ES465940A1 - Procedimiento para la preparacion de un inhibidor peptidico de hidrolasa de glicosidos. - Google Patents
Procedimiento para la preparacion de un inhibidor peptidico de hidrolasa de glicosidos.Info
- Publication number
- ES465940A1 ES465940A1 ES465940A ES465940A ES465940A1 ES 465940 A1 ES465940 A1 ES 465940A1 ES 465940 A ES465940 A ES 465940A ES 465940 A ES465940 A ES 465940A ES 465940 A1 ES465940 A1 ES 465940A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- streptomycete
- preparation
- amylase inhibitor
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/823—Lower fungi, e.g. mold
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procedimiento para la preparación de un inhibidor peptídico de hidrolasa de glicósidos con un peso molecular de 5.000 a 10.000 con un máximo de absorción en luz ultravioleta a 276 nmcon un punto isoeléctrico de 4,4 y con la siguiente composición de aminoácidos: Acido aspártico5 - 6Isoleucina 1 - 2 Treonina5 - 6Leucina 3 - 4 Serina 3 - 5 Tirosina 4 - 5 Acido glutámico5 - 6 Fenilalanina 0- 2 Prolina 2 - 3 Histidina 1 - 2 Glicina5 - 6 Lisina 0 - 1 Alanina 5 - 6 Arginina 2 - 3 Cisteína3 - 4 Triptófano 1 - 2 Valina 5 - 6 caracterizado porque se cultiva Streptomyces tendea 4158 (ATCC Nº 31210) y se obtiene el inhibidor a partir del cultivo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2701890A DE2701890C2 (de) | 1977-01-19 | 1977-01-19 | Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES465940A1 true ES465940A1 (es) | 1978-09-16 |
Family
ID=5998949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES465940A Expired ES465940A1 (es) | 1977-01-19 | 1978-01-13 | Procedimiento para la preparacion de un inhibidor peptidico de hidrolasa de glicosidos. |
Country Status (10)
Country | Link |
---|---|
US (3) | US4226764A (es) |
JP (1) | JPS5390201A (es) |
AT (1) | AT363891B (es) |
BE (1) | BE863089A (es) |
CA (1) | CA1105404A (es) |
DE (1) | DE2701890C2 (es) |
ES (1) | ES465940A1 (es) |
FR (1) | FR2378041A1 (es) |
GB (1) | GB1599372A (es) |
NL (1) | NL7800630A (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2900591A1 (de) * | 1979-01-09 | 1980-07-17 | Bayer Ag | Antibiotica, ein verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel |
DE2928137A1 (de) | 1979-07-12 | 1981-02-05 | Bayer Ag | Neue nikkomycine, ein verfahren zu ihrer herstellung sowie ihre verwendung als schaedlingsbekaempfungsmittel |
JPS5910193B2 (ja) * | 1980-06-04 | 1984-03-07 | 富士レビオ株式会社 | アミラ−ゼ阻害物質ai−bの製造法 |
ES8207217A1 (es) * | 1980-10-09 | 1982-09-01 | Hoechst Ag | Procedimiento para la preparacion de un inactivador de alfa-amilasa |
JPS5885899A (ja) * | 1981-11-16 | 1983-05-23 | Fujirebio Inc | アミラ−ゼインヒビタ−およびその製造法 |
FI844289L (fi) * | 1984-01-21 | 1985-07-22 | Hoechst Ag | Nya polypeptider med -amylashaemmande verkan, foerfarande foer deras framstaellning, deras anvaendning och farmaceutiska preparat. |
DE3536182A1 (de) * | 1985-10-10 | 1987-04-16 | Hoechst Ag | Promotor-anordnung fuer streptomyceten-vektoren |
GB2199582A (en) * | 1987-01-07 | 1988-07-13 | Bayer Ag | Analogues of pancreatic secretory trypsin inhibitor |
RU2495930C1 (ru) * | 2012-06-27 | 2013-10-20 | Государственное научное учреждение Всероссийский научно-исследовательский институт пищевых ароматизаторов, кислот и красителей Российской академии сельскохозяйственных наук (ГНУ ВНИИПАКК Россельхозакадемии) | Способ получения ингибитора гликозидаз |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL35986A (en) | 1970-01-29 | 1974-10-22 | Bayer Ag | Amylase inhibitor,its production and use |
DE2064092C2 (de) * | 1970-12-28 | 1983-06-01 | Bayer Ag, 5090 Leverkusen | Inhibitoren für Glykosidhydrolasen aus Actinomyceten |
JPS5111197B1 (es) * | 1971-05-31 | 1976-04-09 | ||
DE2209833C3 (de) * | 1972-03-01 | 1978-06-01 | Bayer Ag, 5090 Leverkusen | Herstellung eines Amylaseinhibitors |
DE2209834C3 (de) * | 1972-03-01 | 1978-04-20 | Bayer Ag, 5090 Leverkusen | Herstellung von Saccharase-Inhibitoren |
US4010258A (en) | 1974-03-15 | 1977-03-01 | Ajinomoto Co., Inc. | Microbial amylase inhibitor and preparation thereof with the use of streptomyces diasticus var. amylostaticus |
JPS5259475A (en) * | 1975-11-07 | 1977-05-16 | Hitachi Ltd | Palletizer for mixed transportation |
FR2338707A1 (fr) * | 1976-01-22 | 1977-08-19 | Rhone Poulenc Ind | Nouvel inhibiteur de glyco-hydrolases et sa preparation par culture d'un streptomyces |
DE2716050A1 (de) * | 1977-04-09 | 1978-10-19 | Hoechst Ag | Alpha-amylase-inhibitor aus einem streptomyceten und verfahren zu seiner gewinnung |
-
1977
- 1977-01-19 DE DE2701890A patent/DE2701890C2/de not_active Expired
-
1978
- 1978-01-13 ES ES465940A patent/ES465940A1/es not_active Expired
- 1978-01-17 US US05/870,247 patent/US4226764A/en not_active Expired - Lifetime
- 1978-01-18 AT AT0035578A patent/AT363891B/de not_active IP Right Cessation
- 1978-01-18 FR FR7801387A patent/FR2378041A1/fr active Granted
- 1978-01-18 CA CA295,189A patent/CA1105404A/en not_active Expired
- 1978-01-18 NL NL7800630A patent/NL7800630A/xx not_active Application Discontinuation
- 1978-01-19 BE BE184460A patent/BE863089A/xx not_active IP Right Cessation
- 1978-01-19 GB GB2226/78A patent/GB1599372A/en not_active Expired
- 1978-01-19 JP JP479678A patent/JPS5390201A/ja active Granted
-
1980
- 1980-01-02 US US06/109,170 patent/US4282318A/en not_active Expired - Lifetime
-
1981
- 1981-02-23 US US06/237,097 patent/US4339436A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2378041A1 (fr) | 1978-08-18 |
US4226764A (en) | 1980-10-07 |
JPS6236040B2 (es) | 1987-08-05 |
FR2378041B1 (es) | 1980-07-04 |
CA1105404A (en) | 1981-07-21 |
BE863089A (fr) | 1978-07-19 |
US4282318A (en) | 1981-08-04 |
DE2701890C2 (de) | 1983-08-04 |
NL7800630A (nl) | 1978-07-21 |
DE2701890A1 (de) | 1978-07-27 |
JPS5390201A (en) | 1978-08-08 |
ATA35578A (de) | 1981-02-15 |
US4339436A (en) | 1982-07-13 |
AT363891B (de) | 1981-09-10 |
GB1599372A (en) | 1981-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000103 |