FR2378041A1 - Inhibiteur d'a-amylase, son procede de preparation a partir d'un streptomycete et son application en therapeutique - Google Patents

Inhibiteur d'a-amylase, son procede de preparation a partir d'un streptomycete et son application en therapeutique

Info

Publication number
FR2378041A1
FR2378041A1 FR7801387A FR7801387A FR2378041A1 FR 2378041 A1 FR2378041 A1 FR 2378041A1 FR 7801387 A FR7801387 A FR 7801387A FR 7801387 A FR7801387 A FR 7801387A FR 2378041 A1 FR2378041 A1 FR 2378041A1
Authority
FR
France
Prior art keywords
streptomycetis
therapeutics
application
preparation process
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7801387A
Other languages
English (en)
Other versions
FR2378041B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2378041A1 publication Critical patent/FR2378041A1/fr
Application granted granted Critical
Publication of FR2378041B1 publication Critical patent/FR2378041B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/823—Lower fungi, e.g. mold
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Abstract

L'invention a pour objet un inhibiteur peptidique de glycosidehydrolase, caractérisé en ce qu'il a un poids moléculaire de 5 000 à 10 000, un maximum d'absorption en lumière UV à 276 nm, un point isoélectrique de 4,4 et la composition suivante en acides aminés : Acide asparaginique 5-6 Isoleucine 1-2 Thréonine 5-6 Leucine 3-4 Serine 3-5 Tyrosine 4-5 Acide glutaminique 5-6 Phénylalanine 0-2 Proline 2-3 Histidine 1-2 Glycine 5-6 Lysine 0-1 Alanine 5-6 Arginine 2-3 Cystéine 3-4 Tryptophane 1-2 Valine 5-6 Cet inhibiteur est utilisable notamment comme régulateur du taux de sucre dans le sang.
FR7801387A 1977-01-19 1978-01-18 Inhibiteur d'a-amylase, son procede de preparation a partir d'un streptomycete et son application en therapeutique Granted FR2378041A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2701890A DE2701890C2 (de) 1977-01-19 1977-01-19 Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung

Publications (2)

Publication Number Publication Date
FR2378041A1 true FR2378041A1 (fr) 1978-08-18
FR2378041B1 FR2378041B1 (fr) 1980-07-04

Family

ID=5998949

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7801387A Granted FR2378041A1 (fr) 1977-01-19 1978-01-18 Inhibiteur d'a-amylase, son procede de preparation a partir d'un streptomycete et son application en therapeutique

Country Status (10)

Country Link
US (3) US4226764A (fr)
JP (1) JPS5390201A (fr)
AT (1) AT363891B (fr)
BE (1) BE863089A (fr)
CA (1) CA1105404A (fr)
DE (1) DE2701890C2 (fr)
ES (1) ES465940A1 (fr)
FR (1) FR2378041A1 (fr)
GB (1) GB1599372A (fr)
NL (1) NL7800630A (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2900591A1 (de) * 1979-01-09 1980-07-17 Bayer Ag Antibiotica, ein verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel
DE2928137A1 (de) 1979-07-12 1981-02-05 Bayer Ag Neue nikkomycine, ein verfahren zu ihrer herstellung sowie ihre verwendung als schaedlingsbekaempfungsmittel
JPS5910193B2 (ja) * 1980-06-04 1984-03-07 富士レビオ株式会社 アミラ−ゼ阻害物質ａｉ−ｂの製造法
ES505959A0 (es) * 1980-10-09 1982-09-01 Hoechst Ag Procedimiento para la preparacion de un inactivador de alfa-amilasa
JPS5885899A (ja) * 1981-11-16 1983-05-23 Fujirebio Inc アミラ−ゼインヒビタ−およびその製造法
FI844289L (fi) * 1984-01-21 1985-07-22 Hoechst Ag Nya polypeptider med -amylashaemmande verkan, foerfarande foer deras framstaellning, deras anvaendning och farmaceutiska preparat.
DE3536182A1 (de) * 1985-10-10 1987-04-16 Hoechst Ag Promotor-anordnung fuer streptomyceten-vektoren
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
RU2495930C1 (ru) * 2012-06-27 2013-10-20 Государственное научное учреждение Всероссийский научно-исследовательский институт пищевых ароматизаторов, кислот и красителей Российской академии сельскохозяйственных наук (ГНУ ВНИИПАКК Россельхозакадемии) Способ получения ингибитора гликозидаз

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2120073A1 (fr) * 1970-12-28 1972-08-11 Bayer Ag
JPS5259475A (en) * 1975-11-07 1977-05-16 Hitachi Ltd Palletizer for mixed transportation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34869B1 (en) 1970-01-29 1975-09-03 Bayer Ag Amylase inhibitor,processes for its production,and compositions containing it
JPS5111197B1 (fr) * 1971-05-31 1976-04-09
DE2209834C3 (de) * 1972-03-01 1978-04-20 Bayer Ag, 5090 Leverkusen Herstellung von Saccharase-Inhibitoren
DE2209833C3 (de) * 1972-03-01 1978-06-01 Bayer Ag, 5090 Leverkusen Herstellung eines Amylaseinhibitors
US4010258A (en) 1974-03-15 1977-03-01 Ajinomoto Co., Inc. Microbial amylase inhibitor and preparation thereof with the use of streptomyces diasticus var. amylostaticus
FR2338707A1 (fr) * 1976-01-22 1977-08-19 Rhone Poulenc Ind Nouvel inhibiteur de glyco-hydrolases et sa preparation par culture d'un streptomyces
DE2716050A1 (de) * 1977-04-09 1978-10-19 Hoechst Ag Alpha-amylase-inhibitor aus einem streptomyceten und verfahren zu seiner gewinnung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2120073A1 (fr) * 1970-12-28 1972-08-11 Bayer Ag
JPS5259475A (en) * 1975-11-07 1977-05-16 Hitachi Ltd Palletizer for mixed transportation

Also Published As

Publication number Publication date
DE2701890A1 (de) 1978-07-27
FR2378041B1 (fr) 1980-07-04
ATA35578A (de) 1981-02-15
DE2701890C2 (de) 1983-08-04
CA1105404A (fr) 1981-07-21
NL7800630A (nl) 1978-07-21
US4226764A (en) 1980-10-07
ES465940A1 (es) 1978-09-16
JPS6236040B2 (fr) 1987-08-05
JPS5390201A (en) 1978-08-08
US4339436A (en) 1982-07-13
US4282318A (en) 1981-08-04
BE863089A (fr) 1978-07-19
AT363891B (de) 1981-09-10
GB1599372A (en) 1981-09-30

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