JPS5473195A - Preparation of tomaymycins - Google Patents

Preparation of tomaymycins

Info

Publication number
JPS5473195A
JPS5473195A JP14025377A JP14025377A JPS5473195A JP S5473195 A JPS5473195 A JP S5473195A JP 14025377 A JP14025377 A JP 14025377A JP 14025377 A JP14025377 A JP 14025377A JP S5473195 A JPS5473195 A JP S5473195A
Authority
JP
Japan
Prior art keywords
culturing
tomaymycins
activity
nocardia
microbials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14025377A
Other languages
Japanese (ja)
Other versions
JPS615396B2 (en
Inventor
Eiji Higashide
Seiichi Tanida
Yoshi Haibara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP14025377A priority Critical patent/JPS5473195A/en
Publication of JPS5473195A publication Critical patent/JPS5473195A/en
Publication of JPS615396B2 publication Critical patent/JPS615396B2/ja
Granted legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare tomaymycins having antibacterial activity, antiphagic activity, and activity to inhibit the growth of mouse leukemia cell L-121, and useful as a disinfectant, by culturing microbials belonging to Nocardia genus.
CONSTITUTION: Antibiotic substance tomaymycine of formula (R is H, 1W5C alkyl) having a benzodiazepin structure, is prepared by culturing microbials belonging to Nocardia genus and capable of producing tomaymycins, e.g. Nocardia sp. No. C-15003 (FERM-P No.3992) usually at 20W35°C. The temperature in the middle stage of cultivation is pref. 23W30°C, and pH at the beginning of the cultivation is pref. 6.5W7.5. The period of culturing is 2W8 days in case of aerated and agitated culturing.
COPYRIGHT: (C)1979,JPO&Japio
JP14025377A 1977-11-22 1977-11-22 Preparation of tomaymycins Granted JPS5473195A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14025377A JPS5473195A (en) 1977-11-22 1977-11-22 Preparation of tomaymycins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14025377A JPS5473195A (en) 1977-11-22 1977-11-22 Preparation of tomaymycins

Publications (2)

Publication Number Publication Date
JPS5473195A true JPS5473195A (en) 1979-06-12
JPS615396B2 JPS615396B2 (en) 1986-02-18

Family

ID=15264469

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14025377A Granted JPS5473195A (en) 1977-11-22 1977-11-22 Preparation of tomaymycins

Country Status (1)

Country Link
JP (1) JPS5473195A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU764786B2 (en) * 1998-11-17 2003-08-28 Sanofi-Aventis Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU764786B2 (en) * 1998-11-17 2003-08-28 Sanofi-Aventis Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress
US6767533B1 (en) * 1998-11-17 2004-07-27 Sanofi-Synthelabo Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress

Also Published As

Publication number Publication date
JPS615396B2 (en) 1986-02-18

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