KR830006429A - 탈(마이시노실옥시)타일로신의 제조방법 - Google Patents

탈(마이시노실옥시)타일로신의 제조방법 Download PDF

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Publication number
KR830006429A
KR830006429A KR1019810002107A KR810002107A KR830006429A KR 830006429 A KR830006429 A KR 830006429A KR 1019810002107 A KR1019810002107 A KR 1019810002107A KR 810002107 A KR810002107 A KR 810002107A KR 830006429 A KR830006429 A KR 830006429A
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KR
South Korea
Prior art keywords
tyrosine
preparing
talmyosinyl
substituted
mycinosyloxy
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KR1019810002107A
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English (en)
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KR840001956B1 (ko
Inventor
헨리 발츠 리차드
뮤리엘 와일드 진
토마스 세노 유진
앤드류 커스트 허버트
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아더 알, 웨일
일라이 릴리 앤드 캄파니
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Publication of KR830006429A publication Critical patent/KR830006429A/ko
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Publication of KR840001956B1 publication Critical patent/KR840001956B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음

Description

탈(마이시노실옥시)타일로신의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
도면은 클로로포름중의 DMT 유리염기의 적외부 흡수 스펙트럼을 나타낸다.

Claims (3)

  1. 스트렙토마이세스 프라디아에 NRRL 12170을 심부 호기성 조건하에 상당 수준의 항생물질 활성이 생성될 때까지 배양시켜서 마크롤라이드를 수득하거나 23-탈마이시노실타일로신을 화학적 환원제로 환원시켜서 Q가 -CH2OH인 마크롤라이드를 형성하고, 필요하다면 염화 또는 에스테르화시켜서 염 또는 에스테르를 형성함을 특징으로 하여 다음 일반식(Ⅰ)의 마크룰라이드) 그의 약학적으로 무독한 염, 또는 아실에스테르를 제조하는 방법.
    상기식에서
    Q는 -CH2OH 또는 -CHO 이다.
    (단 분자의 3-위치는 0-아세틸기로 치환될 때 4"-위치는 0-이소발로릴기로 치환될 수 없다).
  2. 23-탈마이시노실 타일로신을 제조하는 특허청구 범위 1에 따르는 방법.
  3. 20-디하이드로-23-탈마이시노실타일로신을 제조하는 특허청구범위 1에 따르는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810002107A 1980-06-12 1981-06-12 데(마이시노실옥시)타일로신의 제조방법 KR840001956B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/156,854 US4321361A (en) 1980-06-12 1980-06-12 Demycinosyltylosin and process for its production
US156854 1980-06-12
US06/156,855 US4321362A (en) 1980-06-12 1980-06-12 De(mycinosyloxy)tylosin and process for its production

Publications (2)

Publication Number Publication Date
KR830006429A true KR830006429A (ko) 1983-09-24
KR840001956B1 KR840001956B1 (ko) 1984-10-26

Family

ID=26853578

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810002107A KR840001956B1 (ko) 1980-06-12 1981-06-12 데(마이시노실옥시)타일로신의 제조방법

Country Status (26)

