KR830007832A - 항생물질 A-4696인자 B₁,B₂,B₃,C₁a,C₃및 E₁의 제조방법 - Google Patents
항생물질 A-4696인자 B₁,B₂,B₃,C₁a,C₃및 E₁의 제조방법 Download PDFInfo
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- 230000003115 biocidal effect Effects 0.000 title claims description 12
- 238000000862 absorption spectrum Methods 0.000 claims description 13
- 102000003712 Complement factor B Human genes 0.000 claims description 5
- 108090000056 Complement factor B Proteins 0.000 claims description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 12
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical class N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 6
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 claims 6
- 239000000460 chlorine Substances 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000002798 polar solvent Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 241000187843 Actinoplanes missouriensis Species 0.000 claims 4
- 238000010521 absorption reaction Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002178 crystalline material Substances 0.000 claims 3
- 238000000926 separation method Methods 0.000 claims 3
- 231100000331 toxic Toxicity 0.000 claims 3
- 230000002588 toxic effect Effects 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 150000002170 ethers Chemical class 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 241000187844 Actinoplanes Species 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 238000010564 aerobic fermentation Methods 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
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Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
도면1는 KBr중 항생물질 A-4696인자 B1하이드로 클로라이드의 적외부 흡수 스펙트럼을 나타내며,
도면2는 KBr중 항생물질 A-4696인자 B2하이드로클로라이드의 적외부 흡수 스펙트럼을 나타내며,
도면3는 KBr중 항생물질 A-4696인자 B3하이드로 클로라이드의 적외부 흡수 스펙트럼을 나타내며,
도면4는 KBr중 항생물질 A-4696인자 C1a하이드로 클로라이드의 적외부 흡수 스펙트럼을 나타내며,
도면5는 KBr중 항생물질 A-4696인자 C3하이드로 클로라이드의 적외부 흡수 스펙트럼을 나타내며,
도면6는 KBr중 항생물질 A-4696인자 E1하이드로 클로라이드의 적외부 흡수 스펙트럼을 나타낸다.
Claims (8)
- 악티노플라네스 미주리엔시스(Actiono planesmissouriensis) 균주 ATCC 31680 ATCC 31682 또는 ATCC 31683 을 동화할 수 있는 탄수화물원, 질소원, 및 무기염류원을 함유하는 배양 배지 중에서 신부 호기성 발효 조건하 상당량의 항생활성이 생성될 때까지 배양시켜서 항생물질 A-4696 복합체를 제조하는 방법.
- 상기1항에 있어서, 배양배지로부터 A-4696 복합체를 분리하는 추가의 단계를 포함하는 방법.
- 상기1항 또는 2항에 있어서, 하이드로클로라이드염의 형태일때 물과 하이드록실 및 극성용매에 가용성이며 에테르, 클로로포름, 벤젠, 아세톤, 지방족 탄화수소류, 및 염소화 탄화수소류 등에 불용성인 백색 결정성 물질이며, 51.5%의 탄소, 5.25%의 수소, 4.88%의 질소, 4.62%의 염소 및 나머지의 산소의 대략적 조성을 가지며, 대략적 이론적 분자량이 1954이고, 물중 280nm에서 42.8의인 자외부 흡수 최대치를 가지며, KBr중 적외부흡수 스펙트럼에서 다음과 같은 구별할 수 있는 밴드(3380브로드, 2930, 1731, 1693, 1654, 1637, 1615, 1588, 1577, 1521, 1503, 1488, 1423, 1321, 1289, 1229, 1210, 1178, 1154, 1121, 1076, 1060, 1030, 1012, 982, 880, 842, 831및 810cm-1)를 가지는 항생물질 A-4696인자 B1또는 그의 약제학적으로 무독한 산부가염을 악티노플라네스 미주리엔시스 ATCC 31682 또는 ATCC 31683에 의해 생성되는 A-4696복합체로부터 분리시키는 방법.
