KR830007833A - 마크로라이드 항생물질의 제조방법 - Google Patents

마크로라이드 항생물질의 제조방법 Download PDF

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KR830007833A
KR830007833A KR1019810004342A KR810004342A KR830007833A KR 830007833 A KR830007833 A KR 830007833A KR 1019810004342 A KR1019810004342 A KR 1019810004342A KR 810004342 A KR810004342 A KR 810004342A KR 830007833 A KR830007833 A KR 830007833A
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macrolide
manufacturing
macrolides
hydrogen
general formula
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KR1019810004342A
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KR850001666B1 (ko
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헨리발쯔 리차드
앤드류 키스트 허버트
무리엘 윌드 제느
토마스 세노 유젠
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아더 알. 웨일
일라이 릴리 앤드 캄파니
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Publication of KR850001666B1 publication Critical patent/KR850001666B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/896—Streptomyces fradiae

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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

마크로라이드 항생물질의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도 DH-DO-DMT(유리염기)클로로포롬내에서의 ir 흡수 스펙트럼.
제2도 DH-DO-OMT(유기염기)클로로포롬내에서의 ir 흡수 스펙트럼.

Claims (1)

  1. 탄소원, 질소원 및 뮈염등의 동화원이 들어있는 배양배지내에서 스트랩토마이세스 푸라디에 (Strept omyces fradiae) ATCC 31733를 호기성 심부배양을 시켜 실질적인 양의 항생물질을 생산할 정도로 배양시키거나 일반식(I)의 마크로라이드로부터 마크로실그룹을 제거하여 Q 가수소인 일반식(I)의 마크로 라이드를 제공하고 필요시 임의로 상기에서 형성된 일반식(I)의 마크로라이드중 어느것을 에스테르화 또는 염화시켜서 일반식(I)의 마크로라이드 또는 약학적으로 무독한 그의 에스테르 또는 그의 산부가염을 제조하는 방법.
    상기식에서
    Q는 수소 또는
    ※ 참고사항 : 최초출원에 내용에 의하여 공개하는 것임.
KR1019810004342A 1980-11-10 1981-11-10 마크로라이드 항생물질의 제조방법 KR850001666B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US205,539 1980-11-10
US06/205,539 US4304856A (en) 1980-11-10 1980-11-10 Process for producing 20-dihydro-20-deoxy-23-demycinosyltylosin
US205539 1998-12-03

Publications (2)

Publication Number Publication Date
KR830007833A true KR830007833A (ko) 1983-11-07
KR850001666B1 KR850001666B1 (ko) 1985-11-13

Family

ID=22762621

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004342A KR850001666B1 (ko) 1980-11-10 1981-11-10 마크로라이드 항생물질의 제조방법

Country Status (22)

Country Link
US (1) US4304856A (ko)
EP (1) EP0052005B1 (ko)
JP (1) JPS57108097A (ko)
KR (1) KR850001666B1 (ko)
AR (1) AR227563A1 (ko)
AU (1) AU7731381A (ko)
BG (1) BG36939A3 (ko)
CA (1) CA1169374A (ko)
CS (1) CS236663B2 (ko)
DD (1) DD202032A5 (ko)
DE (1) DE3168693D1 (ko)
DK (1) DK494381A (ko)
FI (1) FI813527L (ko)
GB (1) GB2086902B (ko)
GR (1) GR75386B (ko)
HU (1) HU190360B (ko)
IE (1) IE51826B1 (ko)
IL (1) IL64240A (ko)
PH (1) PH17375A (ko)
PL (1) PL233747A1 (ko)
PT (1) PT73947B (ko)
ZA (1) ZA817718B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419508A (en) * 1980-11-10 1983-12-06 Eli Lilly And Company 20-Dihydro-20-deoxy-23-demycinosyltylosin and process for its production
AU551142B2 (en) * 1981-07-09 1986-04-17 Zaidan Hojin Biseibutsu Kagaku Kenkyukai Tylosin derivatives
US4423148A (en) * 1982-07-02 1983-12-27 Eli Lilly And Company Process for producing 20-dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US4528369A (en) * 1982-07-02 1985-07-09 Eli Lilly And Company 20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US4452784A (en) * 1982-07-19 1984-06-05 Eli Lilly And Company C-23-Modified derivatives of DMT
US4443436A (en) * 1982-09-13 1984-04-17 Eli Lilly And Company C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin
US4629786A (en) * 1983-02-28 1986-12-16 Eli Lilly And Company C-20- and C-23 modified macrolide derivatives
US4468511A (en) * 1983-02-28 1984-08-28 Eli Lilly And Company C-20- And C-23-Modified macrolide derivatives
IL71032A0 (en) * 1983-02-28 1984-05-31 Lilly Co Eli C-20 and c-23-modified macrolide derivatives
ATE151767T1 (de) * 1993-07-15 1997-05-15 Pfizer Amid-derivate von 16-gliedrige heterocyclen als antibiotische macrolide
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178341A (en) * 1960-06-27 1965-04-13 Lilly Co Eli Antibiotics tylosin and desmycosin and derivatives thereof
US3326759A (en) * 1962-07-19 1967-06-20 Lilly Co Eli Antibiotics macrocin and lactenocin
US3344024A (en) * 1963-04-17 1967-09-26 American Cyanamid Co Antibiotic am-684 and method of production
BE667952A (ko) * 1964-08-05
US4161523A (en) * 1972-11-15 1979-07-17 Schering Corporation Rosamicin esters, acid addition salts and methods for production thereof
US4056616A (en) * 1976-03-05 1977-11-01 Schering Corporation Rosamicin derivatives and method of using same
GB1587685A (en) * 1977-03-09 1981-04-08 Microbial Chem Res Found Macrolactone derivatives and their production
US4252898A (en) * 1979-05-23 1981-02-24 Eli Lilly And Company Antibiotics A6888C and A6888X
NL8004922A (nl) * 1979-09-19 1981-03-23 Toyo Jozo Kk Deformyltylosinederivaten.

Also Published As

Publication number Publication date
CS236663B2 (en) 1985-05-15
IL64240A (en) 1985-08-30
EP0052005A1 (en) 1982-05-19
EP0052005B1 (en) 1985-01-30
FI813527L (fi) 1982-05-11
DD202032A5 (de) 1983-08-24
BG36939A3 (en) 1985-02-15
GR75386B (ko) 1984-07-13
KR850001666B1 (ko) 1985-11-13
IE812616L (en) 1982-05-10
GB2086902B (en) 1985-06-26
GB2086902A (en) 1982-05-19
ZA817718B (en) 1982-10-27
IL64240A0 (en) 1982-02-28
AU7731381A (en) 1982-05-20
DK494381A (da) 1982-05-11
PH17375A (en) 1984-08-06
PL233747A1 (ko) 1982-11-22
JPS57108097A (en) 1982-07-05
CA1169374A (en) 1984-06-19
DE3168693D1 (en) 1985-03-14
PT73947B (en) 1983-11-30
IE51826B1 (en) 1987-04-01
HU190360B (en) 1986-08-28
US4304856A (en) 1981-12-08
AR227563A1 (es) 1982-11-15
PT73947A (en) 1981-12-01

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