JPS5473195A - Preparation of tomaymycins - Google Patents
Preparation of tomaymycinsInfo
- Publication number
- JPS5473195A JPS5473195A JP14025377A JP14025377A JPS5473195A JP S5473195 A JPS5473195 A JP S5473195A JP 14025377 A JP14025377 A JP 14025377A JP 14025377 A JP14025377 A JP 14025377A JP S5473195 A JPS5473195 A JP S5473195A
- Authority
- JP
- Japan
- Prior art keywords
- culturing
- tomaymycins
- activity
- nocardia
- microbials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare tomaymycins having antibacterial activity, antiphagic activity, and activity to inhibit the growth of mouse leukemia cell L-121, and useful as a disinfectant, by culturing microbials belonging to Nocardia genus.
CONSTITUTION: Antibiotic substance tomaymycine of formula (R is H, 1W5C alkyl) having a benzodiazepin structure, is prepared by culturing microbials belonging to Nocardia genus and capable of producing tomaymycins, e.g. Nocardia sp. No. C-15003 (FERM-P No.3992) usually at 20W35°C. The temperature in the middle stage of cultivation is pref. 23W30°C, and pH at the beginning of the cultivation is pref. 6.5W7.5. The period of culturing is 2W8 days in case of aerated and agitated culturing.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14025377A JPS5473195A (en) | 1977-11-22 | 1977-11-22 | Preparation of tomaymycins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14025377A JPS5473195A (en) | 1977-11-22 | 1977-11-22 | Preparation of tomaymycins |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5473195A true JPS5473195A (en) | 1979-06-12 |
JPS615396B2 JPS615396B2 (en) | 1986-02-18 |
Family
ID=15264469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14025377A Granted JPS5473195A (en) | 1977-11-22 | 1977-11-22 | Preparation of tomaymycins |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5473195A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU764786B2 (en) * | 1998-11-17 | 2003-08-28 | Sanofi-Aventis | Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress |
-
1977
- 1977-11-22 JP JP14025377A patent/JPS5473195A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU764786B2 (en) * | 1998-11-17 | 2003-08-28 | Sanofi-Aventis | Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress |
US6767533B1 (en) * | 1998-11-17 | 2004-07-27 | Sanofi-Synthelabo | Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress |
Also Published As
Publication number | Publication date |
---|---|
JPS615396B2 (en) | 1986-02-18 |
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