10-20 Государственное научное учреждение Всероссийский научно-исследовательский институт пищевых ароматизаторов, кислот и красителей Российской академии сельскохозяйственных наук (ГНУ ВНИИПАКК Россельхозакадемии) Способ получения ингибитора гликозидаз

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34869B1 (en) 1970-01-29 1975-09-03 Bayer Ag Amylase inhibitor,processes for its production,and compositions containing it
DE2064092C2 (de) * 1970-12-28 1983-06-01 Bayer Ag, 5090 Leverkusen Inhibitoren für Glykosidhydrolasen aus Actinomyceten
JPS5111197B1 (es) * 1971-05-31 1976-04-09
DE2209834C3 (de) * 1972-03-01 1978-04-20 Bayer Ag, 5090 Leverkusen Herstellung von Saccharase-Inhibitoren
DE2209833C3 (de) * 1972-03-01 1978-06-01 Bayer Ag, 5090 Leverkusen Herstellung eines Amylaseinhibitors
US4010258A (en) 1974-03-15 1977-03-01 Ajinomoto Co., Inc. Microbial amylase inhibitor and preparation thereof with the use of streptomyces diasticus var. amylostaticus
JPS5259475A (en) * 1975-11-07 1977-05-16 Hitachi Ltd Palletizer for mixed transportation
FR2338707A1 (fr) * 1976-01-22 1977-08-19 Rhone Poulenc Ind Nouvel inhibiteur de glyco-hydrolases et sa preparation par culture d'un streptomyces
DE2716050A1 (de) * 1977-04-09 1978-10-19 Hoechst Ag Alpha-amylase-inhibitor aus einem streptomyceten und verfahren zu seiner gewinnung

Also Published As

Publication number Publication date
DE2701890A1 (de) 1978-07-27
FR2378041B1 (es) 1980-07-04
ATA35578A (de) 1981-02-15
DE2701890C2 (de) 1983-08-04
CA1105404A (en) 1981-07-21
NL7800630A (nl) 1978-07-21
US4226764A (en) 1980-10-07
JPS6236040B2 (es) 1987-08-05
JPS5390201A (en) 1978-08-08
US4339436A (en) 1982-07-13
US4282318A (en) 1981-08-04
BE863089A (fr) 1978-07-19
FR2378041A1 (fr) 1978-08-18
AT363891B (de) 1981-09-10
GB1599372A (en) 1981-09-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000103