FI861072A - Foerfarande foer selektiv metylation av derivat av erytromycin a. - Google Patents

Foerfarande foer selektiv metylation av derivat av erytromycin a. Download PDF

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Publication number
FI861072A
FI861072A FI861072A FI861072A FI861072A FI 861072 A FI861072 A FI 861072A FI 861072 A FI861072 A FI 861072A FI 861072 A FI861072 A FI 861072A FI 861072 A FI861072 A FI 861072A
Authority
FI
Finland
Prior art keywords
metylation
erytromycin
derivat
foerfarande foer
selektiv
Prior art date
Application number
FI861072A
Other languages
English (en)
Other versions
FI80708C (fi
FI861072A0 (fi
FI80708B (fi
Inventor
Shigeo Morimoto
Takashi Adachi
Toshifumi Asaka
Masato Kashimura
Yoshiaki Watanabe
Kaoru Sota
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of FI861072A0 publication Critical patent/FI861072A0/fi
Publication of FI861072A publication Critical patent/FI861072A/fi
Application granted granted Critical
Publication of FI80708B publication Critical patent/FI80708B/fi
Publication of FI80708C publication Critical patent/FI80708C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI861072A 1985-03-18 1986-03-14 Foerfarande foer selektiv metylation av derivat av erytromycin a. FI80708C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5361885 1985-03-18
JP5361885 1985-03-18
JP20935785 1985-09-21
JP20935785 1985-09-21

Publications (4)

Publication Number Publication Date
FI861072A0 FI861072A0 (fi) 1986-03-14
FI861072A true FI861072A (fi) 1986-09-19
FI80708B FI80708B (fi) 1990-03-30
FI80708C FI80708C (fi) 1990-07-10

Family

ID=26394336

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861072A FI80708C (fi) 1985-03-18 1986-03-14 Foerfarande foer selektiv metylation av derivat av erytromycin a.

Country Status (13)

