KR830006425A - 매크로리드의 제조방법 - Google Patents
매크로리드의 제조방법 Download PDFInfo
- Publication number
- KR830006425A KR830006425A KR1019810002384A KR810002384A KR830006425A KR 830006425 A KR830006425 A KR 830006425A KR 1019810002384 A KR1019810002384 A KR 1019810002384A KR 810002384 A KR810002384 A KR 810002384A KR 830006425 A KR830006425 A KR 830006425A
- Authority
- KR
- South Korea
- Prior art keywords
- manufacturing
- tylactone
- nitrogen
- carbon
- inorganic salts
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- YJSXTLYNFBFHAT-UHFFFAOYSA-N Protylonolide Natural products CCC1CC(C)C(=O)C=CC(C)=CC(C)C(CC)OC(=O)CC(O)C(C)C1O YJSXTLYNFBFHAT-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YJSXTLYNFBFHAT-HJOMEYPASA-N tylactone Chemical compound CC[C@H]1C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](C)[C@@H](CC)OC(=O)C[C@@H](O)[C@H](C)[C@H]1O YJSXTLYNFBFHAT-HJOMEYPASA-N 0.000 claims 2
- 241000187747 Streptomyces Species 0.000 claims 1
- 241000187438 Streptomyces fradiae Species 0.000 claims 1
- 238000010564 aerobic fermentation Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000007654 immersion Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/54—Streptomyces fradiae
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/896—Streptomyces fradiae
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 클로로포름 중에서의 타이락톤의 적외선 흡수 스펙트럼.
Claims (2)
- 스트렙토마이세스 프라디아에(Streptomyces fradiae) NRRL 12188 또는 이의 타이락톤 생산변이체 또는 재결합체를 액침 호기성 발효조건하에 탄소, 질소 및 무기염의 동화원이 함유된 배지내에서 배양하여 타이락톤을 생산한 다음 이어서 임의로 에스테르화함을 특징으로 하여 타이락톤 또는 이의 에스테르유도체의 제조 방법.
- 스트렙토마이세스 프라디아에 NRRL 12188 및 탄소, 질소 및 무기염의 동화원을 함유함을 특징으로 하는 배양배지.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US162977 | 1980-07-02 | ||
US06/162,977 US4366247A (en) | 1980-07-02 | 1980-07-02 | Process for preparing tylactone |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830006425A true KR830006425A (ko) | 1983-09-24 |
KR840001954B1 KR840001954B1 (ko) | 1984-10-26 |
Family
ID=22587920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810002384A KR840001954B1 (ko) | 1980-07-02 | 1981-07-01 | 매크로리드의 제조방법 |
Country Status (24)
Country | Link |
---|---|
US (1) | US4366247A (ko) |
EP (1) | EP0043280B1 (ko) |
JP (1) | JPS5743692A (ko) |
KR (1) | KR840001954B1 (ko) |
AU (1) | AU7238581A (ko) |
BG (1) | BG35749A3 (ko) |
CA (1) | CA1171009A (ko) |
CS (1) | CS221839B2 (ko) |
DD (1) | DD202047A5 (ko) |
DE (1) | DE3162648D1 (ko) |
DK (1) | DK292681A (ko) |
ES (1) | ES8205018A1 (ko) |
FI (1) | FI812065L (ko) |
GB (1) | GB2079279B (ko) |
GR (1) | GR74938B (ko) |
HU (1) | HU189515B (ko) |
IE (1) | IE51361B1 (ko) |
IL (1) | IL63221A (ko) |
NZ (1) | NZ197585A (ko) |
PL (1) | PL231943A1 (ko) |
PT (1) | PT73288B (ko) |
SU (1) | SU1069631A3 (ko) |
YU (1) | YU162181A (ko) |
ZA (1) | ZA814463B (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4423148A (en) * | 1982-07-02 | 1983-12-27 | Eli Lilly And Company | Process for producing 20-dihydro-20-deoxy-23-de(mycinosyloxy)tylosin |
JPS59181294A (ja) * | 1983-03-30 | 1984-10-15 | Satoshi Omura | 抗生物質ptl−448とその誘導体およびそれらの製造方法 |
US5284757A (en) * | 1989-01-12 | 1994-02-08 | Ajinomoto Company, Inc. | Process for producing l-arginine by fermentation with brevibacterium or corynebacterium |
US5698420A (en) * | 1995-12-05 | 1997-12-16 | Pfizer Inc. | Preparation of 4-deoxy-O-mycaminosyltylonolide |
CA2197524A1 (en) * | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
KR100914251B1 (ko) | 2007-06-27 | 2009-08-26 | 이화여자대학교 산학협력단 | 신규한 올리보실 틸락톤 및 그 제조 방법 |
