FR2385798A1 - Procede de production de maytansinol et de ses derives par voie microbiologique - Google Patents

Procede de production de maytansinol et de ses derives par voie microbiologique

Info

Publication number
FR2385798A1
FR2385798A1 FR7730340A FR7730340A FR2385798A1 FR 2385798 A1 FR2385798 A1 FR 2385798A1 FR 7730340 A FR7730340 A FR 7730340A FR 7730340 A FR7730340 A FR 7730340A FR 2385798 A1 FR2385798 A1 FR 2385798A1
Authority
FR
France
Prior art keywords
maytansinol
derivatives
production
propionate
maytanacine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7730340A
Other languages
English (en)
Other versions
FR2385798B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2385798A1 publication Critical patent/FR2385798A1/fr
Application granted granted Critical
Publication of FR2385798B1 publication Critical patent/FR2385798B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

La présente invention concerne un procédé de production de maytansinol et de ses dérivés. Le maytansinol, la maytanacine ou le propionate de maytansinol sont produits par culture d'un microorganisme appartenant au genre Nocardia capable de produire du maytansinol, de la maytanacine ou du propionate de maytansinol dans un milieu de culture contenant des sources de carbone assimilables et des sources digestibles jusqu'à ce que le maytansinol, la maytanacine ou le propionate de maytansinol soient accumulés de façon substantielle dans ce milieu et récupération de ces composés. Les composés obtenus selon l'invention sont utiles comme agents antimitotiques.
FR7730340A 1977-03-31 1977-10-07 Procede de production de maytansinol et de ses derives par voie microbiologique Granted FR2385798A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52037167A JPS6010718B2 (ja) 1977-03-31 1977-03-31 メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法

Publications (2)

Publication Number Publication Date
FR2385798A1 true FR2385798A1 (fr) 1978-10-27
FR2385798B1 FR2385798B1 (fr) 1980-04-25

Family

ID=12490032

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7730340A Granted FR2385798A1 (fr) 1977-03-31 1977-10-07 Procede de production de maytansinol et de ses derives par voie microbiologique

Country Status (20)

Country Link
JP (1) JPS6010718B2 (fr)
AT (1) AT362058B (fr)
AU (1) AU507869B2 (fr)
CA (1) CA1092999A (fr)
CH (1) CH631740A5 (fr)
CS (1) CS214881B2 (fr)
DE (1) DE2746253C2 (fr)
DK (1) DK143570C (fr)
ES (1) ES463206A1 (fr)
FR (1) FR2385798A1 (fr)
GB (1) GB1554395A (fr)
HU (1) HU177391B (fr)
IE (1) IE45888B1 (fr)
IT (1) IT1094003B (fr)
NL (1) NL7711273A (fr)
PL (1) PL108863B1 (fr)
PT (1) PT67853B (fr)
SE (1) SE7711543L (fr)
SU (1) SU938746A3 (fr)
YU (1) YU243777A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2409306A1 (fr) * 1977-11-18 1979-06-15 Takeda Chemical Industries Ltd Procede de production de l'antibiotique c-15003 p-4 par culture d'un micro-organisme du genre nocardia
FR2409307A1 (fr) * 1977-11-18 1979-06-15 Takeda Chemical Industries Ltd Procede de production de l'antibiotique c-15003 p-3 par culture d'un micro-organisme
EP0019934A1 (fr) * 1979-06-05 1980-12-10 Takeda Chemical Industries, Ltd. Antibiotiques C-15003 PND et procédé pour leur préparation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028683A1 (fr) * 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotique C-15003 PHO et sa préparation
US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US7432088B2 (en) 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
CN116239607B (zh) * 2023-01-04 2024-04-09 山东大学 一种美登素衍生物及其生物合成方法与应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV6013/75 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2409306A1 (fr) * 1977-11-18 1979-06-15 Takeda Chemical Industries Ltd Procede de production de l'antibiotique c-15003 p-4 par culture d'un micro-organisme du genre nocardia
FR2409307A1 (fr) * 1977-11-18 1979-06-15 Takeda Chemical Industries Ltd Procede de production de l'antibiotique c-15003 p-3 par culture d'un micro-organisme
EP0019934A1 (fr) * 1979-06-05 1980-12-10 Takeda Chemical Industries, Ltd. Antibiotiques C-15003 PND et procédé pour leur préparation

Also Published As

Publication number Publication date
DE2746253C2 (de) 1986-08-21
AU2907377A (en) 1979-03-29
FR2385798B1 (fr) 1980-04-25
JPS53121998A (en) 1978-10-24
DK143570C (da) 1982-02-08
SE7711543L (sv) 1978-10-01
CH631740A5 (en) 1982-08-31
IE45888B1 (en) 1982-12-29
PL108863B1 (en) 1980-05-31
HU177391B (en) 1981-09-28
GB1554395A (en) 1979-10-17
IT7821819A0 (it) 1978-03-30
DK458977A (da) 1978-10-01
DK143570B (da) 1981-09-07
CS214881B2 (en) 1982-06-25
NL7711273A (nl) 1978-10-03
PL201539A1 (pl) 1978-09-25
DE2746253A1 (de) 1978-10-05
YU243777A (en) 1982-06-30
IE45888L (en) 1978-09-30
PT67853A (en) 1978-04-01
IT1094003B (it) 1985-07-26
AU507869B2 (en) 1980-02-28
ES463206A1 (es) 1978-08-16
SU938746A3 (ru) 1982-06-23
ATA736377A (de) 1980-09-15
CA1092999A (fr) 1981-01-06
JPS6010718B2 (ja) 1985-03-19
PT67853B (en) 1980-05-05
AT362058B (de) 1981-04-27

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