ES8604596A1 - Un procedimiento para la preparacion de una macrolida - Google Patents

Un procedimiento para la preparacion de una macrolida

Info

Publication number
ES8604596A1
ES8604596A1 ES525544A ES525544A ES8604596A1 ES 8604596 A1 ES8604596 A1 ES 8604596A1 ES 525544 A ES525544 A ES 525544A ES 525544 A ES525544 A ES 525544A ES 8604596 A1 ES8604596 A1 ES 8604596A1
Authority
ES
Spain
Prior art keywords
macrolide derivatives
amino
amino macrolide
derivatives
tylosin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525544A
Other languages
English (en)
Other versions
ES525544A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES525544A0 publication Critical patent/ES525544A0/es
Publication of ES8604596A1 publication Critical patent/ES8604596A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Fodder In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE MACROLIDAS Y DE SUS SALES DE ADICION DE ACIDOS DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO O UN GRUPO PROTECTOR DE HIDROXILO; Y R, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE REDUCCION DE UN ALDEHIDO DE FORMULA (II), EN PRESENCIA DE UNA AMINA DE FORMULA RH, EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA AMINACION REDUCTIVA SE LLEVA A CABO CON CIANOBOROHIDRURO SODICO, EN UN DISOLVENTE POLAR INERTE, COMO UN ALCANOL DE 1 A 4 ATOMOS DE CARBONO, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 60JC. ESTOS COMPUESTOS TIENEN APLICACIONES COMO ANTIBIOTICOS Y COMO INTERMEDIOS PARA LA SINTESIS DE ANTIBIOTICO
ES525544A 1982-09-13 1983-09-12 Un procedimiento para la preparacion de una macrolida Expired ES8604596A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41724782A 1982-09-13 1982-09-13

Publications (2)

Publication Number Publication Date
ES525544A0 ES525544A0 (es) 1986-02-01
ES8604596A1 true ES8604596A1 (es) 1986-02-01

Family

ID=23653182

Family Applications (2)

Application Number Title Priority Date Filing Date
ES525544A Expired ES8604596A1 (es) 1982-09-13 1983-09-12 Un procedimiento para la preparacion de una macrolida
ES548472A Expired ES8607336A1 (es) 1982-09-13 1985-10-31 Un procedimiento para la preparacion de una macrolida

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES548472A Expired ES8607336A1 (es) 1982-09-13 1985-10-31 Un procedimiento para la preparacion de una macrolida

Country Status (34)

Country Link
EP (1) EP0103465B1 (es)
JP (1) JPS5973598A (es)
KR (1) KR850000961B1 (es)
AR (1) AR241595A1 (es)
AT (1) AT381707B (es)
AU (1) AU561147B2 (es)
BG (1) BG42675A3 (es)
CA (1) CA1243310A (es)
CS (1) CS259862B2 (es)
CY (1) CY1417A (es)
DD (1) DD210284A5 (es)
DE (1) DE3366097D1 (es)
DK (1) DK153555C (es)
EG (1) EG16287A (es)
ES (2) ES8604596A1 (es)
FI (1) FI73222C (es)
GB (1) GB2127017B (es)
GR (1) GR79067B (es)
HK (1) HK21888A (es)
HU (1) HU194271B (es)
IE (1) IE55916B1 (es)
IL (1) IL69666A (es)
LU (1) LU90240I2 (es)
MY (1) MY8700756A (es)
NL (1) NL950001I2 (es)
NZ (1) NZ205501A (es)
PH (1) PH23242A (es)
PL (2) PL142304B1 (es)
PT (1) PT77335B (es)
RO (1) RO89235A (es)
SG (1) SG99287G (es)
SU (1) SU1375135A3 (es)
UA (1) UA6045A1 (es)
ZA (1) ZA836741B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59181294A (ja) * 1983-03-30 1984-10-15 Satoshi Omura 抗生物質ｐｔｌ−４４８とその誘導体およびそれらの製造方法
US4921947A (en) * 1986-03-31 1990-05-01 Eli Lilly And Company Process for preparing macrolide derivatives
US4820694A (en) * 1986-09-29 1989-04-11 Eli Lilly And Company Modifications of 3-O-demethylmycinose in macrocin and lactenocin
EP0262903A3 (en) * 1986-09-29 1988-11-02 Eli Lilly And Company New acyl derivatives of 20-modified tylosin and desmycosin compounds
US5354708A (en) * 1992-06-04 1994-10-11 Taskar Nikhil R Method of nitrogen doping of II-VI semiconductor compounds during epitaxial growth using an amine
TW226373B (es) * 1992-07-15 1994-07-11 Pfizer
ES2076107B1 (es) * 1993-09-20 1996-04-01 Pfizer Derivados de antibioticos macrolidos de anillos de 16 miembros.
AU3121095A (en) * 1994-09-22 1996-04-09 Pfizer Inc. Antibiotic macrolides
EP0778283A3 (en) * 1995-12-05 1998-01-28 Pfizer Inc. Antibiotic macrolides
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
DK0948967T3 (da) * 1998-03-02 2005-02-14 Lilly Co Eli Behandling af virussygdom hos svin
EP2019112A1 (en) 2007-07-26 2009-01-28 Intervet International BV Macrolide solid-state forms
US8227429B2 (en) 2006-07-28 2012-07-24 Intervet International B.V. Macrolide synthesis process and solid-state forms
EP2231635B1 (en) * 2007-12-07 2014-03-19 Eisai R&D Management Co., Ltd. Intermediates and methods for making zearalenone macrolide analogs
JP6494600B2 (ja) * 2013-05-23 2019-04-03 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｇｍｂｈ タイロシン誘導体およびその調製方法
CN103880903B (zh) * 2014-03-21 2016-06-15 烟台万润药业有限公司 一种泰乐菌素类大环内酯及其衍生物的制备方法
CN117510561B (zh) * 2023-11-30 2024-04-02 中国农业科学院饲料研究所 一种泰乐菌素衍生物及其制备方法与应用
CN117304241B (zh) * 2023-11-30 2024-03-01 中国农业科学院饲料研究所 一种大环内酯类化合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32839B1 (en) * 1967-12-04 1973-12-28 Lilly Co Eli Urea-antibiotic adducts and process for preparing the same
US4279896A (en) * 1980-06-23 1981-07-21 Schering Corporation Novel 20-imino macrolide antibacterial agents
JPS58146595A (ja) * 1982-02-25 1983-09-01 Satoshi Omura マクロライド系抗生物質