- 상기1항 또는 2항에 있어서, 하이드로클로라이드 염의 형태일때, 물과 하이드록실 및 극성 용매에 가용성이며 에테르, 클로로포름, 벤젠, 아세톤, 지방족 탄화수소류 및 염소화 탄화수소류에 불용성인 백색 결정성 물질이며, 51.96%의 탄소, 4.67%의 수소 5.72%의 질소, 5.88%의 염소 및 나머지의 산소의 대략적 조성을 가지며, 대략적 이론 분자량이 1808이고, 물중 280nm에서 44.7의자외부 흡수 최대치를 가지며, KBr중 측정시 적외부 흡수 스펙트럼에서 다음과 같은 구별할 수 있는 밴드(3409 브로드, 2934, 1730, 1658, 1614, 1588, 1548, 1504, 1498, 1490, 1426, 1290, 1231, 1210, 1179, 1121, 1061, 1031, 1017, 987, 903, 884 및 818cm-1)를 가지는 항생물질 A-4696인자 B2또는 그의 약학적으로 무독한 산부가염을 악티노플라네스 미주리엔시스 ATCC 31680 또는 ATCC 31683에 의해 생성되는 A-4696복합체로 부터 분리시는 방법.
- 상기1 또는 제2항에 있어서, 하이드로클로라이드 염의 형태일때 물과 하이드록실 및 극성용매에 가용성이며 에테르, 클로로포름, 벤젠, 아세톤, 지방족 탄화수소류 및 염소화 탄화수소류에 불용성인 백색 결정성 물질이며, 51.84%의 탄소, 4.74%의 수소, 5.83%의 질소, 5.57%의 염소 및 나머지의 산소의 대략적 조성을 가지며, 대략적 이론적 분자량이 1808이고, 물중 280nm에서 46.3의자외부 흡수최대치를 가지며, KBr중 측정시 적외부 흡수스펙트럼에서 다음과 같은 구별할 수 있는 밴드(3394 브로드, 2938, 1733, 1697, 1675, 1656, 1638, 1614, 1591, 1515, 1504, 1489, 1427, 1359, 1291, 1228, 1209, 1180, 1120, 1072, 1051, 1018, 985, 903, 882, 846 및 816cm-1)를 가지는 항생물질 A-4696인자 B3또는 그의 약제학적으로 무독한 산부가염을 악티노플라네스 미주리엔시스 ATCC 31683에 의해 생성되는 A-4696복합체로 부터 분리시키는 방법.
- 상기1항 또는 2항에 있어서, 하이드로클로라이드염의 형태일때 물과 하이드록실 및 극성 용매에 가용성이며, 에테르, 클로로포름, 벤젠, 아세톤, 지방족 탄화수소류 및 염소화 탄화수소류에는 불용성인 백색 결정성 물질이며, 53.05%의 탄소, 4.74%의 수소, 5.83%의 질소, 5.39%의 염소 및 나머지의 산소의 대략적 조성을 가지며, 대략적 이론 분자량이 1792이며, 물중 279nm에서 47.9의자외부 흡수 최대치를 가지며, KBr중에서 결정된 적외부 흡수 스펙트럼에서 다음과 같은 구별할 수 있는 밴드(3380브로드, 2931, 1734, 1650, 1616, 1591, 1505, 1491, 1427, 1359, 1290, 1228, 1213, 1177, 1123, 1072, 1061, 1032, 1071, 987, 903, 832, 814, 및 715cm-1)를 가지는 항생물질 A-4696인자 C1a또는 그의 약제적으로 무독한 산부가염을 악티노플라네스 미주리엔시스 ATCC 31682 또는 ATCC 31683에 의해 생성되는 A-4696복합체로 부터 분리시키는 방법.
- 상기1항 또는 2항에 있어서, 하이드로클로라이드 염 형태일때, 물과 하이드록실 및 극성용매에 가용성이며, 에테르, 클로로포름, 벤젠, 아세톤, 지방족 탄화수소류 및 염소화 탄화수소류에는 불용성인 백색 결정성물질이며, 51.73%의 탄소, 4.69%의 수소, 5.94%의 질소, 6.02%의 염소 및 나머지의 산소의 대략적 조성을 가지며 물중 280nm에서 47.9의자외부 흡수 최대치를 가지며, KBr중에서 측정된 적외부 흡수 스펙트럼에서 다음과같은 구별할 수 있는 밴드(3378 브로드, 2925, 1728, 1658, 1637, 1616, 1589, 1579, 1573, 1546, 1536, 1529, 1523, 1503, 1489, 1474, 1457, 1426, 1421, 1397, 1387, 1286, 1231, 1206, 1121, 1075, 1062, 1028, 1012, 987, 965, 949, 878, 840, 816, 769, 708cm-1)를 가지는 항생물질 A-4696인자 C3또는 그의 약제학적으로 무독한 산부가염을 악티노플라네스 미주리엔시스 ATCC 31680 또는 ATCC 31683에 의해 생성되는 A-4696복합체로 부터 분리시키는 방법.
