JPS55118396A - Preparation of mitomycin derivative - Google Patents

Preparation of mitomycin derivative

Info

Publication number
JPS55118396A
JPS55118396A JP2341279A JP2341279A JPS55118396A JP S55118396 A JPS55118396 A JP S55118396A JP 2341279 A JP2341279 A JP 2341279A JP 2341279 A JP2341279 A JP 2341279A JP S55118396 A JPS55118396 A JP S55118396A
Authority
JP
Japan
Prior art keywords
cultivation
medium
culture
streptomyces
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2341279A
Other languages
Japanese (ja)
Inventor
Chikahiro Urakawa
Masaji Kasai
Atsuko Iwasaki
Kimikatsu Shirahata
Kinichi Nakano
Shu Takahashi
Kazuyuki Mineura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2341279A priority Critical patent/JPS55118396A/en
Publication of JPS55118396A publication Critical patent/JPS55118396A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare a mitomycin derivative useful as germicides, detergents, or drugs, having a wide range of antimicrobial activity, by culturing a microorganism capable of producing a specific compound, belonging to the genus of Streptomyces in a nutrient medium.
CONSTITUTION: A microorganism (e.g. Streptomyces casspitosus ATCC27422) capable of producing the above-mentioned compound shown by the formula is cultured by a conventional cultivation of actinomycetes. Namely, a medium having a carbon and nitrogen sources, inorganic matters, and, if necessary, a proper amount of other nutrient source is used as a medium for culture. The culture is done by shaking cultivation or by aerating cultivation in deep part with stirring under aerobic conditions. The culture is carried out usually at 25W35°C and the pH of the medium in cultivation is about 6W8. The desired compound can be prepared from the culture solution having finished its cultivation by a conventional method used for the purification of antibiotics. For example, 10-dicarbamoyloxy- dihydromitomycin B can be cited as the compound shown by the formula.
COPYRIGHT: (C)1980,JPO&Japio
JP2341279A 1979-03-02 1979-03-02 Preparation of mitomycin derivative Pending JPS55118396A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2341279A JPS55118396A (en) 1979-03-02 1979-03-02 Preparation of mitomycin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2341279A JPS55118396A (en) 1979-03-02 1979-03-02 Preparation of mitomycin derivative

Publications (1)

Publication Number Publication Date
JPS55118396A true JPS55118396A (en) 1980-09-11

Family

ID=12109772

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2341279A Pending JPS55118396A (en) 1979-03-02 1979-03-02 Preparation of mitomycin derivative

Country Status (1)

Country Link
JP (1) JPS55118396A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853385A (en) * 1987-03-31 1989-08-01 Kyowa Hakko Kogyo Co., Ltd. 7-N,8-N-Ethylenemitomycin 8-imines
US4880825A (en) * 1987-03-25 1989-11-14 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
US5021423A (en) * 1988-05-30 1991-06-04 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives and intermediates therefor

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880825A (en) * 1987-03-25 1989-11-14 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
EP0284380B1 (en) * 1987-03-25 1992-06-10 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
US4853385A (en) * 1987-03-31 1989-08-01 Kyowa Hakko Kogyo Co., Ltd. 7-N,8-N-Ethylenemitomycin 8-imines
US5021423A (en) * 1988-05-30 1991-06-04 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives and intermediates therefor

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