MD1180Z (ro) * | 2017-03-02 | 2018-03-31 | Институт Физиологии И Санокреатологии Академии Наук Молдовы | Procedeu de stimulare a formării reflexelor condiţionate în perioada diminuării funcţiilor |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3178341A (en) * | 1960-06-27 | 1965-04-13 | Lilly Co Eli | Antibiotics tylosin and desmycosin and derivatives thereof |
US3326759A (en) * | 1962-07-19 | 1967-06-20 | Lilly Co Eli | Antibiotics macrocin and lactenocin |
US3344024A (en) * | 1963-04-17 | 1967-09-26 | American Cyanamid Co | Antibiotic am-684 and method of production |
BE667952A (ko) * | 1964-08-05 | |||
US4161523A (en) * | 1972-11-15 | 1979-07-17 | Schering Corporation | Rosamicin esters, acid addition salts and methods for production thereof |
GB1587685A (en) * | 1977-03-09 | 1981-04-08 | Microbial Chem Res Found | Macrolactone derivatives and their production |
-
1980
- 1980-07-02 US US06/162,977 patent/US4366247A/en not_active Expired - Lifetime
-
1981
- 1981-06-30 CA CA000380946A patent/CA1171009A/en not_active Expired
- 1981-06-30 IE IE1462/81A patent/IE51361B1/en not_active IP Right Cessation
- 1981-06-30 SU SU813302650A patent/SU1069631A3/ru active
- 1981-06-30 GR GR62388A patent/GR74938B/el unknown
- 1981-06-30 EP EP81302964A patent/EP0043280B1/en not_active Expired
- 1981-06-30 YU YU01621/81A patent/YU162181A/xx unknown
- 1981-06-30 PL PL81231943A patent/PL231943A1/xx unknown
- 1981-06-30 NZ NZ197585A patent/NZ197585A/xx unknown
- 1981-06-30 GB GB8120169A patent/GB2079279B/en not_active Expired
- 1981-06-30 DE DE8181302964T patent/DE3162648D1/de not_active Expired
- 1981-06-30 ES ES503565A patent/ES8205018A1/es not_active Expired
- 1981-06-30 AU AU72385/81A patent/AU7238581A/en not_active Abandoned
- 1981-06-30 PT PT73288A patent/PT73288B/pt unknown
- 1981-07-01 DK DK292681A patent/DK292681A/da not_active Application Discontinuation
- 1981-07-01 FI FI812065A patent/FI812065L/fi not_active Application Discontinuation
- 1981-07-01 CS CS815078A patent/CS221839B2/cs unknown
- 1981-07-01 KR KR1019810002384A patent/KR840001954B1/ko active
- 1981-07-01 JP JP56103870A patent/JPS5743692A/ja active Pending
- 1981-07-01 ZA ZA814463A patent/ZA814463B/xx unknown
- 1981-07-01 HU HU811930A patent/HU189515B/hu not_active IP Right Cessation
- 1981-07-02 BG BG8152726A patent/BG35749A3/xx unknown
- 1981-07-02 IL IL63221A patent/IL63221A/xx unknown
- 1981-07-02 DD DD81231394A patent/DD202047A5/de unknown
Also Published As
Publication number | Publication date |
---|---|
EP0043280B1 (en) | 1984-03-14 |
YU162181A (en) | 1983-09-30 |
PT73288A (en) | 1981-07-01 |
CA1171009A (en) | 1984-07-17 |
AU7238581A (en) | 1982-01-07 |
EP0043280A1 (en) | 1982-01-06 |
GB2079279A (en) | 1982-01-20 |
NZ197585A (en) | 1983-11-30 |
ES503565A0 (es) | 1982-05-16 |
IL63221A0 (en) | 1981-10-30 |
ES8205018A1 (es) | 1982-05-16 |
US4366247A (en) | 1982-12-28 |
FI812065L (fi) | 1982-01-03 |
DD202047A5 (de) | 1983-08-24 |
KR840001954B1 (ko) | 1984-10-26 |
IE51361B1 (en) | 1986-12-10 |
DK292681A (da) | 1982-01-03 |
PL231943A1 (ko) | 1982-10-11 |
GB2079279B (en) | 1984-08-22 |
ZA814463B (en) | 1983-02-23 |
GR74938B (ko) | 1984-07-12 |
JPS5743692A (en) | 1982-03-11 |
SU1069631A3 (ru) | 1984-01-23 |
DE3162648D1 (en) | 1984-04-19 |
CS221839B2 (en) | 1983-04-29 |
PT73288B (en) | 1982-07-22 |
IE811462L (en) | 1982-01-02 |
HU189515B (en) | 1986-07-28 |
IL63221A (en) | 1985-03-31 |
BG35749A3 (en) | 1984-06-15 |
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