- 상기1항 또는 2항에 있어서, 하이드로클로 라이드염 형태일때, 물과 하이드록실 및 극성용매에 가용성이며, 에테르, 클로로포름, 벤젠, 아세톤, 지방족 탄화수소류 및 염소화 탄화수소류에 불용성인 백색 결정성물질이며, 50.71%의 탄소, 4.70%의 수소 9.01%의 질소, 1.84%의 염소 및 나머지의 산소의 대략적 조성을 가지며, 물중 279nm에서 39.9의자외부 흡수 스펙트럼을 가지며 KBr중 측정된 적외부 흡수 스펙트럼에서 다음과같은 구별할 수 있는 밴드(3394 브로드, 2933, 1657, 1636, 1610, 1589, 1538, 1511, 1505, 1453, 1424, 1393, 1369, 1328, 1320, 1291, 1232, 1212, 1178, 1120, 1075, 1061, 1031, 1018, 986, 973, 904, 878, 847, 813, 770, 752, 738 및 714cm-1)를 가지는 항생물질 A-4696인자 E1또는 그의 약학적으로 무독한 산부가염을 악티노플라네스 미주리엔시스 ATCC 31683 에 의해 생성되는 A-4696복합체로 부터 분리시키는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/217,962 US4322406A (en) | 1980-12-18 | 1980-12-18 | Antibiotic A-4696 factors B1, B2, B3, C1a, C3 and E1 |
| US217962 | 1980-12-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830007832A true KR830007832A (ko) | 1983-11-07 |
| KR850001503B1 KR850001503B1 (ko) | 1985-10-11 |
Family
ID=22813191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810004987A KR850001503B1 (ko) | 1980-12-18 | 1981-12-18 | 항생물질 A-4696인자B_1,B_2,B_3,C_1a,C_3 및 E_1의 제조방법 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4322406A (ko) |
| EP (1) | EP0055070B1 (ko) |
| JP (1) | JPS57132888A (ko) |
| KR (1) | KR850001503B1 (ko) |
| AR (1) | AR228377A1 (ko) |
| AT (1) | ATE23192T1 (ko) |
| AU (1) | AU547906B2 (ko) |
| CA (1) | CA1171008A (ko) |
| CS (1) | CS228909B2 (ko) |
| DD (2) | DD204389A5 (ko) |
| DE (1) | DE3175527D1 (ko) |
| DK (1) | DK562281A (ko) |
| ES (1) | ES8304203A1 (ko) |
| FI (1) | FI813958L (ko) |
| GB (1) | GB2089814B (ko) |
| GR (1) | GR77286B (ko) |
| HU (1) | HU189548B (ko) |
| IE (1) | IE51883B1 (ko) |
| IL (1) | IL64485A (ko) |
| NZ (1) | NZ199197A (ko) |
| PH (1) | PH18801A (ko) |
| PL (1) | PL134197B1 (ko) |
| PT (1) | PT74137B (ko) |
| RO (1) | RO82520A (ko) |
| YU (1) | YU292881A (ko) |
| ZA (1) | ZA818632B (ko) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537770A (en) * | 1982-03-24 | 1985-08-27 | Eli Lilly And Company | A41030 antibiotics |
| RO86375B1 (ro) * | 1982-03-24 | 1985-04-01 | Eli Lilly And Company | Procedeu pentru prepararea antibioticului a 41030 |
| US4713331A (en) * | 1982-03-24 | 1987-12-15 | Eli Lilly And Company | Microbial production of A41030 antibiotics |
| US4559323A (en) * | 1982-03-24 | 1985-12-17 | Eli Lilly And Company | A41030 Antibiotics |
| US4604239A (en) * | 1982-03-24 | 1986-08-05 | Eli Lilly And Company | Antibiotics |
| US4524135A (en) * | 1982-05-21 | 1985-06-18 | Eli Lilly And Company | A-21978C cyclic peptides |
| IL68700A0 (en) * | 1982-05-21 | 1983-09-30 | Lilly Co Eli | Improvements relating to a-21978c cyclic peptide derivatives and their production |
| US4462942A (en) * | 1982-07-30 | 1984-07-31 | Eli Lilly And Company | A47934 Antibiotic and process for production thereof |
| US4558009A (en) * | 1982-12-20 | 1985-12-10 | Eli Lilly And Company | Process for producing antibiotic A-51568 by fermentation and microorganism |
| PT77810A (en) * | 1982-12-20 | 1984-01-01 | Lilly Co Eli | Process for preparing antibiotic a51568 factors a and b |
