KR860007281A - 에리트로마이신 a 유도체의 선택적인 메틸화 방법 - Google Patents

에리트로마이신 a 유도체의 선택적인 메틸화 방법 Download PDF

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Publication number
KR860007281A
KR860007281A KR1019860001934A KR860001934A KR860007281A KR 860007281 A KR860007281 A KR 860007281A KR 1019860001934 A KR1019860001934 A KR 1019860001934A KR 860001934 A KR860001934 A KR 860001934A KR 860007281 A KR860007281 A KR 860007281A
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South Korea
Prior art keywords
derivative
compound
erythromycin
group
methylerythromycin
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Application number
KR1019860001934A
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English (en)
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KR920002142B1 (ko
Inventor
시게오 모리모또
다까시 아다끼
다까시 아다찌
도시후미 아사끼
도시후미 아사까
마사또 가시무라
요시아끼 와따나베
가오루 소따
Original Assignee
다이쇼 세이야꾸 가부시끼가이샤
우에하라쇼지
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Publication of KR860007281A publication Critical patent/KR860007281A/ko
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Publication of KR920002142B1 publication Critical patent/KR920002142B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

에리트로마이신 A 유도체의 선택적인 메틸화 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 에리트로마이신 A 9-옥심을 일반식 R-X(여기에서 R은 2-알케닐기, 벤질기 또는 치환된 벤질기이고, X는 할로겐 원자임)의 화합물과 반응시켜서 다음 일반식(Ⅰ)으로 표시되는 사급염 화합물
    (식중, R 및 X는 상기 정의한 바와 같음)을 얻고, 이 사급염 화합물을 메틸화제와 반응시켜서 6-0-메틸에리트로마이신 A 유도체를 얻은 후, 이 6-0-메틸에리트로마이신 A 유도체의 R기를 수소 첨가분해반응에 의해 제거시켜서 다음 구조식(Ⅱ)으로 표시되는 6-0-메틸에리트로마이신 A 9-옥심
    을 얻는 것을 특징으로 하는 에리트로마이신 A 유도체의 6-위치에서 히드록시기를 선택적으로 메틸화시키는 방법.
  2. 제 1 항에 있어서, R-X 화합물이 할로겐화알릴인 방법.
  3. 제 1 항에 있어서, R-X 화합물이 할로겐화벤질인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860001934A 1985-03-18 1986-03-17 에리트로마이신 a 유도체의 선택적인 메틸화 방법 KR920002142B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP53618 1985-03-18
JP5361885 1985-03-18
JP209357 1985-09-21
JP20935785 1985-09-21

Publications (2)

Publication Number Publication Date
KR860007281A true KR860007281A (ko) 1986-10-10
KR920002142B1 KR920002142B1 (ko) 1992-03-12

Family

ID=26394336

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860001934A KR920002142B1 (ko) 1985-03-18 1986-03-17 에리트로마이신 a 유도체의 선택적인 메틸화 방법

Country Status (13)

Country Link
US (1) US4670549A (ko)
EP (1) EP0195960B1 (ko)
JP (1) JPH0676432B2 (ko)
KR (1) KR920002142B1 (ko)
AU (1) AU574265B2 (ko)
CA (1) CA1234806A (ko)
DE (1) DE3661420D1 (ko)
DK (1) DK172583B1 (ko)
ES (1) ES8800689A1 (ko)
FI (1) FI80708C (ko)
GE (1) GEP19960319B (ko)
PT (1) PT82210B (ko)
SU (1) SU1468426A3 (ko)

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Also Published As

Publication number Publication date
CA1234806A (en) 1988-04-05
EP0195960A1 (en) 1986-10-01
JPH0676432B2 (ja) 1994-09-28
FI80708B (fi) 1990-03-30
FI861072A0 (fi) 1986-03-14
AU574265B2 (en) 1988-06-30
DK121586A (da) 1986-09-19
EP0195960B1 (en) 1988-12-14
PT82210B (pt) 1988-07-29
DE3661420D1 (en) 1989-01-19
GEP19960319B (en) 1996-06-24
US4670549A (en) 1987-06-02
JPS62149695A (ja) 1987-07-03
DK121586D0 (da) 1986-03-17
ES553048A0 (es) 1987-11-16
ES8800689A1 (es) 1987-11-16
AU5411086A (en) 1986-09-25
FI861072A (fi) 1986-09-19
DK172583B1 (da) 1999-02-08
SU1468426A3 (ru) 1989-03-23
PT82210A (en) 1986-04-01
FI80708C (fi) 1990-07-10
KR920002142B1 (ko) 1992-03-12

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