KR940011630A - 구충제 화합물 제조용의 스트렙토마이세스 균주 및 이의 사용방법 - Google Patents

구충제 화합물 제조용의 스트렙토마이세스 균주 및 이의 사용방법 Download PDF

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KR940011630A
KR940011630A KR1019930025314A KR930025314A KR940011630A KR 940011630 A KR940011630 A KR 940011630A KR 1019930025314 A KR1019930025314 A KR 1019930025314A KR 930025314 A KR930025314 A KR 930025314A KR 940011630 A KR940011630 A KR 940011630A
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avermectin
preparation
methods
same
compounds
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KR1019930025314A
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본조우클리안 로잔느
쥬니어 오티스 웹스터 가드프레이
앨렌 스미트카 팀
체-퐁 야오 레이몬드
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리로이 휘테커
일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

본 발명은 신규한 미생물 스트렙토마이세스 아베르미틸리스아종 나이제르(Streptomyces avermitilis subpecies niger) NRRL 21005, 상기 미생물을 사용한 공지된 아베르멕틴 및 이베르멕틴의 제조방법에 관한 것이다.

Description

구충제 화합물의 제조용의 스트렙토마이세스 균주 및 이의 사용방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 스트렙토마이세스 아베르미틸리스 아종 나이제르(Streptomyces avermitilis subpecies niger) NRRL 21005(A58267.2) 및 다른 스트렙토마이세스 아베르 미틸리스 종의 덴드로그람(dendrogram)을 나타낸다.
제2도는 A58267.2와 스트렙토마이세스 아베르미틸리스 종 사이의 관계를 나타내는 지방산 분석값으로부터의 주성분을 플롯을 나타낸다.

Claims (3)

  1. 미생물스트렙토마이세스 아베르미틸리스 아종 나이제르(Streptomyces avermitilis subpecies niger) NRRL 21005의 생물학적으로 순수한 배양체, 또는 그의 아베르멕틴(avermectin)-생산 돌연변이체 또는 변형체.
  2. 스트렙토마이세스 아베르미틸리스 아종 나이제르 NRRL 21005, 또는 그의 아베르멕틴-생성 돌연변이체 또는 변형체를 적어도 하나의 아베르멕틴 화합물이 생성될 때까지 심부 통기 배양 조건하에 탄소, 질소 및 무기염의 동화성(assimilable) 공급원을 함유한 수성 배지중에서 배양함을 포함하는, 적어도 하나의 아베르멕틴 화학물을 제조하는 방법.
  3. 스트렙토마이세스 아베르미틸리스 아종 나이제르 NRRL 21005, 또는 그의 아베르멕틴-생산 돌연변이체 또는 변형체를 아베르멕틴 화합물 B1a 및 B1b가 생성될 때까지 심부 통기 배양 조건하에 탄소, 질소 및 무기염의 동화성 공급원을 함유한 수성 배지중에서 배양하고, 생성된 B1a 및 B1b 화합물을 환원시킴을 포함하는, 이베르멕틴(ivermectin)의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930025314A 1992-11-30 1993-11-26 구충제 화합물 제조용의 스트렙토마이세스 균주 및 이의 사용방법 KR940011630A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/984,078 US5292647A (en) 1992-11-30 1992-11-30 Strain of streptomyces for producing avermectins and processes therewith
US984,078 1992-11-30

Publications (1)

Publication Number Publication Date
KR940011630A true KR940011630A (ko) 1994-06-21

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KR1019930025314A KR940011630A (ko) 1992-11-30 1993-11-26 구충제 화합물 제조용의 스트렙토마이세스 균주 및 이의 사용방법

Country Status (21)

Country Link
US (1) US5292647A (ko)
EP (1) EP0600656A3 (ko)
JP (1) JPH06237761A (ko)
KR (1) KR940011630A (ko)
CN (1) CN1088983A (ko)
AU (1) AU667141B2 (ko)
BR (1) BR9304843A (ko)
CA (1) CA2109767A1 (ko)
CO (1) CO4130314A1 (ko)
CZ (1) CZ282908B6 (ko)
FI (1) FI935246A (ko)
HU (1) HUT69970A (ko)
IL (1) IL107702A (ko)
MX (1) MX9307410A (ko)
MY (1) MY109797A (ko)
NO (1) NO934293L (ko)
NZ (1) NZ250247A (ko)
PH (1) PH30116A (ko)
PL (1) PL301204A1 (ko)
RU (1) RU2125609C1 (ko)
ZA (1) ZA938723B (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100419554B1 (ko) * 1999-10-29 2004-02-19 주식회사유한양행 아버멕틴의 정제방법
KR20190031865A (ko) * 2017-09-18 2019-03-27 주식회사 팜한농 밀베마이신 d를 생산하는 재조합 미생물 및 밀베마이신 d 생산 방법

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1902537B (zh) * 2004-01-08 2010-12-08 夏普株式会社 显示装置用照明装置和液晶显示装置
CN100448984C (zh) * 2006-03-07 2009-01-07 广东省微生物研究所 粤蓝链霉菌
CN102016054A (zh) * 2008-04-25 2011-04-13 株式会社太平洋 用生物转化系统制备正二羟基异黄酮的方法
CN102443555B (zh) * 2011-11-16 2013-04-24 南开大学 链霉菌Streptomyces sp.NK-660及其用于生产ε-聚赖氨酸的发酵培养方法
WO2017052232A1 (ko) * 2015-09-22 2017-03-30 주식회사 팜한농 밀베마이신을 생산하는 재조합 미생물 및 이를 이용한 밀베마이신 생산
CN114075527B (zh) * 2021-10-25 2024-03-26 成都大学 一种脂溶性抗生素生物发酵调控的方法

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SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
IN167980B (ko) * 1987-01-23 1991-01-19 Pfizer
EP0284176B1 (en) * 1987-01-23 1993-08-25 Pfizer Inc. Process for production of avermectins and cultures therefor
US5015662A (en) * 1988-10-18 1991-05-14 Merck & Co., Inc. Anthelmintic bioconversion products
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100419554B1 (ko) * 1999-10-29 2004-02-19 주식회사유한양행 아버멕틴의 정제방법
KR20190031865A (ko) * 2017-09-18 2019-03-27 주식회사 팜한농 밀베마이신 d를 생산하는 재조합 미생물 및 밀베마이신 d 생산 방법

Also Published As

Publication number Publication date
PH30116A (en) 1996-12-27
EP0600656A2 (en) 1994-06-08
CA2109767A1 (en) 1994-05-31
IL107702A (en) 1998-10-30
NZ250247A (en) 1994-12-22
CZ250293A3 (en) 1994-06-15
MY109797A (en) 1997-07-31
JPH06237761A (ja) 1994-08-30
HU9303366D0 (en) 1994-03-28
NO934293D0 (no) 1993-11-26
HUT69970A (en) 1995-09-28
AU5196093A (en) 1994-06-09
PL301204A1 (en) 1994-06-13
IL107702A0 (en) 1994-02-27
FI935246A0 (fi) 1993-11-25
MX9307410A (es) 1994-07-29
ZA938723B (en) 1995-05-22
NO934293L (no) 1994-05-31
AU667141B2 (en) 1996-03-07
BR9304843A (pt) 1994-06-14
CO4130314A1 (es) 1995-02-13
CZ282908B6 (cs) 1997-11-12
CN1088983A (zh) 1994-07-06
FI935246A (fi) 1994-05-31
US5292647A (en) 1994-03-08
RU2125609C1 (ru) 1999-01-27
EP0600656A3 (en) 1995-07-05

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