Country Link
US (1) US4670549A (fi)
EP (1) EP0195960B1 (fi)
JP (1) JPH0676432B2 (fi)
KR (1) KR920002142B1 (fi)
AU (1) AU574265B2 (fi)
CA (1) CA1234806A (fi)
DE (1) DE3661420D1 (fi)
DK (1) DK172583B1 (fi)
ES (1) ES8800689A1 (fi)
FI (1) FI80708C (fi)
GE (1) GEP19960319B (fi)
PT (1) PT82210B (fi)
SU (1) SU1468426A3 (fi)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
JPS63107994A (ja) * 1986-05-02 1988-05-12 Taisho Pharmaceut Co Ltd エリスロマイシン誘導体
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
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IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2669337B1 (fr) * 1990-11-21 1995-03-24 Roussel Uclaf Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
FR2680790B1 (fr) * 1991-08-29 1996-10-31 Roussel Uclaf Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
FR2677025B1 (fr) * 1991-05-27 1995-04-07 Roussel Uclaf Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5719272A (en) * 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5837829A (en) * 1996-04-02 1998-11-17 Abbott Laboratories 9-oximesilyl erythromycin a derivatives
US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
AU733646B2 (en) 1996-07-29 2001-05-17 Bgp Products Operations Gmbh Preparation of crystal form II of clarithromycin
AU777612B2 (en) * 1996-07-29 2004-10-21 Bgp Products Operations Gmbh Crystal form I of clarithromycin
US5945405A (en) * 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US5864023A (en) * 1997-02-13 1999-01-26 Abbott Laboratories 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) * 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
US5852180A (en) * 1997-11-17 1998-12-22 Abbott Laboratories Chemical synthesis of 6-O-alkyl erythromycin A
US5932710A (en) * 1997-12-01 1999-08-03 Abbott Laboratories Process for preparing 6-O-alkyl-9-oxime erythromycin B
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US5892008A (en) * 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
IL124084A0 (en) * 1998-04-14 1999-04-11 Chemagis Ltd Erythromycin a derivatives and methods for the preparation thereof
IL125372A0 (en) * 1998-07-15 1999-03-12 Chemagis Ltd Erythromycin derivatives and methods for the preparation thereof
CA2411293A1 (en) 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
US6420535B1 (en) 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
US6569836B2 (en) 1999-12-02 2003-05-27 Abbott Laboratories 6-O-alkyl-2-nor-2-substituted ketolide derivatives
US6627743B1 (en) 1999-12-03 2003-09-30 Abbott Laboratories 6-O-methylerythromycin A crystal form III
HUP0204091A3 (en) 1999-12-16 2003-05-28 Teva Pharma Processes for preparing clarithromycin polymorphs and novel polymorph iv and pharmaceutical composition containing them and their use
IL150698A0 (en) * 2000-01-11 2003-02-12 Teva Pharma Processes for preparing clarithromycin polymorphs
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
IL151496A0 (en) * 2000-02-29 2003-04-10 Teva Pharma Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
EP1134229B1 (en) * 2000-03-15 2005-06-15 Hanmi Pharm. Co., Ltd. Method of preparing clarithromycin of form II crystals
KR100367981B1 (ko) * 2000-11-23 2003-01-14 한미약품공업 주식회사 클라리스로마이신 결정형 2의 제조 방법 및 이 방법에사용되는 결정성 클라리스로마이신 메실레이트 삼수화물
US6605707B1 (en) 2000-03-23 2003-08-12 Abbott Laboratories Process for the preparation of 6-O-propargyl erythromycin derivatives
US6900296B2 (en) * 2000-05-15 2005-05-31 Ranbaxy Laboratories Limited Cost effective method for selective methylation of erythromycin A derivatives
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
EP1648418A4 (en) 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
CA2533292C (en) 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
JP2006528189A (ja) 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
AU2004264939A1 (en) 2003-08-11 2005-02-24 Middlebrook Pharmaceuticals, Inc. Robust pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
CA2535780A1 (en) 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
AU2004273830B2 (en) 2003-09-15 2011-03-24 Shionogi, Inc. Antibiotic product, use and formulation thereof
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US20060111560A1 (en) * 2004-11-01 2006-05-25 Glenmark Pharmaceuticals Limited Process for the preparation of crystalline form II of clarithromycin
WO2006064299A1 (en) * 2004-12-13 2006-06-22 Wockhardt Limited Industrial process of clarithromycin associated with controlled level of side products
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923784A (en) * 1973-09-10 1975-12-02 Hoffmann La Roche Erythromycin a derivatives
US4264765A (en) * 1980-02-20 1981-04-28 Abbott Laboratories Salts of erythromycin A esters
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS60120895A (ja) * 1983-12-02 1985-06-28 Taisho Pharmaceut Co Ltd ６−０−メチル−２′−０，ν−ビス（ベンジルオキシカルボニル）−ν−デメチルエリスロマイシンａの製法
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体

Also Published As

Publication number Publication date
DE3661420D1 (en) 1989-01-19
JPH0676432B2 (ja) 1994-09-28
KR860007281A (ko) 1986-10-10
US4670549A (en) 1987-06-02
AU574265B2 (en) 1988-06-30
SU1468426A3 (ru) 1989-03-23
DK121586A (da) 1986-09-19
FI80708C (fi) 1990-07-10
DK172583B1 (da) 1999-02-08
AU5411086A (en) 1986-09-25
ES8800689A1 (es) 1987-11-16
GEP19960319B (en) 1996-06-24
EP0195960B1 (en) 1988-12-14
KR920002142B1 (ko) 1992-03-12
ES553048A0 (es) 1987-11-16
PT82210A (en) 1986-04-01
DK121586D0 (da) 1986-03-17
EP0195960A1 (en) 1986-10-01
CA1234806A (en) 1988-04-05
FI861072A0 (fi) 1986-03-14
FI80708B (fi) 1990-03-30
PT82210B (pt) 1988-07-29
JPS62149695A (ja) 1987-07-03

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: TAISHO PHARMACEUTICAL CO., LTD.

MA Patent expired