JPS56139499A - Novel antibiotic substance, mucopeptin a and c, and their preparation - Google Patents

Novel antibiotic substance, mucopeptin a and c, and their preparation

Info

Publication number
JPS56139499A
JPS56139499A JP4258480A JP4258480A JPS56139499A JP S56139499 A JPS56139499 A JP S56139499A JP 4258480 A JP4258480 A JP 4258480A JP 4258480 A JP4258480 A JP 4258480A JP S56139499 A JPS56139499 A JP S56139499A
Authority
JP
Japan
Prior art keywords
substances
mucopeptin
decomposition
methanol
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4258480A
Other languages
Japanese (ja)
Other versions
JPS5740160B2 (en
Inventor
Kiyoshi Isono
Taketo Nakamura
Hiroo Kusakabe
Tomonobu Kusano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIKEN Institute of Physical and Chemical Research
Original Assignee
RIKEN Institute of Physical and Chemical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RIKEN Institute of Physical and Chemical Research filed Critical RIKEN Institute of Physical and Chemical Research
Priority to JP4258480A priority Critical patent/JPS56139499A/en
Publication of JPS56139499A publication Critical patent/JPS56139499A/en
Publication of JPS5740160B2 publication Critical patent/JPS5740160B2/ja
Granted legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

NEW MATERIAL:Antibiotic substances, mucopeptin A and C, having the following physico-chemical and biological properties: Elemental analysis, (A) C 51.97%, H 6.19%, N 10.04%, S 2.34%, (C) C 51.27%, H 5.88%, N 11.86%, S 3.37%; molecular weight (titration method), (A) 1,120, (C) 800; melting point (A) 172W 180°C (decomposition ), (C) 178W182°C (decomposition); specific rotation, (A) [α]D20=-25.4°, (C)[α]D20=-39.7° (C=1.00, 50% methanol in both cases); solubility, both substances are soluble in water, methanol, etc., and hardly soluble in acetone, benzene, etc.; antibacterial spectrum, both substances have growth inhibtion activity to Gram-negative bacteria and acid-fast bacteria.
USE: Antibacterial agent against Gram-negative bacteria and acid-fast bacteria.
PROCESS: Streptomyces sp. K-64 strain (FREM-P No.5387) is cultured at 25W 35°C pref. under nearly neutral conditions, and the produced micopeptin A, C complex is separated into each constituent by chromatography, etc.
COPYRIGHT: (C)1981,JPO&Japio
JP4258480A 1980-04-01 1980-04-01 Novel antibiotic substance, mucopeptin a and c, and their preparation Granted JPS56139499A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4258480A JPS56139499A (en) 1980-04-01 1980-04-01 Novel antibiotic substance, mucopeptin a and c, and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4258480A JPS56139499A (en) 1980-04-01 1980-04-01 Novel antibiotic substance, mucopeptin a and c, and their preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP57038893A Division JPS583676B2 (en) 1982-03-12 1982-03-12 Novel antibiotic mucopeptin C and its production method

Publications (2)

Publication Number Publication Date
JPS56139499A true JPS56139499A (en) 1981-10-30
JPS5740160B2 JPS5740160B2 (en) 1982-08-25

Family

ID=12640110

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4258480A Granted JPS56139499A (en) 1980-04-01 1980-04-01 Novel antibiotic substance, mucopeptin a and c, and their preparation

Country Status (1)

Country Link
JP (1) JPS56139499A (en)

Also Published As

Publication number Publication date
JPS5740160B2 (en) 1982-08-25

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