Country Link
US (2) US4321362A (ko)
EP (1) EP0042250B1 (ko)
JP (1) JPS5731699A (ko)
KR (1) KR840001956B1 (ko)
AR (2) AR226899A1 (ko)
AU (1) AU544988B2 (ko)
CA (1) CA1172189A (ko)
CS (1) CS225841B2 (ko)
DD (1) DD159644A5 (ko)
DE (1) DE3162500D1 (ko)
DK (1) DK255681A (ko)
ES (1) ES502980A0 (ko)
FI (1) FI811826L (ko)
GB (1) GB2077731B (ko)
GR (1) GR75277B (ko)
HU (1) HU189512B (ko)
IE (1) IE51614B1 (ko)
IL (1) IL63075A (ko)
NZ (1) NZ197359A (ko)
PH (1) PH16171A (ko)
PL (2) PL131731B1 (ko)
PT (1) PT73165B (ko)
RO (1) RO81016A (ko)
SU (1) SU1151218A3 (ko)
YU (1) YU144381A (ko)
ZA (1) ZA813579B (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486584A (en) * 1980-07-15 1984-12-04 Eli Lilly And Company Demethylmacrocin compounds and derivatives thereof
US4419508A (en) * 1980-11-10 1983-12-06 Eli Lilly And Company 20-Dihydro-20-deoxy-23-demycinosyltylosin and process for its production
US4487923A (en) * 1981-12-14 1984-12-11 Eli Lilly And Company Method of preparing 23-monoesters of OMT and DMT
US4396613A (en) * 1981-12-14 1983-08-02 Eli Lilly And Company 23-Ester derivatives of DMT and method of using same
US4401660A (en) * 1981-12-14 1983-08-30 Eli Lilly And Company Ester derivatives of 5-O-mycaminosyl tylonolide and method of using same
US4436733A (en) 1982-03-03 1984-03-13 Eli Lilly And Company 4"- And 3-ester derivatives of DMT and DMOT
US4435388A (en) 1982-06-10 1984-03-06 Schering Corporation Tylosin 20-imino-20-deoxo-4"-acyl derivatives, pharmaceutical compositions and method of use
JPS58219197A (ja) * 1982-06-15 1983-12-20 Sanraku Inc マクロライド系抗生物質の誘導体
US4436729A (en) 1982-06-30 1984-03-13 Schering Corporation 23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use
US4528369A (en) * 1982-07-02 1985-07-09 Eli Lilly And Company 20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin
US4452784A (en) * 1982-07-19 1984-06-05 Eli Lilly And Company C-23-Modified derivatives of DMT
US4459290A (en) * 1982-07-19 1984-07-10 Eli Lilly And Company C-23-Modified derivatives of OMT, pharmaceutical compositions and method of use
US4443436A (en) 1982-09-13 1984-04-17 Eli Lilly And Company C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin
US4820695A (en) * 1982-09-13 1989-04-11 Eli Lilly And Company C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
IL71032A0 (en) * 1983-02-28 1984-05-31 Lilly Co Eli C-20 and c-23-modified macrolide derivatives
US4468511A (en) * 1983-02-28 1984-08-28 Eli Lilly And Company C-20- And C-23-Modified macrolide derivatives
US4629786A (en) * 1983-02-28 1986-12-16 Eli Lilly And Company C-20- and C-23 modified macrolide derivatives
JPS59181294A (ja) * 1983-03-30 1984-10-15 Satoshi Omura 抗生物質ｐｔｌ−４４８とその誘導体およびそれらの製造方法
US4851518A (en) * 1985-12-23 1989-07-25 Schering Corporation Di and tri-O-acetyl-"O-iso-valeryl-23-O-demycinosyl tylosins, hydrazone derivatives thereof and processes for their preparation
US4808575A (en) * 1986-06-23 1989-02-28 Schering Corporation 12,13-oxoderivatives of macrolides
US4962146A (en) * 1987-04-29 1990-10-09 Schering Corporation 3-O-glycosyl 16-membered macrolide antibacterials and related derivatives
JPH01230559A (ja) * 1988-03-11 1989-09-14 Sagami Chem Res Center ５−置換メチリデンヒダントイン誘導体
IL98599A (en) * 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them
US7247617B2 (en) * 2004-07-13 2007-07-24 Kosan Biosciences Incorporated Sixteen-member macrolide antiinfective agents
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US3178341A (en) * 1960-06-27 1965-04-13 Lilly Co Eli Antibiotics tylosin and desmycosin and derivatives thereof
US3326759A (en) * 1962-07-19 1967-06-20 Lilly Co Eli Antibiotics macrocin and lactenocin
US3344024A (en) * 1963-04-17 1967-09-26 American Cyanamid Co Antibiotic am-684 and method of production
BE667952A (ko) * 1964-08-05
US4161523A (en) * 1972-11-15 1979-07-17 Schering Corporation Rosamicin esters, acid addition salts and methods for production thereof
US3923784A (en) * 1973-09-10 1975-12-02 Hoffmann La Roche Erythromycin a derivatives
YU35363B (en) * 1974-01-14 1980-12-31 Pliva Zagreb Process for obtaining n-(benzene-sulfonyl)-5-0desosaminyl-erythromycilamine derivatives
JPS52139088A (en) * 1976-05-15 1977-11-19 Sanraku Inc Antibiotics tyrocin derivatives and their preparation
US4056616A (en) * 1976-03-05 1977-11-01 Schering Corporation Rosamicin derivatives and method of using same
JPS5315160A (en) * 1976-07-27 1978-02-10 Nippon Steel Corp Sensitivity controller of self-scan image sensor in thermal radiating object measuring apparatus
GB1587685A (en) * 1977-03-09 1981-04-08 Microbial Chem Res Found Macrolactone derivatives and their production
US4205163A (en) * 1977-11-08 1980-05-27 Sanraku-Ocean Co., Ltd. Tylosin derivatives
JPS6016960B2 (ja) * 1978-09-20 1985-04-30 メルシャン株式会社 マクロライド系抗生物質ｎ−１及びその製造法

Also Published As

Publication number Publication date
AR226899A1 (es) 1982-08-31
IL63075A (en) 1984-07-31
PT73165B (en) 1982-07-16
NZ197359A (en) 1984-03-16
PL131733B1 (en) 1984-12-31
ZA813579B (en) 1983-01-26
DK255681A (da) 1981-12-13
GB2077731B (en) 1984-04-26
AU7144681A (en) 1981-12-17
IL63075A0 (en) 1981-09-13
IE51614B1 (en) 1987-01-21
HU189512B (en) 1986-07-28
EP0042250A1 (en) 1981-12-23
GB2077731A (en) 1981-12-23
JPS5731699A (en) 1982-02-20
PT73165A (en) 1981-07-01
KR840001956B1 (ko) 1984-10-26
YU144381A (en) 1983-09-30
CS225841B2 (en) 1984-02-13
ES8203962A1 (es) 1982-04-16
PL231598A1 (ko) 1982-02-15
DD159644A5 (de) 1983-03-23
DE3162500D1 (en) 1984-04-12
IE811297L (en) 1981-12-12
SU1151218A3 (ru) 1985-04-15
PL231594A1 (ko) 1982-02-15
US4321362A (en) 1982-03-23
FI811826L (fi) 1981-12-13
GR75277B (ko) 1984-07-13
US4321361A (en) 1982-03-23
PL131731B1 (en) 1984-12-31
EP0042250B1 (en) 1984-03-07
CA1172189A (en) 1984-08-07
ES502980A0 (es) 1982-04-16
PH16171A (en) 1983-07-21
AU544988B2 (en) 1985-06-27
RO81016A (ro) 1983-02-01
AR227316A1 (es) 1982-10-15

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