ES8400489A1 - Un metodo para la preparacion de 2-hidroxi-aclacinomicinas a, b y n. - Google Patents
Un metodo para la preparacion de 2-hidroxi-aclacinomicinas a, b y n.Info
- Publication number
- ES8400489A1 ES8400489A1 ES514892A ES514892A ES8400489A1 ES 8400489 A1 ES8400489 A1 ES 8400489A1 ES 514892 A ES514892 A ES 514892A ES 514892 A ES514892 A ES 514892A ES 8400489 A1 ES8400489 A1 ES 8400489A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- anthracycline antibiotics
- anthracycline
- hydroxyaclacinomycins
- hydroxyaclacinomycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 2-ACLACINOMICINAS A, B Y N, DE FORMULA (I), EN LA QUE R ES UN RADICAL DE FORMULA (II), (III) O (IV) PARA LA 2-HIDROCIACLACIONOMICINA A, B O M, RESPECTIVAMENTE.CONSISTE EN EL CULTIVO DE LA CEPA STREPTOMYCES GALILAEUS A-862, CAPAZ DE PRODUCIR LOS COMPUESTOS DE ANTRACIDINA, EN UN MEDIO NUTRIENTE QUE CONTIENE CONPUESTOS DE NITROGENO Y FOSFORO ASIMILABLES Y COMPUESTOS INORGANICOS; SEGUIDO DE LA SEPARACION DE LOS COMPUESTOS OBTENIDOS A PARTIR DEL CALDO DE CULTIVO SIGUIENDO METODOS CONVENCIONALES.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICASPOR SU ACTIVIDAD ANTITUMORAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12582681A JPS5826895A (ja) | 1981-08-11 | 1981-08-11 | 2‐ヒドロキシアクラシノマイシンb |
JP10725682A JPS58224698A (ja) | 1982-06-21 | 1982-06-21 | 2−ヒドロキシアクラシノマイシンa及びnの製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8400489A1 true ES8400489A1 (es) | 1983-10-16 |
ES514892A0 ES514892A0 (es) | 1983-10-16 |
Family
ID=26447294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514892A Granted ES514892A0 (es) | 1981-08-11 | 1982-08-10 | Un metodo para la preparacion de 2-hidroxi-aclacinomicinas a, b y n. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4474945A (es) |
EP (1) | EP0072974B1 (es) |
CA (1) | CA1187434A (es) |
DE (1) | DE3266843D1 (es) |
DK (1) | DK161338C (es) |
ES (1) | ES514892A0 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5982395A (ja) * | 1982-11-02 | 1984-05-12 | Microbial Chem Res Found | アントラサイクリン化合物、その製造法およびその用途 |
JPS59148795A (ja) * | 1983-02-08 | 1984-08-25 | Microbial Chem Res Found | アントラサイクリン化合物、その製造法およびその用途 |
IE58981B1 (en) * | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
US4977084A (en) * | 1989-02-16 | 1990-12-11 | Board Of Trustees Operating Michigan State University | Production, isolation, and identification of novel antifungal compounds |
CN108864221B (zh) * | 2018-06-08 | 2022-04-01 | 中国科学院上海有机化学研究所 | 阿克拉霉素类似物及其制法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4204038A (en) * | 1976-04-07 | 1980-05-20 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Process for preparing antibiotics MA 144-M1 and MA 144-M2 |
JPS52136159A (en) * | 1976-04-07 | 1977-11-14 | Microbial Chem Res Found | Anti/malignanttumor containing the same as active ingredients |
US4309503A (en) * | 1978-02-09 | 1982-01-05 | Farmitalia Carlo Erba S.P.A. | Preparation of 11-deoxy anthracycline antibiotics |
ZA802929B (en) * | 1979-05-22 | 1981-05-27 | Hoffmann La Roche | Novel tetracyclic compounds and process for the preparation thereof |
DE3071391D1 (en) * | 1979-09-07 | 1986-03-13 | Sanraku Ocean Co | 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same |
JPS5731696A (en) * | 1980-08-01 | 1982-02-20 | Sanraku Inc | Anthracycline derivative |
JPS5756494A (en) * | 1980-09-22 | 1982-04-05 | Microbial Chem Res Found | New anthracyclin derivative |
DE3164574D1 (en) * | 1980-10-27 | 1984-08-09 | Hoffmann La Roche | Process for aclacinomycins and microorganism used therein |
ATE11142T1 (de) * | 1980-10-27 | 1985-01-15 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Herstellung von anthracyclinglycosiden. |
-
1982
- 1982-08-05 CA CA000408759A patent/CA1187434A/en not_active Expired
- 1982-08-06 US US06/405,917 patent/US4474945A/en not_active Expired - Lifetime
- 1982-08-10 ES ES514892A patent/ES514892A0/es active Granted
- 1982-08-10 DK DK358882A patent/DK161338C/da not_active IP Right Cessation
- 1982-08-11 DE DE8282107295T patent/DE3266843D1/de not_active Expired
- 1982-08-11 EP EP82107295A patent/EP0072974B1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0072974B1 (en) | 1985-10-09 |
DK358882A (da) | 1983-02-12 |
EP0072974A1 (en) | 1983-03-02 |
DK161338B (da) | 1991-06-24 |
US4474945A (en) | 1984-10-02 |
ES514892A0 (es) | 1983-10-16 |
CA1187434A (en) | 1985-05-21 |
DE3266843D1 (en) | 1985-11-14 |
DK161338C (da) | 1992-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |