ES8205018A1 - Un procedimiento para la preparacion de tilactona o un esterderivado de la misma - Google Patents

Un procedimiento para la preparacion de tilactona o un esterderivado de la misma

Info

Publication number
ES8205018A1
ES8205018A1 ES503565A ES503565A ES8205018A1 ES 8205018 A1 ES8205018 A1 ES 8205018A1 ES 503565 A ES503565 A ES 503565A ES 503565 A ES503565 A ES 503565A ES 8205018 A1 ES8205018 A1 ES 8205018A1
Authority
ES
Spain
Prior art keywords
preparing
macrolide
tylactone
dideoxytylonolide
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503565A
Other languages
English (en)
Other versions
ES503565A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8205018A1 publication Critical patent/ES8205018A1/es
Publication of ES503565A0 publication Critical patent/ES503565A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/896—Streptomyces fradiae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE TILACTONA O ESTER DERIVADO DE LA MISMA. CONSISTE EN CULTIVAR STREPTOMYCES FRADIEAE NRRL 12188/ UN MUTANTE O RECOMBINANTE DEL MISMO PRODUCTOR DE TILACTONA EN UN MEDIO DE CULTIVO QUE CONTIENE FUENTES ASIMILABLES DE CARBONO, NITROGENO Y SALES INORGANICAS BAJO CONDICIONES DE FERMENTACION AEROBIA SUMERGIDA. SE OBTIENE TILACTONA QUE OPCIONALMENTE SE ESTERIFICA. LA PRODUCCION DE TILACTONA PUEDE SEGUIRSE DURANTE LA FERMENTACION MEDIANTE EL ANALISIS DE MUESTRAS DE CALDO UTILIZANDO CROMATOGRAFIA LIQUIDA DE AKTO RENDIMIENTO CON UN SISTEMA DE DETECCION U V. LA TILACTONA PUEDE SER RECUPERADA POR MEDIO DE FERMENTACION POR METODOS HABITUALES, TALES COMO EXTRACCION TANTO DEL CALDO FILTRADO COMO DE LA TORTA MICELIAL, UN MUTAGENO TIPICO EMPLEADO ES LA N-METIL-N''-NIDRO-NITRO-SOGUANIDINA.
ES503565A 1980-07-02 1981-06-30 Un procedimiento para la preparacion de tilactona o un esterderivado de la misma Granted ES503565A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/162,977 US4366247A (en) 1980-07-02 1980-07-02 Process for preparing tylactone

Publications (2)

Publication Number Publication Date
ES8205018A1 true ES8205018A1 (es) 1982-05-16
ES503565A0 ES503565A0 (es) 1982-05-16

Family

ID=22587920

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503565A Granted ES503565A0 (es) 1980-07-02 1981-06-30 Un procedimiento para la preparacion de tilactona o un esterderivado de la misma

Country Status (24)

Country Link
US (1) US4366247A (es)
EP (1) EP0043280B1 (es)
JP (1) JPS5743692A (es)
KR (1) KR840001954B1 (es)
AU (1) AU7238581A (es)
BG (1) BG35749A3 (es)
CA (1) CA1171009A (es)
CS (1) CS221839B2 (es)
DD (1) DD202047A5 (es)
DE (1) DE3162648D1 (es)
DK (1) DK292681A (es)
ES (1) ES503565A0 (es)
FI (1) FI812065L (es)
GB (1) GB2079279B (es)
GR (1) GR74938B (es)
HU (1) HU189515B (es)
IE (1) IE51361B1 (es)
IL (1) IL63221A (es)
NZ (1) NZ197585A (es)
PL (1) PL231943A1 (es)
PT (1) PT73288B (es)
SU (1) SU1069631A3 (es)
YU (1) YU162181A (es)
ZA (1) ZA814463B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423148A (en) * 1982-07-02 1983-12-27 Eli Lilly And Company Process for producing 20-dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
JPS59181294A (ja) * 1983-03-30 1984-10-15 Satoshi Omura 抗生物質ｐｔｌ−４４８とその誘導体およびそれらの製造方法
US5284757A (en) * 1989-01-12 1994-02-08 Ajinomoto Company, Inc. Process for producing l-arginine by fermentation with brevibacterium or corynebacterium
US5698420A (en) * 1995-12-05 1997-12-16 Pfizer Inc. Preparation of 4-deoxy-O-mycaminosyltylonolide
CA2197524A1 (en) * 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
KR100914251B1 (ko) 2007-06-27 2009-08-26 이화여자대학교 산학협력단 신규한 올리보실 틸락톤 및 그 제조 방법
MD1180Z (ro) * 2017-03-02 2018-03-31 Институт Физиологии И Санокреатологии Академии Наук Молдовы Procedeu de stimulare a formării reflexelor condiţionate în perioada diminuării funcţiilor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178341A (en) * 1960-06-27 1965-04-13 Lilly Co Eli Antibiotics tylosin and desmycosin and derivatives thereof
US3326759A (en) * 1962-07-19 1967-06-20 Lilly Co Eli Antibiotics macrocin and lactenocin
US3344024A (en) * 1963-04-17 1967-09-26 American Cyanamid Co Antibiotic am-684 and method of production
BE667952A (es) * 1964-08-05
US4161523A (en) * 1972-11-15 1979-07-17 Schering Corporation Rosamicin esters, acid addition salts and methods for production thereof
GB1587685A (en) * 1977-03-09 1981-04-08 Microbial Chem Res Found Macrolactone derivatives and their production

Also Published As

Publication number Publication date
CA1171009A (en) 1984-07-17
DK292681A (da) 1982-01-03
IE811462L (en) 1982-01-02
HU189515B (en) 1986-07-28
SU1069631A3 (ru) 1984-01-23
CS221839B2 (en) 1983-04-29
EP0043280B1 (en) 1984-03-14
DD202047A5 (de) 1983-08-24
IL63221A0 (en) 1981-10-30
EP0043280A1 (en) 1982-01-06
NZ197585A (en) 1983-11-30
AU7238581A (en) 1982-01-07
KR840001954B1 (ko) 1984-10-26
PL231943A1 (es) 1982-10-11
US4366247A (en) 1982-12-28
FI812065L (fi) 1982-01-03
IE51361B1 (en) 1986-12-10
KR830006425A (ko) 1983-09-24
GB2079279B (en) 1984-08-22
GR74938B (es) 1984-07-12
IL63221A (en) 1985-03-31
JPS5743692A (en) 1982-03-11
PT73288B (en) 1982-07-22
PT73288A (en) 1981-07-01
GB2079279A (en) 1982-01-20
ES503565A0 (es) 1982-05-16
YU162181A (en) 1983-09-30
ZA814463B (en) 1983-02-23
BG35749A3 (en) 1984-06-15
DE3162648D1 (en) 1984-04-19

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