| US4479897A (en) * | 1983-04-27 | 1984-10-30 | Eli Lilly And Company | Actaplanin antibiotics |
| US4672036A (en) * | 1983-07-13 | 1987-06-09 | Smithkline Beckman Corporation | Pure cultures of Kibdelsporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 and mutants thereof |
| US4548974A (en) * | 1983-07-13 | 1985-10-22 | Smithkline Beckman Corporation | Antibiotics produced by Kibdelosporangium aridum shearer |
| US4587218A (en) * | 1983-10-21 | 1986-05-06 | Eli Lilly And Company | Novel bioconverting microorganisms |
| US4563442A (en) * | 1983-10-21 | 1986-01-07 | Eli Lilly And Company | Glycopeptide bioconversion products |
| US4504467A (en) * | 1983-10-21 | 1985-03-12 | Eli Lilly And Company | Glycopeptide derivatives |
| US4663282A (en) * | 1983-10-21 | 1987-05-05 | Eli Lilly And Company | Glycopeptide antibiotic CUC/CSV and process for its production |
| US4537715A (en) * | 1983-10-21 | 1985-08-27 | Eli Lilly And Company | Glycopeptide antibiotic CUC/CSV and process for its production |
| US4497802A (en) * | 1983-10-21 | 1985-02-05 | Eli Lilly And Company | N-Acyl glycopeptide derivatives |
| US4558008A (en) * | 1983-12-13 | 1985-12-10 | Eli Lilly And Company | Process for production of A-51568B antibiotic |
| AU579120B2 (en) * | 1983-12-16 | 1988-11-17 | Gruppo Lepetit S.P.A. | Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts |
| US4558036A (en) * | 1984-02-17 | 1985-12-10 | Eli Lilly And Company | Actaplanin antibiotics |
| US4859599A (en) * | 1984-10-11 | 1989-08-22 | The Dow Chemical Company | Antibiotic A26201-1 and antibiotic A26201-2 produced by a novel strain of actinoplanes |
| US4613503A (en) * | 1984-10-11 | 1986-09-23 | The Dow Chemical Company | Antibiotic A26201-1 and antibiotic A26201-2 produced by a novel strain of actinoplanes |
| GB8608798D0 (en) * | 1986-04-11 | 1986-05-14 | Lepetit Spa | Recovery of glycopeptide antibiotics from aqueous solutions |
| GB8624251D0 (en) * | 1986-10-09 | 1986-11-12 | Erba Farmitalia | "1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives |
| US4939244A (en) * | 1987-01-30 | 1990-07-03 | American Cyanamid Company | Pseudoaglycones of LL-E33288 antibiotics |
| US4845194A (en) * | 1987-02-27 | 1989-07-04 | Eli Lilly And Company | Glycopeptide recovery process |
| US5213797A (en) * | 1987-07-13 | 1993-05-25 | Eli Lilly And Company | A80407 antibiotics |
| US4996148A (en) * | 1987-07-13 | 1991-02-26 | Eli Lilly And Company | A80407 antibiotics |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3952095A (en) * | 1972-06-02 | 1976-04-20 | Eli Lilly And Company | Novel antibiotic and a process for the production thereof |
| US4064233A (en) * | 1974-12-17 | 1977-12-20 | Eli Lilly And Company | Antibiotic A-4696 |
| US4115552A (en) * | 1976-04-19 | 1978-09-19 | Eli Lilly And Company | Factor A and B of antibiotic A-4696 |
| GB1578480A (en) * | 1977-05-19 | 1980-11-05 | Lilly Co Eli | Antibiotic a-35512 and process for production thereof |
| GB2045231B (en) * | 1979-04-07 | 1983-08-03 | Lepetit Spa | Antibiotic a/16686 and its preparation from actinoplanes |