Also Published As

Publication number Publication date
IE55916B1 (en) 1991-02-27
DK153555C (da) 1988-12-05
AT381707B (de) 1986-11-25
JPS5973598A (ja) 1984-04-25
IL69666A0 (en) 1983-12-30
JPH021840B2 (es) 1990-01-12
IE832131L (en) 1984-03-13
ES8607336A1 (es) 1986-06-01
CS259862B2 (en) 1988-11-15
CS665383A2 (en) 1988-04-15
KR840005734A (ko) 1984-11-15
EP0103465B1 (en) 1986-09-10
DK413783D0 (da) 1983-09-12
ZA836741B (en) 1984-04-25
FI833229A (fi) 1984-03-14
PH23242A (en) 1989-06-06
PT77335B (en) 1986-05-19
IL69666A (en) 1987-10-20
ES525544A0 (es) 1986-02-01
DK153555B (da) 1988-07-25
GB8324044D0 (en) 1983-10-12
GR79067B (es) 1984-10-02
SU1375135A3 (ru) 1988-02-15
MY8700756A (en) 1987-12-31
NZ205501A (en) 1985-09-13
BG42675A3 (en) 1988-01-15
AU1871083A (en) 1984-03-22
FI833229A0 (fi) 1983-09-09
DK413783A (da) 1984-03-14
PL142304B1 (en) 1987-10-31
PT77335A (en) 1983-10-01
DE3366097D1 (en) 1986-10-16
ATA320683A (de) 1986-04-15
DD210284A5 (de) 1984-06-06
GB2127017A (en) 1984-04-04
NL950001I1 (nl) 1995-02-16
PL250619A1 (en) 1985-07-30
LU90240I2 (fr) 1998-07-06
PL243718A1 (en) 1985-04-09
EG16287A (en) 1987-04-30
EP0103465A1 (en) 1984-03-21
HK21888A (en) 1988-03-31
FI73222C (fi) 1987-09-10
UA6045A1 (uk) 1994-12-29
GB2127017B (en) 1986-01-15
NL950001I2 (nl) 1997-05-01
ES548472A0 (es) 1986-06-01
FI73222B (fi) 1987-05-29
CA1243310A (en) 1988-10-18
AU561147B2 (en) 1987-04-30
CY1417A (en) 1988-04-22
KR850000961B1 (ko) 1985-07-02
HU194271B (en) 1988-01-28
PL142251B1 (en) 1987-10-31
HUT35272A (en) 1985-06-28
RO89235A (ro) 1986-03-15
AR241595A1 (es) 1992-09-30
SG99287G (en) 1988-09-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051119