| CA1170598A (en) * | 1979-12-13 | 1984-07-10 | Bernard J. Abbott | Process for the preparation of cyclic peptide nuclei |
-
1980
- 1980-12-18 US US06/217,962 patent/US4322406A/en not_active Expired - Fee Related
-
1981
- 1981-12-08 NZ NZ199197A patent/NZ199197A/en unknown
- 1981-12-08 IL IL64485A patent/IL64485A/xx unknown
- 1981-12-08 PH PH26593A patent/PH18801A/en unknown
- 1981-12-09 CA CA000391804A patent/CA1171008A/en not_active Expired
- 1981-12-09 AR AR287741A patent/AR228377A1/es active
- 1981-12-09 FI FI813958A patent/FI813958L/fi not_active Application Discontinuation
- 1981-12-10 GR GR66772A patent/GR77286B/el unknown
- 1981-12-11 ZA ZA818632A patent/ZA818632B/xx unknown
- 1981-12-14 YU YU02928/81A patent/YU292881A/xx unknown
- 1981-12-15 RO RO81106003A patent/RO82520A/ro unknown
- 1981-12-16 EP EP81305898A patent/EP0055070B1/en not_active Expired
- 1981-12-16 DE DE8181305898T patent/DE3175527D1/de not_active Expired
- 1981-12-16 AT AT81305898T patent/ATE23192T1/de active
- 1981-12-16 GB GB8137913A patent/GB2089814B/en not_active Expired
- 1981-12-16 PT PT74137A patent/PT74137B/pt unknown
- 1981-12-17 AU AU78598/81A patent/AU547906B2/en not_active Ceased
- 1981-12-17 ES ES508085A patent/ES8304203A1/es not_active Expired
- 1981-12-17 CS CS819462A patent/CS228909B2/cs unknown
- 1981-12-17 DK DK562281A patent/DK562281A/da not_active Application Discontinuation
- 1981-12-17 IE IE2971/81A patent/IE51883B1/en unknown
- 1981-12-17 JP JP56206004A patent/JPS57132888A/ja active Pending
- 1981-12-17 HU HU813813A patent/HU189548B/hu unknown
- 1981-12-18 KR KR1019810004987A patent/KR850001503B1/ko active
- 1981-12-18 DD DD81244038A patent/DD204389A5/de unknown
- 1981-12-18 PL PL1981234311A patent/PL134197B1/pl unknown
- 1981-12-18 DD DD81235954A patent/DD202048A5/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL234311A1 (ko) | 1982-08-16 |
| GB2089814B (en) | 1984-05-16 |
| DD202048A5 (de) | 1983-08-24 |
| CS228909B2 (en) | 1984-05-14 |
| IE812971L (en) | 1982-06-18 |
| IL64485A (en) | 1985-01-31 |
| AU7859881A (en) | 1982-06-24 |
| KR850001503B1 (ko) | 1985-10-11 |
| HU189548B (en) | 1986-07-28 |
| GB2089814A (en) | 1982-06-30 |
| RO82520A (ro) | 1983-09-26 |
| ES508085A0 (es) | 1983-02-16 |
| EP0055070B1 (en) | 1986-10-29 |
| PT74137A (en) | 1982-01-01 |
| IL64485A0 (en) | 1982-03-31 |
| ATE23192T1 (de) | 1986-11-15 |
| DK562281A (da) | 1982-06-19 |
| NZ199197A (en) | 1984-11-09 |
| YU292881A (en) | 1983-10-31 |
| GR77286B (ko) | 1984-09-11 |
| PL134197B1 (en) | 1985-07-31 |
| US4322406A (en) | 1982-03-30 |
| ES8304203A1 (es) | 1983-02-16 |
| AU547906B2 (en) | 1985-11-14 |
| JPS57132888A (en) | 1982-08-17 |
| PH18801A (en) | 1985-09-27 |
| AR228377A1 (es) | 1983-02-28 |
| DD204389A5 (de) | 1983-11-30 |
| PT74137B (en) | 1984-05-09 |
| ZA818632B (en) | 1982-10-27 |
| IE51883B1 (en) | 1987-04-15 |
| CA1171008A (en) | 1984-07-17 |
| DE3175527D1 (en) | 1986-12-04 |
| EP0055070A1 (en) | 1982-06-30 |
| FI813958L (fi) | 1982-06-19 |
| RO82520B (ro) | 1983-08-30 |
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